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Novel temperature-sensitive, β-cyclodextrin-incorporated poly(N-isopropylacrylamide) hydrogels for slow release of drug

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Abstract

Novel temperature-sensitive poly(N-isopropylacrylamide) hydrogels containing water-soluble β-cyclodextrin polymer were prepared by forming semi-interpenetrating polymeric networks. Compared to the conventional poly(N-isopropylacrylamide) gel, the β-cyclodextrin-incorporated hydrogels showed the same lower critical solution temperature due to the independence of the β-cyclodextrin polymer in the networks. The release time of ibuprofen from the novel gel was significantly prolonged, which was presumably attributed to the formation of the inclusion complexes between the cyclodextrin groups and the drug molecules.

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Acknowledgements

The authors thank National Key Basic Research Program of China (973 Program) (G1999064703) and National Natural Science Foundation of China (20204009) for the financial support.

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Authors and Affiliations

  1. Key Laboratory of Biomedical Polymers, Ministry of Education; Department of Chemistry, Wuhan University, Wuhan, 430072, Peoples Republic of China

    Jian-Tao Zhang, Shi-Wen Huang, Fa-Zhi Gao & Ren-Xi Zhuo

Authors
  1. Jian-Tao Zhang
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  2. Shi-Wen Huang
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  3. Fa-Zhi Gao
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  4. Ren-Xi Zhuo
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Corresponding author

Correspondence to Ren-Xi Zhuo.

Additional information

Jian-Tao Zhang and Shi-Wen Huang have contributed equally to this work.

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Zhang, JT., Huang, SW., Gao, FZ. et al. Novel temperature-sensitive, β-cyclodextrin-incorporated poly(N-isopropylacrylamide) hydrogels for slow release of drug. Colloid Polym Sci 283, 461–464 (2005). https://doi.org/10.1007/s00396-004-1224-y

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  • DOI: https://doi.org/10.1007/s00396-004-1224-y

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