Beneficial effects of ginger on prevention of obesity through modulation of gut microbiota in mice
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Recent evidence has demonstrated that the gut microbiota plays a critical role in the treatment of obesity and other metabolic dysfunctions. Ginger (Zingiber officinale Roscoe), one of the most commonly used spices and dietary supplements, has been shown to exert beneficial effects against obesity and related disorders. However, to date, the mechanisms linking these effects to the gut microbiota remain unclear. This study aims to investigate the relationship between the gut microbiota and the metabolic adaptations resulting from ginger supplementation in mice.
Four groups of mice were fed a normal chow diet (NCD) or a high-fat diet (HFD) with or without ginger supplementation for 16 weeks. Lipid profiles, proinflammatory cytokines, glucose tolerance, microbiota composition and short-chain fatty acid (SCFA) concentrations were analyzed at the end of the experiment. In addition, microbiota-depleted mice were transplanted with the fecal microbiota of mice fed a HFD or mice fed a HFD along with ginger supplementation. Glucose tolerance and microbiota composition were assessed after a 8-week fecal microbiota transplantation (FMT).
We observed marked decreases in body weight, liver steatosis, and low-grade inflammation as well as amelioration of insulin resistance in the HFD-fed mice treated with ginger. Furthermore, ginger supplementation modulated the gut microbiota composition and increased species belonging to the Bifidobacterium genus and SCFA-producing bacteria (Alloprevotella and Allobaculum), along with increases in fecal SCFA concentrations. The FMT experiment showed anti-obesity and microbiota-modulating effects similar to those observed in the oral ginger-feeding experiment.
This study suggests that modulation of the gut microbiota as a result of ginger supplementation has a therapeutic effect on obesity in mice.
KeywordsGinger Gut microbiota Obesity Short-chain fatty acid Fecal microbiota transplantation
This work was supported by the Beijing Municipal Science and Technology Project (Grant number D16110500540001).
Compliance with ethical standards
Conflict of interest
The authors declare no competing interests.
- 1.World Health Organization (2018) Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 13 Mar 2018
- 11.Bartley JP, Jacobs AL (2000) Effects of drying on flavour compounds in Australian-grown ginger (Zingiber officinale). J Sci Food Agric 80(2):209–215. https://doi.org/10.1002/(SICI)1097-0010(20000115)80:2%3C209::AID-JSFA516%3E3.0.CO;2-8 CrossRefGoogle Scholar
- 18.Sani NFA, Belani LK, Chong PS et al (2014) Effect of the combination of gelam honey and ginger on oxidative stress and metabolic profile in streptozotocin-induced diabetic sprague-dawley rats. Biomed Res Int 2014(4):160695. https://doi.org/10.1155/2014/160695 CrossRefPubMedPubMedCentralGoogle Scholar
- 19.Akinyemi AJ, Thome GR, Morsch VM et al (2015) Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats. J Appl Biomed 14(1):59–70. https://doi.org/10.1016/j.jab.2015.06.001 CrossRefGoogle Scholar
- 20.Gao H, Guan T, Li C et al (2012) Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: modulation of the hepatic carbohydrate response element-binding protein-mediated pathway. Evid Based Complement Altern Med 2012:570948. https://doi.org/10.1155/2012/570948 CrossRefGoogle Scholar
- 33.Nammi S, Sreemantula S, Roufogalis BD (2010) Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic Clin Pharmacol Toxicol 104(5):366–373. https://doi.org/10.1111/j.1742-7843.2008.00362.x CrossRefGoogle Scholar
- 34.Brahmanaidu P, Uddandrao VV, Ravindarnaik RC et al (2015) Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats. Mol Cell Endocrinol 419(5):139–147. https://doi.org/10.1016/j.mce.2015.10.007 CrossRefGoogle Scholar