Colloid and Polymer Science

, Volume 292, Issue 1, pp 251–255 | Cite as

Silica nanocapsules for redox-responsive delivery

  • Johannes Fickert
  • David Schaeffel
  • Kaloian Koynov
  • Katharina Landfester
  • Daniel CrespyEmail author
Short Communication


Redox-responsive silica nanocapsules with a hydrophobic liquid core were synthesized by reactive templating of miniemulsion droplets with functional alkoxysilanes. Tetrasulfide bridges were successfully introduced into the inorganic shell and were found to be accessible for chemical reactions as shown by 31P-NMR spectroscopy. Indeed, the tetrasulfide groups could be reduced to yield thiol groups. A subsequent increase of permeability of the silica shell was observed upon reduction of the tetrasulfide groups.


Encapsulation Miniemulsion Nanocapsules Nanoparticles Redox-responsive 



Sabrina Brand is acknowledged for her help in the project. Financial support from the DFG (SPP1568) and the joint cooperation program between the Fraunhofer and the Max Planck Societies are also acknowledged.

Supplementary material

396_2013_3105_MOESM1_ESM.docx (266 kb)
ESM 1 experimental section, chemical strcutures of the alkoxysilanes, scheme of the reduction reaction, TEM and SEM micrographs of functional silica nanocaspules, and evaluation procedure of the FCS data. (DOCX 265 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Johannes Fickert
    • 1
  • David Schaeffel
    • 1
  • Kaloian Koynov
    • 1
  • Katharina Landfester
    • 1
  • Daniel Crespy
    • 1
    Email author
  1. 1.Max Planck Institute for Polymer ResearchMainzGermany

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