Skip to main content
Log in

Sodium and potassium intakes in the Kazakhstan population estimated using 24-h urinary excretion: evidence for national action

  • Original Contribution
  • Published:
European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

There is strong scientific evidence for reducing sodium and increasing potassium intake to the recommended levels to lower blood pressure and cardiovascular risk, but consumption levels in Kazakhstan are unknown. This study sought to estimate mean sodium and potassium intake using 24-h urine samples and describe dietary knowledge and behavior among adults in Kazakhstan.

Methods

In two cross-sectional surveys, the same multi-stage cluster sampling method was used to randomly select participants aged 25–64 years from Almaty City in 2015 and Kyzylorda in 2016. Complete 24-h urine samples were available for 478 participants; 294 in Almaty City and 184 in Kyzylorda (response rates 86% and 54%, respectively) and were weighted for the age and sex distribution of the two regions.

Results

Weighted mean 24-h urinary sodium excretion was 6782 mg/day (17.2 g salt) (95% CI 6507–7058) in both regions combined, and not significantly different between the regions (P = 0.660). 99% of adults in the two regions combined consumed above the World Health Organization’s (WHO) recommended sodium maximum of 2000 mg/day; however, only 15% of adults perceived that they consumed excess sodium. Weighted mean 24-h urinary potassium excretion was 2271 mg/day (95% CI 2151–2391) for the regions combined.

Conclusion

Mean sodium consumption in Kazakhstan was more than triple the WHO’s recommended maximum, and mean potassium consumption was below the recommended minimum. National efforts to lower sodium intake and increase potassium intake are needed and would likely prevent ample premature deaths and disease burden.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Institute for Health Metrics and Evaluation (2017) GBD compare. IHME, University of Washington. http://vizhub.healthdata.org/gbd-compare. Accessed 3 Nov 2017

  2. World Health Organization (2018) Noncommunicable disease country profiles 2018- Kazakhstan. World Health Organization. http://www.who.int/nmh/countries/2018/kaz_en.pdf. Accessed 21 Nov 2018

  3. He FJ, Li J, Macgregor GA (2013) Effect of longer term modest salt reduction on blood pressure: cochrane systematic review and meta-analysis of randomised trials. BMJ 346:f1325

    Article  Google Scholar 

  4. Newberry SJ, Chung M, Anderson CAM, Chen C, Fu Z, Tang A, Zhao N, Booth M, Marks J, Hollands S, Motala A, Larkin JK, Shanman R, Hempel S (2018) Sodium and potassium intake: effects on chronic disease outcomes and risks. Comparative Effectiveness Review No. 206. Agency for Healthcare Research and Quality. https://effectivehealthcare.ahrq.gov/topics/sodium-potassium/final-report-2018. Accessed 1 Sept 2018

  5. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ (2013) Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ 346:f1326. https://doi.org/10.1136/bmj.f1326

    Article  PubMed  PubMed Central  Google Scholar 

  6. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP (2013) Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ 346:f1378. https://doi.org/10.1136/bmj.f1378

    Article  PubMed  PubMed Central  Google Scholar 

  7. Huang L, Trieu K, Yoshimura S, Neal B, Woodward M, Campbell NRC, Li Q, Lackland DT, Leung AA, Anderson CAM, MacGregor GA, He FJ (2020) Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials. BMJ 368:m315. https://doi.org/10.1136/bmj.m315%JBMJ

    Article  PubMed  PubMed Central  Google Scholar 

  8. World Health Organization (2012) Guideline: sodium intake for adults and children. World Health Organization. http://apps.who.int/iris/bitstream/10665/77985/1/9789241504836_eng.pdf?ua=1&ua=1. Accessed 8 Aug 2016

  9. World Health Organization (2012) Potassium intake for adults and children—guideline. World Health Organization. http://apps.who.int/iris/bitstream/10665/77986/1/9789241504829_eng.pdf?ua=1. Accessed 16 Feb 2018

  10. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J (2006) Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 114(1):82–96. https://doi.org/10.1161/CIRCULATIONAHA.106.176158

    Article  PubMed  Google Scholar 

  11. World Health Organization (2013) NCD global monitoring framework. World Health Organization,. http://www.who.int/nmh/global_monitoring_framework/en/. Accessed 16 Nov 2015

  12. Intersalt Cooperative Research Group (1988) Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24-hour urinary sodium and potassium excretion. BMJ 297(6644):319–328

    Article  Google Scholar 

  13. Zhou BF, Stamler J, Dennis B, Moag-Stahlberg A, Okuda N, Robertson C, Zhao L, Chan Q, Elliott P (2003) Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study. J Hum Hypertens 17(9):623–630. https://doi.org/10.1038/sj.jhh.1001605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Powles J, Fahimi S, Micha R, Khatibzadeh S, Shi P, Ezzati M, Engell RE, Lim SS, Danaei G, Mozaffarian D (2013) Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide. BMJ Open 3(12):e003733. https://doi.org/10.1136/bmjopen-2013-003733

