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Emerging cardioprotective mechanisms of vitamin B6: a narrative review

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Abstract

Although overt vitamin B6 deficiency is rare, marginal vitamin B6 deficiency is frequent and occurs in a consistent proportion of the population. The marginal vitamin B6 deficiency appears to relate to an increased risk of inflammation-related diseases, such as cardiovascular diseases and cancers. Of all the cardiovascular diseases, heart failure is a complex clinical syndrome associated with a high mortality rate. So far, information regarding the cardioprotective mechanisms of vitamin B6 has been limited. Meanwhile, recent studies have revealed that vitamin B6 treatment increases cardiac levels of imidazole dipeptides (e.g., carnosine, anserine, and homocarnosine), histamine, and γ-aminobutyric acid (GABA) and suppresses P2X7 receptor-mediated NLRP3 inflammasome. These modulations may imply potential cardioprotective mechanisms of vitamin B6. These modulations may also be involved in the underlying mechanisms through which vitamin B6 suppresses oxidative stress and inflammation. This review provides an up-to-date evaluation of our current understanding of the cardioprotective mechanisms of vitamin B6.

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Acknowledgements

This study was financially supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by the HIRAKU consortium, Hiroshima University. The authors would like to thank Enago (www.enago.jp) for English language review.

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Authors and Affiliations

  1. Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, 739-8528, Japan

    Thanutchaporn Kumrungsee, Noriyuki Yanaka & Norihisa Kato

  2. State Key Laboratory of Cellular Stress Biology, School of Medicine & School of Life Science, Xiamen University, Xiamen, Fujian, China

    Peipei Zhang

  3. Department of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

    Takashi Suda

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Review conception: TK, PZ and NK; literature search: TK, PZ and NK; writing of the manuscript: TK, PZ, NY, TS, and NK.

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Correspondence to Thanutchaporn Kumrungsee or Norihisa Kato.

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Kumrungsee, T., Peipei Zhang, Yanaka, N. et al. Emerging cardioprotective mechanisms of vitamin B6: a narrative review. Eur J Nutr 61, 605–613 (2022). https://doi.org/10.1007/s00394-021-02665-2

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