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Elaboration of sponge-like particles for textile functionalization and skin penetration

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Abstract

The preparation and characterization of active-loaded microparticles for cosmetic textile applications were studied in this work. The double emulsion diffusion/evaporation technique was served and the Eudragit® RS100 (ethyl acrylate and methyl methacrylate copolymers) was used as biodegradable polymer. Two actives molecules, vitamin E and Lauryl isoquinolinium bromide (LIB) were successfully loaded during the formulation. Obtained particles were spherical in shape with a little variable diameter about 1 μm and zeta potential of 55 mV. The cutaneous penetration of the particles was evaluated by dermal microdialysis, tape stripping, and punch-biopsy techniques from ex vivo human skin. LIB or vitamin E concentrations in the different layers of the skin were analyzed by high-performance liquid chromatography method. Finally, these particles were adsorbed onto a textile in optimized conditions. The scanning electron microscopy is used to confirm the total threads coverage by particles.

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Acknowledgments

This work has been achieved in the frame of Texactiv research program and has been supported by French public agency, OSEO.

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Authors and Affiliations

  1. CNRS, UMR 5007, LAGEP-CPE, University Lyon1 Villeurbanne, 43 bd 11 Novembre 1918, F-69622, Villeurbanne, France

    Ahmad Bitar, Nadiah Zafar, Jean Pierre Valour, Géraldine Agusti, Hatem Fessi & Abdelhamid Elaissari

  2. Laboratory of Engineering and Cutaneous Biology, INSERM UMR 1098, Medicine and Pharmaceutical University, 19 rue Ambroise Paré, 25000, Besançon, France

    Philippe Humbert, Sophie Robin & Céline Viennet

  3. LETIAM, EA 4041, IUT d’Orsay, Université Paris Sud 11, Plateau de Moulon, 91400, Orsay, France

    Nathalie Lévêque

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  1. Ahmad Bitar
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  2. Nadiah Zafar
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  3. Jean Pierre Valour
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  10. Abdelhamid Elaissari
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Correspondence to Abdelhamid Elaissari.

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Bitar, A., Zafar, N., Valour, J.P. et al. Elaboration of sponge-like particles for textile functionalization and skin penetration. Colloid Polym Sci 293, 2967–2977 (2015). https://doi.org/10.1007/s00396-015-3704-7

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  • DOI: https://doi.org/10.1007/s00396-015-3704-7

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