Skip to main content

Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

European Journal of Nutrition volume 58, pages 3303–3312 (2019)Cite this article

Abstract

Purpose

Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study.

Methods

The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires.

Results

During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases.

Conclusions

In this large prospective study, coffee and tea consumptions were not associated with TC risk.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price includes VAT (USA)
Tax calculation will be finalised during checkout.

Data Availability

For information on how to submit an application for gaining access to EPIC data and/or biospecimens, please follow the instructions at http://epic.iarc.fr/access/index.php.

Abbreviations

24-HDR:

24-h dietary recall

BMI:

Body mass index

CI:

Confidence interval

EPIC:

European Prospective Investigation into Cancer and Nutrition

HR:

Hazard ratio

IARC:

International Agency for Research on Cancer

NOS:

Not otherwise specified

TC:

Thyroid cancer

References

  1. Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013:965212. https://doi.org/10.1155/2013/965212

    Article  PubMed  PubMed Central  Google Scholar 

  2. Vaccarella S, Franceschi S, Bray F, Wild CP, Plummer M, Dal Maso L (2016) Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med 375:614–617. https://doi.org/10.1056/NEJMp1604412

    Article  Google Scholar 

  3. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386. https://doi.org/10.1002/ijc.29210

    CAS  Article  PubMed  Google Scholar 

  4. Dal Maso L, Bosetti C, La Vecchia C, Franceschi S (2009) Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors. Cancer Causes Control 20:75–86. https://doi.org/10.1007/s10552-008-9219-5

    Article  PubMed  Google Scholar 

  5. Kitahara CM, McCullough ML, Franceschi S, Rinaldi S, Wolk A, Neta G, Olov Adami H, Anderson K, Andreotti G, Beane Freeman LE, Bernstein L, Buring JE, Clavel-Chapelon F, De Roo LA, Gao YT, Gaziano JM, Giles GG, Håkansson N, Horn-Ross PL, Kirsh VA, Linet MS, MacInnis RJ, Orsini N, Park Y, Patel AV, Purdue MP, Riboli E, Robien K, Rohan T, Sandler DP, Schairer C, Schneider AB, Sesso HD, Shu XO, Singh PN, van den Brandt PA, Ward E, Weiderpass E, White E, Xiang YB, Zeleniuch-Jacquotte A, Zheng W, Hartge P, Berrington de González A (2016) Anthropometric factors and thyroid cancer risk by histological subtype: pooled analysis of 22 prospective studies. Thyroid 26:306–318. https://doi.org/10.1089/thy.2015.0319

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sen A, Tsilidis KK, Allen NE, Rinaldi S, Appleby PN, Almquist M, Schmidt JA, Dahm CC, Overvad K, Tjønneland A, Rostgaard-Hansen AL, Clavel-Chapelon F, Baglietto L, Boutron-Ruault MC, Kühn T, Katze VA, Boeing H, Trichopoulou A, Tsironis C, Lagiou P, Palli D, Pala V, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HA, Peeters PH, Hjartåker A, Lund E, Weiderpass E, Quirós JR, Agudo A, Sánchez MJ, Arriola L, Gavrila D, Gurrea AB, Tosovic A, Hennings J, Sandström M, Romieu I, Ferrari P, Zamora-Ros R, Khaw KT, Wareham NJ, Riboli E, Gunter M, Franceschi S (2015) Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. Br J Cancer 113:840–847. https://doi.org/10.1038/bjc.2017.235

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Zamora-Ros R, Rinaldi S, Tsilidis KK, Weiderpass E, Boutron-Ruault MC, Rostgaard-Hansen AL, Tjønneland A, Clavel-Chapelon F, Mesrine S, Katzke VA, Kühn T, Förster J, Boeing H, Trichopoulou A, Lagiou P, Klinaki E, Masala G, Sieri S, Ricceri F, Tumino R, Mattiello A, Peeters PH, Bueno-de-Mesquita HB, Engeset D, Skeie G, Argüelles M, Agudo A, Sánchez MJ, Chirlaque MD, Barricarte A, Chamosa S, Almquist M, Tosovic A, Hennings J, Sandström M, Schmidt JA, Khaw KT, Wareham NJ, Cross AJ, Slimani N, Byrnes G, Romieu I, Riboli E, Franceschi S (2016) Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer 138:65–73. https://doi.org/10.1002/ijc.29693

