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Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study

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Abstract

Purpose

The effects of seaweed compounds have been studied in relation to colorectal cancer (CRC) based on their ability to modulate carcinogen metabolism in vivo and in vitro. However, no epidemiological studies on the interaction between edible seaweed and genetic variants relevant to CRC have been reported. This study examined the associations among dietary seaweed intake (gim, miyeok, and dashima), single-nucleotide polymorphisms (SNPs; rs6983267, rs7014346, and rs719725), and CRC risk in a Korean population.

Methods

The participants comprised 923 CRC patients and 1846 controls who visited the National Cancer Center Korea. We used a Semiquantitative Food Frequency Questionnaire and genotyped SNPs using genomic DNA samples.

Results

The intake of total seaweed, miyeok, and dashima showed a significant inverse association with CRC risk after adjusting for potential confounding factors (total seaweed odds ratio (OR) [95% CI] = 0.65 [0.50–0.85], P for trend < 0.001; miyeok = 0.82 [0.62–1.09], P for trend < 0.05; dashima = 0.58 [0.44–0.76], P for trend < 0.001, highest vs. lowest tertile). We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34–0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25–0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake).

Conclusions

This study provides evidence of the effect of dietary seaweed intake on CRC risk with respect to c-MYC gene variants.

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Abbreviations

BMI:

Body mass index

CI:

Confidence interval

CRC:

Colorectal cancer

GWAS:

Genome-wide association study

HWE:

Hardy–Weinberg equilibrium

OR:

Odds ratio

SNP:

Single-nucleotide polymorphism

SQFFQ:

Semiquantitative Food Frequency Questionnaire

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Acknowledgements

We are thankful to all participants involved in this study. This research was supported by grants from the National Cancer Center in Korea (1710882, 1810090).

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Authors and Affiliations

  1. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, South Korea

    Jimi Kim, Jeonghee Lee & Jeongseon Kim

  2. Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, South Korea

    Jae Hwan Oh, Hee Jin Chang & Dae Kyung Sohn

  3. Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea

    Aesun Shin

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  1. Jimi Kim
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Contributions

The authors’ responsibilities were as follows: JMK and JSK designed the research, performed the statistical analysis, and had primary responsibility for the final content; JL, JHO, HJC, DKS, and AS recruited the study participants, collected the data, and conducted the research; JMK and JSK wrote the manuscript; and all authors read and approved the final manuscript.

Corresponding author

Correspondence to Jeongseon Kim.

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Conflict of interest

The authors (Jimi Kim, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, and Jeongseon Kim) declare that they have no conflicts of interest.

Ethical standards

Written and signed informed consent was obtained from all patients in adherence to the National Cancer Center Korea guidelines. This study was approved by the Institutional Review Board of the National Cancer Center Korea (IRB no. NCCNCS-10-350 and no. NCC2015-0202).

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Kim, J., Lee, J., Oh, J.H. et al. Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study. Eur J Nutr 59, 1963–1974 (2020). https://doi.org/10.1007/s00394-019-02046-w

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