Skip to main content
SpringerLink
Log in

Microgel, nanogel and hydrogel–hydrogel semi-IPN composites for biomedical applications: synthesis and characterization

  • Original Contribution
  • Published:
Colloid and Polymer Science Aims and scope Submit manuscript

Abstract

Quaternary ammonium salt hydrogels from a cationic monomer, (3-acrylamidopropyl)-trimethylammonium chloride (APTMACl), in a variety sizes such as bulk, micro- and nano- has been prepared. The synthesis of micro- and nanogels were carried out in the microenvironment of water-in-oil microemulsions using two types of surfactants, namely, L-α- phosphatidylcholine (lecithin) and dioctyl sulfosuccinate sodium salt (AOT). Additionally, hydrogel–hydrogel composite semi-interpenetrating polymer networks (semi-IPN) was synthesized by dispersing previously prepared micro/nanogel into neutral monomers such as acrylamide (AAm) or 2-hydroxylethyl methcarylate (HEMA) before network formation. Hydrogel swelling and pH response behaviors have been investigated for bulk gels. Morphology, structure, and size of nano-, micro- and bulk materials were explored utilizing transmission electron microcopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM). It was confirmed with gel electrophoresis that completely charged nanogel form a strong complex with DNA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Scheme 2
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Janusz MR, Yoshii F (1999) Nucl Instrum Methods Phys Res B 151:56

    Article  Google Scholar 

  2. Nicholas AP, William L (2004) J Biomater Sci Polym Ed 15:125

    Article  Google Scholar 

  3. Karlsson OJ, Gatenholm P (1997) Polymer 38:4727

    Article  CAS  Google Scholar 

  4. Jing Z, Nicholas AP (2000) Macromolecules 33:102

    Article  Google Scholar 

  5. Yoshihito O, Jian-ping G (1998) Adv Mater 10:827

    Article  Google Scholar 

  6. Jun C, Haesun P, Kinam P (1999) J Biomed Mater Res 44:53

    Article  Google Scholar 

  7. Zhao B, Moore SJ (2001) Langmuir 17:4758

    Article  CAS  Google Scholar 

  8. Karlsson JO, Andersson M, Berntsson P, Chihani T, Gatenholm P (1998) Polymer 39:3589

    Article  CAS  Google Scholar 

  9. Fumiyoshi I, Naoki M, Takeshi K, Sachio N, Kimio K, Mitsuhiro S (2003) Langmuir 19:2568

    Article  Google Scholar 

  10. Zrínyi M (2000) Colloid Polym Sci 278:98

    Article  Google Scholar 

  11. Marieta N, Zhu XX, Wilms B, Doina C, Adrian C (2001) J Pharm Sci 90:681

    Article  Google Scholar 

  12. Vladimir GS, Olga AN, Olga AP, Anatoly AZ, Valentina BR, Alexander BZ, Kenichi Y, Victor AK (2002) J Am Chem Soc 124:11324

    Article  Google Scholar 

  13. Rosso AB, Barbarisi M, Petillo O, Margarucci S, Calarco A, Peluso G (2003) Mater Sci Eng C 23:371

    Article  Google Scholar 

  14. Stefaan CDS, Joseph D, Wim EH (2000) Pharm Res 17:113

    Article  Google Scholar 

  15. Jaroslav B, Ignác C (2000) Macromolecules 33:5353

    Article  Google Scholar 

  16. Giammona G, Cavallaro G, Pitaressi G, Pedone E (2000) Colloid Polym Sci 278:69

    Article  CAS  Google Scholar 

  17. Sergey K, Marian K, Iwao T, Kalle L (2002) Macromolecules 35:1911

    Article  Google Scholar 

  18. Norton LV, Tengell E, Toporek SS, Reichert WM (2005) Biomaterials 26:3285

    Article  CAS  Google Scholar 

  19. Jason EM, Matthew JS, Scott MG, Benjamin MR, David MJ, Romy K, Ramakrishnan K, Kalpana M, Benjamin H, Zachary LH, Andrew DE, Michal VP, Grant CW (2004) Chem Mater 16:5574

