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Rp-cAMPS has ho effect on adenosine A1 receptors in guinea-pig cardiomyocytes

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Abstract

Rp-cAMPS, a protein kinase A inhibitor, is used in the investigation of the cAMP-dependent systems. A report by Musgrave et al. (11) has suggested that Rp-cAMPS may also act on adenosine receptors. To determine whether this occurs in guinea-pig ventricular myocytes, Rp-cAMPS was applied in the presence and absence of DCPCX, an adenosine A1 receptor antagonist. The isoprenaline-induced response was significantly decreased by Rp-cAMPS and the effect was not altered by the presence of DCPCX. Therefore Rp-cAMPS has no effect on cell contraction via adenosine A1 receptors and can reliably be used to investigate cyclic AMP-dependent systems in isolated cardiac myocytes.

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Authors and Affiliations

  1. Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK, E-mail: d.adamson@ic.ac.uk, , , , , , GB

    Dawn L. Adamson & Sian E. Harding

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  1. Dawn L. Adamson
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  2. Sian E. Harding
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Received: 23 April 1999, Returned for 1. revision: 26 May 1999, 1. Revision received: 23 August 1999, Returned for 2. revision: 28 September 1999, 2. Revision received: 15 November 1999, Accepted: 17 November 1999

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Adamson, D., Harding, S. Rp-cAMPS has ho effect on adenosine A1 receptors in guinea-pig cardiomyocytes. Basic Res Cardiol 95, 114–118 (2000). https://doi.org/10.1007/s003950050172

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  • DOI: https://doi.org/10.1007/s003950050172

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