Abstract
Aim
Oral caffeine intake has been deemed as an effective supplementation strategy to enhance fat oxidation during aerobic exercise with a steady-state intensity. However, in real exercise scenarios, individuals habitually train with autoregulation of exercise intensity. This study aimed to analyze the effect of oral caffeine intake during self-paced cycling on autoregulated exercise intensity and substrate oxidation.
Methods
Fifteen young and healthy participants (11 men and 4 women) participated in a double-blind, randomized, cross-over investigation. Each participant took part in 2 experimental days consisting of pedaling for 1 h with a self-selected wattage. Participants were told that they had to exercise at a moderate intensity to maximize fat oxidation. On one occasion participants ingested 3 mg/kg of caffeine and on the other occasion ingested a placebo. Energy expenditure, fat oxidation rate, and carbohydrate oxidation rate were continuously measured during exercise by indirect calorimetry.
Results
In comparison to the placebo, caffeine intake increased the self-selected wattage (on average, 105 ± 44 vs 117 ± 45 W, respectively, P < 0.001) which represented a higher total work during the cycling session (377 ± 157 vs 422 ± 160 kJ, P < 0.001). Caffeine increased total energy expenditure (543 ± 161 vs 587 ± 155 kcal, P = 0.042) but it did not affect total fat oxidation (24.7 ± 12.2 vs 22.9 ± 11.5 g, P = 0.509) or total carbohydrate oxidation (87.4 ± 22.4 vs 97.8 ± 32.3 g, P = 0.101).
Conclusion
Acute caffeine ingestion before an exercise session with an individual's freedom to regulate intensity induces a higher self-selected exercise intensity and total work. The selection of a higher exercise intensity augments total energy expenditure but eliminates the effect of caffeine on substrate oxidation during exercise.
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References
Maughan RJ, Burke LM, Dvorak J et al (2018) IOC consensus statement: dietary supplements and the high-performance athlete. Br J Sports Med 52:439 LP – 455. https://doi.org/10.1136/bjsports-2018-099027
Grgic J, Grgic I, Pickering C et al (2019) Wake up and smell the coffee: Caffeine supplementation and exercise performance—an umbrella review of 21 published meta-analyses. Br J Sports Med 54:681–688. https://doi.org/10.1136/bjsports-2018-100278
Salinero JJ, Lara B, Del Coso J (2019) Effects of acute ingestion of caffeine on team sports performance: a systematic review and meta-analysis. Res Sport Med. 27:238–256. https://doi.org/10.1080/15438627.2018.1552146
Gutiérrez-Hellín J, Del Coso J (2018) Effects of p-synephrine and caffeine ingestion on substrate oxidation during exercise. Med Sci Sport Exerc 50:1899–1906. https://doi.org/10.1249/MSS.0000000000001653
Ruiz-Moreno C, Gutiérrez-Hellín J, Amaro-Gahete FJ et al (2020) Caffeine increases whole-body fat oxidation during 1 h of cycling at Fatmax. Eur J Nutr. https://doi.org/10.1007/s00394-020-02393-z
Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Del Coso J (2020) Effect of acute caffeine intake on the fat oxidation rate during exercise: a systematic review and meta-analysis. Nutrients 12:1–18. https://doi.org/10.3390/nu12123603
Ramírez-Maldonado M, Jurado-Fasoli L, del Coso J et al (2021) Caffeine increases maximal fat oxidation during a graded exercise test: is there a diurnal variation? J Int Soc Sports Nutr. https://doi.org/10.1186/s12970-020-00400-6
Costill DL, Dalsky GP, Fink WJ (1978) Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports 10:155–158
Essig D, Costill D, Van Handel P (1980) Effects of caffeine ingestion on utilization of muscle glycogen and lipid during leg ergometer cycling. Int J Sports Med 01:86–90. https://doi.org/10.1055/s-2008-1034637
Ivy JL, Costill DL, Fink WJ, Lower RW (1979) Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports 11:6–11
Glaister M, Pattison JR, Muniz-Pumares D et al (2015) Effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance. J Strength Cond Res 29:165–174. https://doi.org/10.1519/JSC.0000000000000596
Green J, Olenick A, Eastep C, Winchester L (2016) Caffeine effects on velocity selection and physiological responses during RPE production. Appl Physiol Nutr Metab 41:1077–1082. https://doi.org/10.1139/APNM-2016-0098
