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A new approach for the characterization of insoluble amphiphilic copolymers based on their emulsifying properties

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Abstract

The purpose of the present study was to propose a new approach for the characterization of insoluble amphiphilic copolymers using their emulsifying properties. The capacity of four newly-synthesized block copolymers to stabilize a model emulsion formed by mixing equal volumes of water and ethyl acetate was investigated. The copolymers were composed of dextran or heparin and poly(isobutylcyanoacrylate) and were obtained either by anionic or by radical polymerization of isobutylcyanoacrylate in emulsion, initiated on dextran or heparin. A quantitative analysis of the stability of the emulsion obtained with the different copolymers was evaluated using a Turbiscan MA 2000. The results suggested that this approach provides a new methodology for investigating emulsifying properties of polymers that are insoluble in pure solvents, allowing quantitative comparisons to be made between them.

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Acknowledgements

The authors are very grateful to Dr. A. De Sainte Marie, Formulaction (Toulouse, France) for lending us the Tubiscan MA 2000, and to Dr. K. Broadley, Loctite (Dublin, Ireland) for providing us with isobutylcyanoacrylate. The authors would also like to thank Dr. N. Mignard, Formulaction (Toulouse, France) for his careful reading of the part of the manuscript explaining the principle of the measurements. Cédric Chauvierre was a fellow of the Ministry of Research, France.

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Paris XI, UMR CNRS 8612, 5 rue J.B. Clément, 92296 , Châtenay-Malabry Cedex, France

    Cédric Chauvierre, Denis Labarre, Patrick Couvreur & Christine Vauthier

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  1. Cédric Chauvierre
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  2. Denis Labarre
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  3. Patrick Couvreur
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  4. Christine Vauthier
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Correspondence to Christine Vauthier.

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Chauvierre, C., Labarre, D., Couvreur, P. et al. A new approach for the characterization of insoluble amphiphilic copolymers based on their emulsifying properties. Colloid Polym Sci 282, 1097–1104 (2004). https://doi.org/10.1007/s00396-003-1040-9

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  • DOI: https://doi.org/10.1007/s00396-003-1040-9

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