    Article  Google Scholar 

  20. Bouillot P, Vincet B (2000) Colloid Polym Sci 278:74

    Article  CAS  Google Scholar 

  21. Isamu K, Atsushi S, Hideo N (2004) J Colloid Interface Sci 175:450

    Google Scholar 

  22. Andreas R, David H (1999) Polymer 40:3545

    Article  Google Scholar 

  23. Essler F, Candau F (2001) Colloid Polym Sci 279:405

    Article  CAS  Google Scholar 

  24. Braun O, Selb J, Canadu F (2001) Polymer 42:8499

    Article  CAS  Google Scholar 

  25. Sanjeeb KS, Tapas KD, Ghosh PK, Amarnath M (1998) J Colloid Interface Sci 206:361

    Article  Google Scholar 

  26. Hennik WE, Nostrun VCF (2002) Adv Drug Deliv Rev 54:13

    Article  Google Scholar 

  27. Soppimath KS, Aminabhavi TM, Dave AM, Kumbar SG, Rudzinski WE (2002) Drug Devel Ind Pharm 28:957

    Article  CAS  Google Scholar 

  28. Daoji G, Andrew LL (2001) J Am Chem Soc 123:7511

    Article  Google Scholar 

  29. Saraydin D, Karadag E, Guven O (1995) Polym Adv Technol 6:719

    Article  CAS  Google Scholar 

  30. Donald V, Judith GV, Charlotte WP (1999) Fundamentals of biochemistry. Wiley, Ch 9:219–238

  31. Ignacio de M, Laurent I, Valerie R, Michel M, Roger K, Didier B (2000) Pharma Res 17:817

    Article  Google Scholar 

  32. Maria JV, Rutger WHMS, Willem JMM, Arno SD, Bart AJJ, Ben de K, Anton IPMde K (2004) Biochim Biophys Acta 1663:135

    Article  Google Scholar 

  33. Koert NJB, Rutger WHM, Hanke CDV, Maria JV, Paul HB, Peter MF, Ben DK (2002) Nat Med 8:81

    Article  Google Scholar 

  34. Fenart L, Casanova A, Dehouck B, Duhem C, Slupek S, Cecchelli R, Betbeder D (1999) J Pharmacol Exp Ther 291:1017

    CAS  Google Scholar 

  35. ElJarrat-Binstock E, Raiskup F, Frucht-Pery J, Domb AJ (2004) J Biomater Sci Polym Ed 15:397

    Article  CAS  Google Scholar 

  36. McAllister K, Peter S, Mirielle A, Moo JC, Michael R, Richard JS, Joseph MD (2002) J Am Chem Soc 124:15198

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Tulane Institute for Macromolecular Engineering and Science (TIMES) and Coordinated Instrumentation Facility (CIF) at Tulane University.

Author information

Authors and Affiliations

  1. Department of Chemical & Biomolecular Engineering, Tulane University, New Orleans, LA, 70118, USA

    Nurettin Sahiner, W. T. Godbey & Vijay T. John

  2. Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA

    Gary L. McPherson

  3. Materials Science and Engineering, University of Delaware, 201 DuPont Hall, Newark, DE, 19716, USA

    Nurettin Sahiner

Authors
  1. Nurettin Sahiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. T. Godbey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gary L. McPherson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vijay T. John
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nurettin Sahiner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sahiner, N., Godbey, W.T., McPherson, G.L. et al. Microgel, nanogel and hydrogel–hydrogel semi-IPN composites for biomedical applications: synthesis and characterization. Colloid Polym Sci 284, 1121–1129 (2006). https://doi.org/10.1007/s00396-006-1489-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00396-006-1489-4

Keywords

Search

Navigation