    CAS  Article  PubMed  Google Scholar 

  8. Xiao Q, Park Y, Hollenbeck AR, Kitahara CM (2014) Dietary flavonoid intake and thyroid cancer risk in the NIH-AARP diet and health study. Cancer Epidemiol Biomark Prev 23:1102–1108. https://doi.org/10.1158/1055-9965.EPI-13-1150

    CAS  Article  Google Scholar 

  9. Zamora-Ros R, Beraud V, Franceschi S, Cayssials V, Tsilidis KK, Boutron-Ruault MC, Weiderpass E, Overvad K, Tjønneland A, Eriksen AK, Bonnet F, Affret A, Katzke V, Kühn T, Boeing H, Trichopoulou A, Valanou E, Karakatsani A, Masala G, Grioni S, Santucci de Magistris M, Tumino R, Ricceri F, Skeie G, Parr CL, Merino S, Salamanca-Fernández E, Chirlaque MD, Ardanaz E, Amiano P, Almquist M, Drake I, Hennings J, Sandström M, Bueno-de-Mesquita HBA, Peeters PH, Khaw KT, Wareham NJ, Schmidt JA, Perez-Cornago A, Aune D, Riboli E, Slimani N, Scalbert A, Romieu I, Agudo A, Rinaldi S (2018) Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Cancer 142:449–459. https://doi.org/10.1002/ijc.30880

    CAS  Article  PubMed  Google Scholar 

  10. Zamora-Ros R, Castaneda J, Rinaldi S, Cayssials V, Slimani N, Weiderpass E, Tsilidis KK, Boutron-Ruault MC, Overvad K, Eriksen AK, Tjønneland A, Kühn T, Katzke V, Boeing H, Trichopoulou A, La Vecchia C, Kotanidou A, Palli D, Grioni S, Mattiello A, Tumino R, Sciannameo V, Lund E, Merino S, Salamanca-Fernández E, Amiano P, Huerta JM, Barricarte A, Ericson U, Almquist M, Hennings J, Sandström M, Bueno-de-Mesquita HB, Peeters PH, Khaw KT, Wareham NJ, Schmidt JA, Cross AJ, Riboli E, Scalbert A, Romieu I, Agudo A, Franceschi S (2017) Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Nutr 147:1366–1373. https://doi.org/10.3945/jn.117.247874

    CAS  Article  PubMed  Google Scholar 

  11. Ma S, Wang C, Bai J, Wang X, Li C (2015) Association of tea consumption and the risk of thyroid cancer: a meta-analysis. Int J Clin Exp Med 8:14345–14351

    PubMed  PubMed Central  Google Scholar 

  12. Han MA, Kim JH (2017) Coffee consumption and the risk of thyroid cancer: a systematic review and meta-analysis. Int J Environ Res Public Health 14:E129. https://doi.org/10.3390/ijerph14020129

    CAS  Article  PubMed  Google Scholar 

  13. Di Lorenzo A, Curti V, Tenore GC, Nabavi SM, Daglia M (2017) Effects of tea and coffee consumption on cardiovascular diseases and relative risk factors: an update. Curr Pharm Des 23:2474–2487. https://doi.org/10.2174/1381612823666170215145855

