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Effects of resistant starch on glycemic response, postprandial lipemia and appetite in subjects with type 2 diabetes

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Abstract

Purpose

Resistant starch (RS) content has exhibited beneficial effects on glycemic control; however, few studies have investigated the effects of this substance on postprandial responses and appetite in subjects with type 2 diabetes (T2D). Here, we aimed to examine the effects of RS from two sources on glycemic response (GR), postprandial lipemia, and appetite in subjects with T2D.

Methods

In a randomized and crossover study, 17 subjects with T2D consumed native banana starch (NBS), high-amylose maize starch (HMS) or digestible maize starch (DMS) for 4 days. On day 5, a 6-h oral meal tolerance test (MTT) was performed to evaluate glycemic and insulinemic responses as well as postprandial lipemia. Besides, subjective appetite assessment was measured using a visual analogue scale.

Results

NBS induced a reduction on fasting glycemia, glycemia peak and insulinemic response during MTT. However, no modifications on postprandial lipemia were observed after RS treatments. Both NBS and HMS reduced hunger and increased satiety.

Conclusion

NBS supplementation induced more beneficial effects on glycemic metabolism than HMS even when all interventions were matched for digestible starch content. RS intake did not modify postprandial lipemia, however, positively affected subjective appetite rates.

Trial registration: This trial was retrospectively registered at www.anzctr.org.au (ACTRN12621001382864) on October 11, 2021.

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Data availability

The dataset used in this publication is available from the corresponding author on reasonable request.

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Acknowledgements

Special thanks are extended to all the volunteers participating in this study.

Funding

This study was funded by the Programa de Fomento a la Investigación of the Universidad Juárez Autónoma de Tabasco (UJAT-DACS 2015-IA-09).

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Authors and Affiliations

  1. Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa, Tabasco, Mexico

    Carlos García-Vázquez, Jorge L. Ble-Castillo, Yolanda Arias-Córdova, Meztli Ramos-García, Viridiana Olvera-Hernández, Crystell G. Guzmán-Priego & Mirian C. Martínez-López

  2. Departamento de Medicina Interna, Hospital General de Zona No. 46, Instituto Mexicano del Seguro Social (IMSS), Villahermosa, Tabasco, Mexico

    Guadalupe Jiménez-Domínguez

  3. División de Tecnología de Alimentos, Universidad Tecnológica de Tabasco, Villahermosa, Tabasco, Mexico

    Josafat A. Hernández-Becerra

Authors
  1. Carlos García-Vázquez
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  2. Jorge L. Ble-Castillo
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Contributions

The authors’ responsibilities were as follows—JLB-C, CG-V: contributed to the conceptualization of the manuscript; CG-V, YA-C, and GJ-D: contributed to the methodology; MCM-L, and CGG-P: contributed to the software; CG-V, and VO-H: contributed to the validation; CG-V, JLB-C, YA-C, and MR-G: contributed to the formal analysis; GJ-D, and MR-G: contributed to the investigation; JLB-C, CG-V, and CGG-P: contributed to the data curation; JLB-C, and MR-G: contributed to the writing—original draft preparation; JLB-C, CG-V, and JAH-B: contributed to the writing—review and editing. MCM-L, GJ-D, and JAH-B: contributed to the supervision. All authors have approved the final article for publication.

Corresponding author

Correspondence to Jorge L. Ble-Castillo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethical Committee of the Instituto Mexicano del Seguro Social (Registration number 2015-2701-17, Approved on November, 2015).

Informed consent

Informed consent was obtained from all subjects involved in the study.

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García-Vázquez, C., Ble-Castillo, J.L., Arias-Córdova, Y. et al. Effects of resistant starch on glycemic response, postprandial lipemia and appetite in subjects with type 2 diabetes. Eur J Nutr 62, 2269–2278 (2023). https://doi.org/10.1007/s00394-023-03154-4

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  • DOI: https://doi.org/10.1007/s00394-023-03154-4

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