Abstract
This review describes the temporal changes of high-energy phosphate metabolites during the cardiac cycle. Under baseline condition, the extent of cyclical changes (“cycling”) of ATP, phosphocreatine and inorganic phosphate varies between 10–15 %. Such energy oscillations are not augmented under various forms of metabolic stress including 1) inotropic stimulation, 2) acute hypoxia and 3) failing, chronically infarcted hearts. Thus, the concentrations of high-energy phosphates over the cardiac cycle are a tightly regulated entity, even when energetic needs are substantially augmented.
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Received: 28 February 2001, Returned for revision: 17 May 2001, Revision received: 25 June 2001, Accepted: 12 July 2001
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Spindler, M., Illing, B., Horn, M. et al. Temporal fluctuations of myocardial high-energy phosphate metabolites with the cardiac cycle. Basic Res Cardiol 96, 553–556 (2001). https://doi.org/10.1007/s003950170006
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DOI: https://doi.org/10.1007/s003950170006