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Synthesis and drug release properties of novel pH- and temperature-sensitive copolymers based on a hyperbranched polyether core

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Abstract

Multi-arm star amphiphilic hyperbranched copolymers with poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) shell and hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane) (HBPO) core were synthesized by reversible addition–fragmentation chain transfer method. The hyperbranched copolymers were further modified by succinic anhydride (SUC) to obtain the novel pH- and thermosensitive hyperbranched copolymer HBPO-star-PDMAEMAs-SUC. The composition and morphology of synthesized copolymers were investigated by 1H NMR, dynamic light scattering, and transmission electron microscopy. These copolymers exhibited phase transitions in response to pH and temperature. The pH-dependent release properties of the drug-loaded micelles were also investigated using indomethacin (IND) as a model drug. The IND-loaded micelles displayed a rapid drug release at an alkaline pH.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (20604024), Natural Science Foundation of Zhejiang Province (Y4100045), Qianjiang Talents Project of Zhejiang Province (2010R10023), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (1001603-C), Scientific Research Foundation of Zhejiang Sci-Tech University (0901808-Y), Key Bidding Project of Zhejiang Provincal Key Lab of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University (S2010002), and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT: 0654).

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Authors and Affiliations

  1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Xinke Sun, Guohua Jiang, Yin Wang & Yunzhu Xu

  2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Xinke Sun, Guohua Jiang, Yin Wang & Yunzhu Xu

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  1. Xinke Sun
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  2. Guohua Jiang
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  3. Yin Wang
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  4. Yunzhu Xu
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Correspondence to Guohua Jiang.

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Sun, X., Jiang, G., Wang, Y. et al. Synthesis and drug release properties of novel pH- and temperature-sensitive copolymers based on a hyperbranched polyether core. Colloid Polym Sci 289, 677–684 (2011). https://doi.org/10.1007/s00396-010-2314-7

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  • DOI: https://doi.org/10.1007/s00396-010-2314-7

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