    CAS  Article  PubMed  Google Scholar 

  14. Zamora-Ros R, Knaze V, Rothwell JA, Hémon B, Moskal A, Overvad K, Tjønneland A, Kyrø C, Fagherazzi G, Boutron-Ruault MC, Touillaud M, Katzke V, Kühn T, Boeing H, Förster J, Trichopoulou A, Valanou E, Peppa E, Palli D, Agnoli C, Ricceri F, Tumino R, de Magistris MS, Peeters PH, Bueno-de-Mesquita HB, Engeset D, Skeie G, Hjartåker A, Menéndez V, Agudo A, Molina-Montes E, Huerta JM, Barricarte A, Amiano P, Sonestedt E, Nilsson LM, Landberg R, Key TJ, Khaw KT, Wareham NJ, Lu Y, Slimani N, Romieu I, Riboli E, Scalbert A (2016) Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr 55:1359–1375. https://doi.org/10.1007/s00394-015-0950-x

    CAS  Article  PubMed  Google Scholar 

  15. Gonçalves CFL, de Freitas ML, Ferreira ACF (2017) Flavonoids, thyroid iodide uptake and thyroid cancer—a review. Int J Mol Sci 18:E1247. https://doi.org/10.3390/ijms18061247

    CAS  Article  PubMed  Google Scholar 

  16. Clere N, Faure S, Martinez MC, Andriantsitohaina R (2011) Anticancer properties of flavonoids: roles in various stages of carcinogenesis. Cardiovasc Hematol Agents Med Chem 9:62–77

    CAS  Article  Google Scholar 

  17. Ramos S (2008) Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52:507–526. https://doi.org/10.1002/mnfr.200700326

    CAS  Article  PubMed  Google Scholar 

  18. Sabisz M, Skladanowski A (2008) Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more. Curr Pharm Biotechnol 9:325–336

    CAS  Article  Google Scholar 

  19. Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K, Tjønneland A, Clavel-Chapelon F, Thiébaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, González CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5:1113–1124

    CAS  Article  Google Scholar 

  20. Margetts BM, Pietinen P (1997) European Prospective Investigation into Cancer and Nutrition: validity studies on dietary assessment methods. Int J Epidemiol 26(Suppl 1):S1–S5

    Article  Google Scholar 

  21. Slimani N, Kaaks R, Ferrari P, Casagrande C, Clavel-Chapelon F, Lotze G, Kroke A, Trichopoulos D, Trichopoulou A, Lauria C, Bellegotti M, Ocké MC, Peeters PH, Engeset D, Lund E, Agudo A, Larrañaga N, Mattisson I, Andren C, Johansson I, Davey G, Welch AA, Overvad K, Tjønneland A, Van Staveren WA, Saracci R, Riboli E (2002) European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics. Public Health Nutr 5:1125–1145

    CAS  Article  Google Scholar 

  22. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE (2003) Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 6:407–413

    Article  Google Scholar 

  23. Wang M, Spiegelman D, Kuchiba A, Lochhead P, Kim S, Chan AT, Poole EM, Tamimi R, Tworoger SS, Giovannucci E, Rosner B, Ogino S (2016) Statistical methods for studying disease subtype heterogeneity. Stat Med 35(5):782–800. https://doi.org/10.1002/sim.6793

    Article  PubMed  Google Scholar 

  24. Ferrari P, Kaaks R, Fahey MT, Slimani N, Day NE, Pera G, Boshuizen HC, Roddam A, Boeing H, Nagel G, Thiebaut A, Orfanos P, Krogh V, Braaten T, Riboli E, European Prospective Investigation into Cancer and Nutrition study (2004) Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition study. Am J Epidemiol 160:814–822

    Article  Google Scholar 

  25. Hashibe M, Galeone C, Buys SS, Gren L, Boffetta P, Zhang ZF, La Vecchia C (2015) Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort. Br J Cancer 113:809–816. https://doi.org/10.1038/bjc.2015.276

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  26. Michikawa T, Inoue M, Shimazu T, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S (2011) Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan. Cancer Causes Control 22:985–993. https://doi.org/10.1007/s10552-011-9771-2

    Article  PubMed  Google Scholar 

  27. Frentzel-Beyme R, Helmert U (2000) Association between malignant tumors of the thyroid gland and exposure to environmental protective and risk factors. Rev Environ Health 15:337–358

