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Synthesis and characterization of novel core-shell colloidal particles ZnO/poly(ethylcyanoacrylate)

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Abstract

Here we report the synthesis and physicochemical characterization of novel hybrid core/shell type ZnO/poly(ethylcyanoacrylate) colloidal particles. It is expected that coating ZnO colloidal particles with biocompatible and biodegradable poly(alkylcyanoacrylates) will pave the way toward the potential application of ZnO colloidal particles in biomedical research. Recent findings of cell selective toxicity indicate a potential utilization of ZnO colloidal particles in the treatment of cancer. For this purpose, ZnO colloidal particles have to be selectively delivered to the site of action by a suitable biocompatible and biodegradable carrier system. Toward this goal, poly(alkylcyanoacrylates) meet ideally the requirements for carrier systems in drug delivery due to their biocompatibility, biodegradability, low toxicity, and ability to overcome the multidrug resistance in cancer cells.

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Acknowledgements

The financial support by the University of Sofia (project 89/2008) and the Bulgarian Ministry of Education and Science (Projects VUH-09/05 and TK-X-1702/07) is greatly acknowledged.

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Authors and Affiliations

  1. Department of General and Inorganic Chemistry, Laboratory of Nanoparticle Science and Technology, University of Sofia, Faculty of Chemistry, 1 James Boucher Blvd, Sofia, 1164, Bulgaria

    Georgi G. Yordanov, Nina V. Kaneva & Ceco D. Dushkin

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  1. Georgi G. Yordanov
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  2. Nina V. Kaneva
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  3. Ceco D. Dushkin
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Correspondence to Ceco D. Dushkin.

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Yordanov, G.G., Kaneva, N.V. & Dushkin, C.D. Synthesis and characterization of novel core-shell colloidal particles ZnO/poly(ethylcyanoacrylate). Colloid Polym Sci 287, 733–738 (2009). https://doi.org/10.1007/s00396-009-2034-z

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  • DOI: https://doi.org/10.1007/s00396-009-2034-z

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