    Article  PubMed  PubMed Central  Google Scholar 

  15. Jiang J, Zhang B, Zhang M, Xue F, Tang Y, Liang S, Hou L, Wang W, Han W, Asaiti K, Nasca PC, Wang Y, Pang H, Wang Z, Wang Y, Qiu C (2015) Prevalence of conventional cardiovascular disease risk factors among Chinese Kazakh individuals of diverse occupational backgrounds in Xinjiang China. Int J Cardiol 179:558–560. https://doi.org/10.1016/j.ijcard.2014.10.077

    Article  PubMed  Google Scholar 

  16. Han W, Hu Y, Tang Y, Xue F, Hou L, Liang S, Zhang B, Wang W, Asaiti K, Pang H, Wang Z, Wang Y, Zhang M, Jiang J (2017) Relationship between urinary sodium with blood pressure and hypertension among a Kazakh community population in Xinjiang, China. J Hum Hypertens 31(5):333–340. https://doi.org/10.1038/jhh.2016.83

    Article  CAS  PubMed  Google Scholar 

  17. Liu L, Liu L, Ding Y, Huang Z, He B, Sun S, Zhao G, Zhang H, Miki T, Mizushima S, Ikeda K, Nara Y, Yamori Y (2001) Ethnic and environmental differences in various markers of dietary intake and blood pressure among Chinese Han and three other minority peoples of China: results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study. Hypertens Res 24(3):315–322

    Article  CAS  Google Scholar 

  18. The World Health Organization (2014) STEPwise approach to surveillance (STEPS). The World Health Organization. http://www.who.int/chp/steps/en/. Accessed 23 Sept 2014

  19. World Health Organization (2011) Strategies to monitor and evaluate population sodium consumption and sources of sodium in the diet- report of a joint technical meeting. World Health Organization. http://whqlibdoc.who.int/publications/2011/9789241501699_eng.pdf. Accessed 30 Oct 2014

  20. McLean RM (2014) Measuring population sodium intake: a review of methods. Nutrients 6(11):4651–4662

    Article  Google Scholar 

  21. WHO/PAHO Regional Expert Group for Cardiovascular Disease Prevention through Population-wide Dietary Salt Reduction (2013) Protocol for population level sodium determination in 24-hour urine samples. The World Health Organization and Pan American Health Organization. https://www.paho.org/hq/dmdocuments/2013/24h-urine-Protocol-eng.pdf. Accessed 14 Aug 2017

  22. John KA, Cogswell ME, Campbell NR, Nowson CA, Legetic B, Hennis AJ, Patel SM (2016) Accuracy and usefulness of select methods for assessing complete collection of 24-Hour Urine: A Systematic Review. J Clin Hypertens (Greenwich) 18(5):456–467. https://doi.org/10.1111/jch.12763

    Article  CAS  Google Scholar 

  23. Elliott P, Brown I (2007) Sodium intakes around the world—background document prepared for the Forum and Technical meeting on Reducing Salt Intake in Populations. World Health Organization, Geneva

    Google Scholar 

  24. Joossens JV GJ (1984) Monitoring salt intake of the population: methodological considerations. In: de Backer HvGG PH, Ducimetière P (eds) Surveillance of the dietary habits of the population with regard to cardiovascular diseases. EURO Nut Report 2. pp 61–73. https://doi.org/10.1002/food.19840281012

  25. Hu Y, Wang Z, Wang Y, Wang L, Han W, Tang Y, Xue F, Hou L, Liang S, Zhang B, Wang W, Asaiti K, Pang H, Zhang M, Jiang J (2017) Prevalence, awareness, treatment, and control of hypertension among Kazakhs with high salt intake in Xinjiang, China: a community-based cross-sectional study. Sci Rep 7:45547. https://doi.org/10.1038/srep45547

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. WHO Regional office for Europe (2019) FEEDcities project—the food environment in cities in eastern Europe and Central Asia—Kazakhstan. World Health Organization. http://www.euro.who.int/__data/assets/pdf_file/0006/396591/WHO-FEED-Kazakhstan-report_v6.pdf?ua=1. Accessed 22 Mar 2019

  27. Ministry of National Economy of the Republic of Kazakhstan Committee on Statistics (2019) Standard of living of population. Ministry of National Economy of the Republic of Kazakhstan. http://stat.gov.kz/faces/wcnav_externalId/homeNumbersLivingStandart;jsessionid = xSvXJ_3Q9i56UgBx8n_P3XX7v-wtA9jqQxeGQjrWRqfy2GP_oeD9!1297609147!313338418?_adf.ctrl-state=7aj9u7q3j_4&_afrLoop=5319340933202703#%40%3F_afrLoop%3D5319340933202703%26_adf.ctrl-state%3Dbkw4bm0r5_4. Accessed 1 Apr 2018