    CAS  Article  Google Scholar 

  28. Edmands WM, Ferrari P, Rothwell JA, Rinaldi S, Slimani N, Barupal DK, Biessy C, Jenab M, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC, Katzke VA, Kühn T, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Grioni S, Tumino R, Vineis P, Mattiello A, Romieu I, Scalbert A (2015) Polyphenol metabolome in human urine and its association with intake of polyphenol-rich foods across European countries. Am J Clin Nutr 102:905–913. https://doi.org/10.3945/ajcn.114.101881

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Mr. Bertrand Hémon for his valuable help with the EPIC database. The authors also thank all participants in the EPIC cohorts for their invaluable contribution to the study.

Funding

This study was supported by the Institute of Health Carlos III, Spain (CP15/00100), and cofounded by the European Regional Development Fund (ERDF) “A way to build Europe”. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, AGAUR, Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds (RD12/0036/0018) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). RZ-R would like to thank the “Miguel Servet” program (CP15/00100) from the Institute of Health Carlos III (Spain) and the European Social Fund (ESF).

Author information

Authors and Affiliations

  1. Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Av Gran Via 199-203, 08908, L’Hospitalet de Llobregat, Spain

    Raul Zamora-Ros, Muath A. Alghamdi, Valerie Cayssials & Antonio Agudo

  2. College of Medicine, Al Imam Mohammed Ibn Saud Islamic University, Riyadh, Saudi Arabia

    Muath A. Alghamdi

  3. Epidemiology Unit, Aviano Cancer Center, Milan, Italy

    Silvia Franceschi

  4. Department of Surgery, Skåne University Hospital Malmö, Lund University, Lund, Sweden

    Martin Almquist & Jonas Manjer

  5. Malmö Diet and Cancer Study, University Hospital Malmö, Malmö, Sweden

    Martin Almquist

  6. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden

    Joakim Hennings

  7. Department for Radiation Sciences, Umeå University, Umeå, Sweden

    Maria Sandström

  8. Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

    Konstantinos K. Tsilidis

  9. School of Public Health, Imperial College London, London, UK

    Konstantinos K. Tsilidis, H. Bas Bueno-de-Mesquita & Dagfinn Aune

  10. Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Tromsø, Tromsö, Norway

    Elisabete Weiderpass, Guri Skeie & Tonje Braaten

  11. Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway

    Elisabete Weiderpass

  12. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Elisabete Weiderpass

  13. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland

    Elisabete Weiderpass

  14. CESP, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France

    Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh & Fabrice Bonnet

  15. Institut Gustave Roussy, Villejuif, France

    Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh & Fabrice Bonnet

  16. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

    Bodil Hammer Bech & Kim Overvad

  17. Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark

    Anne Tjønneland & Kristina E. N. Petersen

  18. CHU Rennes, Université de Rennes 1, Rennes, France

    Fabrice Bonnet

  19. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

    Tilman Kühn & Renée T. Fortner

  20. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

    Heiner Boeing

  21. Hellenic Health Foundation, Athens, Greece

    Antonia Trichopoulou, Christina Bamia & Georgia Martimianaki

  22. Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Antonia Trichopoulou & Christina Bamia

  23. Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy

    Giovanna Masala

  24. Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Sara Grioni

  25. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

    Salvatore Panico

  26. Cancer Registry and Histopathology Unit, “Civic M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy

    Rosario Tumino

  27. Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Turin, Italy

    Francesca Fasanelli

  28. Department of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain

    Cristina Lasheras

  29. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain

    Elena Salamanca-Fernández

  30. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

    Elena Salamanca-Fernández, Pilar Amiano, Maria-Dolores Chirlaque & Aurelio Barricarte

