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Colloid and Polymer Science

, Volume 292, Issue 1, pp 33–50 | Cite as

Biofunctionalisation of colloidal gold nanoparticles via polyelectrolytes assemblies

  • Sónia O. Pereira
  • Ana Barros-Timmons
  • Tito TrindadeEmail author
Review Article

Abstract

Bioapplications of gold nanoparticles (Au NPs) have received significant attention due to their sensitive optical characteristics which depend on particle size and shape, state of aggregation and to surrounding (bio)chemical environment. In this review, we present an overview of several methods to synthesise stable colloidal Au NPs with focus on the use of the electrostatic assembly method of polyelectrolytes (PE) to functionalise Au NPs. This versatile method allows adjusting the thickness, chemical functions and the surface charge of the shells surrounding the Au NPs, thus the relevance of these features for the bioapplications of Au NPs involving surface-mediated processes is discussed. Moreover, because the PE used can be functionalised with organic fluorophores, drugs or antibodies yielding multifunctional nanocomposites useful for those applications, this review also provides an overview of the electrostatic assembly of functionalised PE onto Au NPs and their bioapplications.

Keywords

Gold colloids Polyelectrolytes Plasmonics Biofunctionalisation Bioapplications 

Abbreviations

B-PEI

Branched poly(ethylenimine)

DMAP

(4-(dimethylamino)pyridine)

DNA

Deoxyribonucleic acid

EDC

(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

FITC

Fluorescein isothiocyanate

HPMA

N-(2-hydroxypropyl)methacrylamide

IgG

Immunoglobulin G

LISS

Lissamine rhodamine B

L-PEI

Linear poly(ethyleneimine)

MUA

Mercaptoundecanoic acid

NHS

N-hydroxysuccinimide

NPs

Nanoparticles

PAA

Poly(allylamine)

PAAcid

Poly(acrylic acid)

PAH

Poly(allylamine hydrochloride)

PBS

Phosphate-buffered saline

PCs/NP

Polyelectrolyte chains per NPs

PDADMAC

Poly(diallyldimethylammonium chloride)

PE

Polyelectrolyte

PEI

Poly(ethyleneimine)

PLL

Poly(L-lysine)

PSS

Poly(styrenesulfonic acid sodium salt)

Si-PEI

N-[3-(trimethoxysilyl)propyl] poly(ethylenimine)

SPR

Surface plasmon resonance

siRNA

Small interfering RNA

TEM

Transmission electron microscopy

Notes

Acknowledgments

Sónia Pereira thanks Fundação para a Ciência e Tecnologia (FCT) for the grant SFRH/BD/80156/2011. CICECO acknowledges funding from FCT, FSE and POPH (Pest-C/CTM/LA0011/2011 project).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Sónia O. Pereira
    • 1
  • Ana Barros-Timmons
    • 1
  • Tito Trindade
    • 1
    Email author
  1. 1.Department of Chemistry-CICECO Aveiro Institute of NanotechnologyUniversity of AveiroAveiroPortugal

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