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The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function

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European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Objective

Peripheral endothelial dysfunction (PED) is associated with major adverse cardiovascular events. Similar to cardio-protective Mediterranean diet, Chardonnay seeds are rich in polyphenols, fibers, and grape seed oil. In this randomized double-blinded trial, we investigated safety and incremental benefit of Chardonnay seed polyphenols-rich (PR), compared to polyphenols-free (PF), supplements on PED.

Methods

89 patients with PED [reactive hyperemia-peripheral arterial tonometry (RH-PAT) index ≤ 2) were randomized 1:1 to 4.8 g (6 capsules)/day PR or PF for 4 months. PR and PF capsules had equal amounts of seed oil (~ 7% capsule weight), fibers, and carbohydrates, but only PR capsules contained polyphenols (~ 11% capsule weight). Baseline and follow-up RH-PAT indices (primary endpoint) and endothelial progenitor cells (EPC) levels were measured. Patients were asked to maintain their regular diet and exercise habits during study period.

Results

Baseline RH-PAT indices, demographics, lab values, and EPC levels were similar between groups. No significant adverse reactions to PR or PF were reported. Follow-up RH-PAT indices significantly increased (p < 0.05 vs. baseline) in both groups to similar extent (31 ± 39% PR vs. 49 ± 53% PF, p = 0.09). Circulating CD34 + EPCs equally increased (median + 55% vs. + 54%, p = 0.94) in PR and PF groups, respectively.

Conclusion

PR and PF Chardonnay seed supplements were safe and improved peripheral endothelial function to similar extent in PED patients. However, there were no incremental benefits of PR over PF on RH-PAT indices or CD34 + EPC levels. Chardonnay seed supplements role in primary prevention of atherosclerosis, as add-on to healthy lifestyle and guidelines directed medical therapy, should be further explored.

ClinicalTrials.gov identifier (NCT number)

NCT02093455

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Abbreviations

EndoPAT:

Endothelial-peripheral arterial tonometry

EPC:

Endothelial progenitor cells

PED:

Peripheral endothelial dysfunction

PR:

Polyphenol-rich

PF:

Polyphenol-free

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Funding

Unrestricted grant from Sonomaceuticals, LLC, dba Whole-Vine Products (Santa Rosa, CA).

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Authors and Affiliations

  1. Department of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA

    Michel T. Corban, Robert Jay Widmer, Rebecca Cilluffo, Makinzee A. Kazeck, Lilach O. Lerman & Amir Lerman

  2. Department of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA

    Ryan J. Lennon

  3. Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA

    Lilach O. Lerman

Authors
  1. Michel T. Corban
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Contributions

Each of the authors contributed significantly to this manuscript. MTC, RJW, RC, AL, and MAK were involved in the inception and conduction of the trial. RJL performed the statistical analysis. MTC and AL wrote the paper. RJW, RC, and LOL revised the manuscript for important intellectual content. AL was critically involved throughout the conduction of the trial and preparation of the paper, and had primary responsibility of final content.

Corresponding author

Correspondence to Amir Lerman.

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Conflict of interest

All authors have no conflict of interest related to this study.

Ethical standards

The trial was approved by Mayo Clinic Institutional Review Board and was conducted in accordance to the ethical standards of Helsinki Declaration. All patients provided written informed consent.

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Corban, M.T., Widmer, R.J., Cilluffo, R. et al. The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function. Eur J Nutr 59, 3723–3734 (2020). https://doi.org/10.1007/s00394-020-02203-6

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  • DOI: https://doi.org/10.1007/s00394-020-02203-6

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