  31. Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia, Spain

    Pilar Amiano

  32. Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain

    Maria-Dolores Chirlaque

  33. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain

    Maria-Dolores Chirlaque

  34. Navarra Public Health Institute, Pamplona, Spain

    Aurelio Barricarte

  35. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain

    Aurelio Barricarte

  36. Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden

    Peter Wallström

  37. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

    H. Bas Bueno-de-Mesquita

  38. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands

    H. Bas Bueno-de-Mesquita

  39. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    H. Bas Bueno-de-Mesquita

  40. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Petra H. Peeters

  41. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

    Kay-Thee Khaw

  42. MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK

    Nicholas J. Wareham

  43. Cancer Epidemiology Unit, University of Oxford, Oxford, UK

    Julie A. Schmidt

  44. International Agency for Research on Cancer (IARC), Lyon, France

    Graham Byrnes, Augustin Scalbert & Sabina Rinaldi

Authors
  1. Raul Zamora-Ros
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Muath A. Alghamdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Valerie Cayssials
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Silvia Franceschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Martin Almquist
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Joakim Hennings
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maria Sandström
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Konstantinos K. Tsilidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Elisabete Weiderpass
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Marie-Christine Boutron-Ruault
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Bodil Hammer Bech
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Kim Overvad
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Anne Tjønneland
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Kristina E. N. Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Francesca Romana Mancini
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Yahya Mahamat-Saleh
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Fabrice Bonnet
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Tilman Kühn
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Renée T. Fortner
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Heiner Boeing
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Antonia Trichopoulou
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Christina Bamia
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Georgia Martimianaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Giovanna Masala
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Sara Grioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Salvatore Panico
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Rosario Tumino
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Francesca Fasanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Guri Skeie
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Tonje Braaten
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Cristina Lasheras
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Elena Salamanca-Fernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Pilar Amiano
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Maria-Dolores Chirlaque
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Aurelio Barricarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Jonas Manjer
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. Peter Wallström
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. H. Bas Bueno-de-Mesquita
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. Petra H. Peeters
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. Kay-Thee Khaw
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. Nicholas J. Wareham
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. Julie A. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. Dagfinn Aune
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. Graham Byrnes
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. Augustin Scalbert
    View author publications

    You can also search for this author in PubMed Google Scholar

  46. Antonio Agudo
    View author publications

    You can also search for this author in PubMed Google Scholar

  47. Sabina Rinaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

RZ-R, SF, and SR designed the research; RZ-R, MAA, and VC performed the statistical analyses; RZ-R and MAA drafted the manuscript; SF, MA, JH, MS, KKT, EW, M-CB-R, GB, AS, AA, and SR contributed to the discussion. All authors reviewed, edited, and approved the final manuscript.

Corresponding author

Correspondence to Raul Zamora-Ros.

Ethics declarations

Conflict of interest

Zamora-Ros R, Alghamdi MA, Cayssials V, Franceschi S, Almquist M, Hennings J, Sandström M, Tsilidis KK, Weiderpass E, Boutron-Ruault M-C, Hammer Bech B, Overvad K, Tjønneland A, Petersen KEN, Mancini FR, Mahamat-Saleh Y, Bonnet F, Kühn T, Fortner RT, Boeing H, Trichopoulou A, Bamia C, Martimianaki G, Masala G, Grioni S, Panico S, Tumino R, Fasanelli F, Skeie G, Braaten T, Lasheras C, Salamanca-Fernández E, Amiano P, Chirlaque M-D, Barricarte A, Manjer J, Wallström P, Bueno-de-Mesquita HB, Peeters PH, Khaw K-T, Wareham NJ, Schmidt JA, Aune D, Byrnes G, Scalbert A, Agudo A, and Rinaldi S have no conflict of interest.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 21 KB)

Supplementary material 2 (DOCX 18 KB)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zamora-Ros, R., Alghamdi, M.A., Cayssials, V. et al. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr 58, 3303–3312 (2019). https://doi.org/10.1007/s00394-018-1874-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00394-018-1874-z

Keywords

  • Thyroid cancer
  • Coffee
  • Tea
  • Intake
  • Cohort
  • EPIC