  28. Brown IJ, Tzoulaki I, Candeias V, Elliott P (2009) Salt intakes around the world: implications for public health. Int J Epidemiol 38(3):791–813. https://doi.org/10.1093/ije/dyp139

    Article  PubMed  Google Scholar 

  29. Johnson C, Mohan S, Rogers K, Shivashankar R, Thout SR, Gupta P, He FJ, MacGregor GA, Webster J, Krishnan A, Maulik PK, Reddy KS, Prabhakaran D, Neal B (2017) Mean dietary salt intake in urban and rural areas in India: a population survey of 1395 persons. J Am Heart Assoc 6(1):e004547. https://doi.org/10.1161/JAHA.116.004547

    Article  PubMed  PubMed Central  Google Scholar 

  30. McLean R, Edmonds J, Williams S, Mann J, Skeaff S (2015) Balancing sodium and potassium: estimates of intake in a New Zealand adult population sample. Nutrients 7(11):8930–8938. https://doi.org/10.3390/nu7115439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Cogswell ME, Loria CM, Terry AL, Zhao L, Wang CY, Chen TC, Wright JD, Pfeiffer CM, Merritt R, Moy CS, Appel LJ (2018) Estimated 24-hour urinary sodium and potassium excretion in US adults. JAMA 319(12):1209–1220. https://doi.org/10.1001/jama.2018.1156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Na Tasevska, Runswick SA, Bingham SA (2006) Urinary potassium is as reliable as urinary nitrogen for use as a recovery biomarker in dietary studies of free living individuals. J Nutr 136(5):1334–1340. https://doi.org/10.1093/jn/136.5.1334%

    Article  Google Scholar 

  33. Stamler J, Elliott P, Chan Q (2003) INTERMAP appendix tables, tables of contents (tables A). J Hum Hypertens 17(9):665

    Article  Google Scholar 

  34. Hall JN, Moore S, Harper SB, Lynch JW (2009) Global variability in fruit and vegetable consumption. Am J Prev Med 36(5):402.e405–409.e405. https://doi.org/10.1016/j.amepre.2009.01.029

    Article  Google Scholar 

  35. Perez V, Chang ET (2014) Sodium-to-potassium ratio and blood pressure, hypertension, and related factors. Adv Nutr 5(6):712–741. https://doi.org/10.3945/an.114.006783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. van Mierlo LA, Greyling A, Zock PL, Kok FJ, Geleijnse JM (2010) Suboptimal potassium intake and potential impact on population blood pressure. Arch Intern Med 170(16):1501–1502. https://doi.org/10.1001/archinternmed.2010.284

    Article  PubMed  Google Scholar 

  37. Webb M, Fahimi S, Singh GM, Khatibzadeh S, Micha R, Powles J, Mozaffarian D (2017) Cost effectiveness of a government supported policy strategy to decrease sodium intake: global analysis across 183 nations. BMJ. https://doi.org/10.1136/bmj.i6699

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors wish to thank Oksana Dolmatova, Arailym Beisbekova and Marzhan Adlet for participation in for data collection and field work, and the participants for their support and interest in partaking in the survey.

Funding

KT is supported by an Early Career Fellowship (APP1161597) from the National Health and Medical Research Council of Australia (NHMRC) and a Postdoctoral Fellowship (Award ID 102140) from the National Heart Foundation of Australia. FO and ST were supported by Kazakh Academy of Nutrition from the grant of the Ministry of Education and Science, Republic of Kazakhstan. JAS is supported by the NHMRC Postgraduate Scholarship (#1168948). JW is supported by a National Heart Foundation Future Leaders Fellowship (#102039). KT, JAS and JW are part of the NHMRC Center for Research Excellence on food policy interventions to reduce salt (#1117300).

Author information

Authors and Affiliations

Authors

Contributions

FO and ST designed and conducted the research; JJ and JB provided essential materials; KT and JAS analysed the data, KT and JW wrote the paper; KT had primary responsibility for final content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kathy Trieu.

Ethics declarations

Conflicts of interest

JW is Director of the WHO Collaborating Centre on Population Salt Reduction. The co-authors Jo Jewell and Joao Breda were staff members of the WHO Regional Office for Europe at the time of the study. The authors are responsible for the views expressed in this publication and they do not necessarily represent the decisions or stated policy of WHO. All other authors declare that they have no other competing interests related to this review.

Ethics approval

The project received ethical approval by the Kazakh Academy of Nutrition Ethics Committee (Project #2524/ГФ4).

Informed consent

Each participant was briefed on the project and provided written informed consent.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 22 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Trieu, K., Ospanova, F., Tazhibayev, S. et al. Sodium and potassium intakes in the Kazakhstan population estimated using 24-h urinary excretion: evidence for national action. Eur J Nutr 60, 1537–1546 (2021). https://doi.org/10.1007/s00394-020-02354-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00394-020-02354-6

Keywords

Navigation