Purdom T, Kravitz L, Dokladny K, Mermier C (2018) Understanding the factors that effect maximal fat oxidation. J Int Soc Sports Nutr 15:3. https://doi.org/10.1186/s12970-018-0207-1
Doherty M, Smith PM (2005) Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports 15:69–78. https://doi.org/10.1111/j.1600-0838.2005.00445.x
Filip A, Wilk M, Krzysztofik M, Del Coso J (2020) Inconsistency in the ergogenic effect of caffeine in athletes who regularly consume caffeine: is it due to the disparity in the criteria that defines habitual caffeine intake? Nutrients 12:1087. https://doi.org/10.3390/nu12041087
Brouwer E (1957) On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidized in metabolism of men and animals, from gaseous exchange (Oxygen intake and carbonic acid output) and urine-N. Acta Physiol Pharmacol Neerl 6:795–802
Frayn KN (2016) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol
Edvardsen E, Hem E, Anderssen SA (2014) End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study. PLoS ONE. https://doi.org/10.1371/journal.pone.0085276
Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc. https://doi.org/10.1249/00005768-198205000-00012
Salinero JJ, Lara B, Abian-Vicen J et al (2014) The use of energy drinks in sport: perceived ergogenicity and side effects in male and female athletes. Br J Nutr 112:1494–1502. https://doi.org/10.1017/S0007114514002189
Burke LM, Hawley JA, Wong SHS, Jeukendrup AE (2011) Carbohydrates for training and competition. J Sports Sci 29:S17–S27. https://doi.org/10.1080/02640414.2011.585473
McDermott BP, Anderson SA, Armstrong LE et al (2017) National athletic trainers’ association position statement: fluid replacement for the physically active. J Athl Train 52:877–895. https://doi.org/10.4085/1062-6050-52.9.02
Casa DJ, Armstrong LE, Hillman SK et al (2000) National athletic trainers’ association position statement: fluid replacement for athletes. J Athl Train 35:212–224
Ruiz-Moreno C, Lara B, Salinero JJ et al (2020) Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine. Eur J Nutr. https://doi.org/10.1007/s00394-019-02167-2
McCall AL, Millington WR, Wurtman RJ (1982) Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport. Life Sci 31:2709–2715. https://doi.org/10.1016/0024-3205(82)90715-9
Meeusen R, Roelands B, Spriet LL (2013) Caffeine, exercise and the brain. Nestle Nutr Inst Workshop Ser 76:1–12. https://doi.org/10.1159/000350223
Killen LG, Green JM, O’Neal EK et al (2013) Effects of caffeine on session ratings of perceived exertion. Eur J Appl Physiol 113:721–727. https://doi.org/10.1007/s00421-012-2480-z
Lara B, Ruiz-Moreno C, Salinero JJ, Del Coso J (2019) Time course of tolerance to the performance benefits of caffeine. PLoS ONE 14:e0210275. https://doi.org/10.1371/journal.pone.0210275
Ruiz-moreno C, Lara B, Gutiérrez-hellín J et al (2020) Time course and magnitude of tolerance to the ergogenic effect of caffeine on the second ventilatory threshold. Life 10:1–12. https://doi.org/10.3390/life10120343
Donelly K, McNaughton L (1992) The effects of two levels of caffeine ingestion on excess postexercise oxygen consumption in untrained women. Eur J Appl Physiol Occup Physiol 65:459–463. https://doi.org/10.1007/BF00243514
Graham TE, Spriet LL (1995) Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. J Appl Physiol 78:867–874. https://doi.org/10.1152/jappl.1995.78.3.867
Lara B, Salinero JJ, Giráldez-Costas V, Del Coso J (2021) Similar ergogenic effect of caffeine on anaerobic performance in men and women athletes. Eur J Nutr 60:4107–4114. https://doi.org/10.1007/s00394-021-02510-6
Skinner TL, Desbrow B, Arapova J et al (2019) Women experience the same ergogenic response to caffeine as men. Med Sci Sport Exerc. https://doi.org/10.1249/MSS.0000000000001885
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The authors wish to thank the subjects for their invaluable contribution to the study.
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Ruiz-Moreno, C., Amaro-Gahete, F.J., González-García, J. et al. Caffeine increases exercise intensity and energy expenditure but does not modify substrate oxidation during 1 h of self-paced cycling. Eur J Nutr 61, 3285–3292 (2022). https://doi.org/10.1007/s00394-022-02894-z
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DOI: https://doi.org/10.1007/s00394-022-02894-z