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Two-dimensional auto-organized nanostructure of sodium hyaluronate and its frictional properties

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Abstract

The two-dimensional auto-organized nanostructure of sodium hyaluronate NaHA on bovine serum albumin BSA monolayer was studied by a layer-by-layer method. The surface properties were studied by a quartz crystal microbalance QCM method and by using an atomic force microscope AFM. NaHA showed a Langmuir-type adsorption and was found to form honeycomb-like networks. With increasing adsorption amount Γ of NaHA, their mesh size decreased and their strand size increased in width. The surface nanomechanical properties, such as adhesion force F ad and frictional forces F f between the surfaces of the NaHA layers and the AFM tip, were studied in air and in NaHA solutions using a contact mode and a lateral force modulation LFM of AFM. The values of F ad and F f obtained in air were found to be higher than those obtained in the solutions because of the effect of moisture film on the NaHA layers. The values of F ad and frictional coefficients in the solutions increased with increasing Γ.

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Acknowledgements

This research was supported by a grant from Japan Society for the Promotion of Science (JSPS,ID No. P 02183) and the Japan Health Sciences Foundation. Our thanks are extended to Seikagaku Kogyo Co., Ltd. for supplying NaHA samples.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori Mizuho-ku, 467-8603, Nagoya, Japan

    S. Xu, J. Yamanaka, S. Sato, I. Miyata & M. Yonese

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  1. S. Xu
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  2. J. Yamanaka
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  3. S. Sato
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  4. I. Miyata
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  5. M. Yonese
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Correspondence to S. Xu.

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Xu, S., Yamanaka, J., Sato, S. et al. Two-dimensional auto-organized nanostructure of sodium hyaluronate and its frictional properties. Colloid Polym Sci 282, 440–445 (2004). https://doi.org/10.1007/s00396-003-0964-4

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  • DOI: https://doi.org/10.1007/s00396-003-0964-4

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