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Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis

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Abstract

Purpose

Yeast β-glucans are known for their immune-modulating effects; however, their effects on human upper respiratory tract infections (URTIs) remain unclear. The aim of the present study was to use a systematic review and meta-analysis approach to investigate the effects of yeast β-glucans for the prevention and treatment of URTIs in healthy subjects.

Methods

Databases including Pubmed, Web of Science, EMBASE and the Cochrane Library were searched and 13 RCTs investigating the effects of yeast β-glucans on the incidence, duration, and severity of URTIs in healthy subjects were included.

Results

The results showed that compared to the placebo group, yeast β-glucan could significantly reduce the incidence of URTIs (OR = 0.345, 95% CI = 0.192 to 0.620, p < 0.001), decrease the average number of URTI episodes (SMD =  − 0.315, 95% CI =  − 0.500 to  − 0.130, p < 0.05), and decrease the duration of URTIs (SMD =  − 0.312, 95% CI =  − 0.561 to  − 0.064, p < 0.001). Improved severity of symptoms was found in yeast β-glucan group compared to the placebo group in the majority of included studies. In addition, yeast β-glucan was well tolerated and safe in general.

Conclusion

These findings suggest a positive effect of yeast β-glucans on human URTIs. However, due to the high heterogeneity and small number of included studies, more high-quality research and clinical trials are warranted.

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Authors and Affiliations

  1. Center for Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing, 210094, People’s Republic of China

    Kunxia Zhong, Zhiqin Liu, Yao Lu & Xi Xu

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  1. Kunxia Zhong
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  2. Zhiqin Liu
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  3. Yao Lu
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  4. Xi Xu
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Contributions

Conceptualization: XX, KXZ; study selection: KXZ, ZQL; data extraction and analysis: KXZ, ZQL, YL, XX; writing—original draft: KXZ, XX; writing—review ans editing: XX, ZQL, YL.

Corresponding author

Correspondence to Xi Xu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Appendix A

1. “upper respiratory tract infection”.

2. “common cold”.

3. “rhinitis”.

4. “pharyngitis”.

5. “rhino pharyngitis”.

6. “naso pharyngitis”.

7. “sinusitis”.

8. “rhino sinusitis”.

9. “naso sinusitis”.

10. “laryngitis”.

11. “tonsillitis”.

12. “nasal congestion”.

13. “nasal obstruction”.

14. “nose congestion”.

15. “nose obstruction”.

16. “rhinorrhea”.

17. “rhinovirus”.

18. “influenza”.

19. #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18

20. “β-glucan”.

21. “β-Glucan”.

22. “Βeta-glucan”.

23. “Βeta-Glucan”.

24. #20 OR #21 OR #22 OR #23

25. “randomized controlled trial”.

26. “controlled clinical trial”.

27. “random”.

28. “randomized”.

29. “randomly”.

30. “placebo”.

31. #25 OR #26 OR #27 OR #28 OR #29 OR #30

32. #19 AND #24 AND #31

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Zhong, K., Liu, Z., Lu, Y. et al. Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr 60, 4175–4187 (2021). https://doi.org/10.1007/s00394-021-02566-4

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