Impact of a high-protein diet during lactation on milk composition and offspring in a pig model

Abstract

Purpose

Early postnatal nutrition not only holds relevance to infant growth, but also determines the risk of developing obesity and chronic diseases such as diabetes type 2 and cardiovascular diseases in adulthood. It is suggested that a high-protein (HP) diet in early childhood can predispose children to obesity. However, data concerning possible alterations in milk composition and the development of the offspring in response to a maternal HP diet are currently not available. To address this question, we conducted a study using pigs as a model organism.

Methods

At parturition, sows were assigned to two experimental groups. During lactation, the control group received a diet with a protein content of 16%, whereas the diet of the HP group contained 30% protein. After 28 days of lactation, samples were taken from sows and piglets for the quantification of free amino acids and other metabolites and for histology.

Results

Serum and milk urea showed the most marked differences between the two groups of sows, whereas serum urea concentration in piglets did not differ. Here, we found that the intake of an HP diet changed a series of metabolites in sows, but had only small effects on milk composition and virtually no effects on growth in the offspring. Interestingly, maternal protein intake during lactation shapes the microbiome of the offspring.

Conclusion

From our current study, we conclude that even a very high maternal protein intake throughout lactation has no impact on growth and health parameters of the offspring.

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Abbreviations

BCAA:

Branched chain amino acid

C:

Control

CP:

Crude protein

FAA:

Free amino acid

HP:

High protein

IGF-1:

Insulin-like growth factor 1

LSM:

Least-squares means

PBS:

Phosphate buffered saline

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Correspondence to Alexandra Schutkowski.

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Schutkowski, A., Kluge, H., Trotz, P. et al. Impact of a high-protein diet during lactation on milk composition and offspring in a pig model. Eur J Nutr 58, 3241–3253 (2019). https://doi.org/10.1007/s00394-018-1867-y

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Keywords

  • Lactation
  • Pig
  • High protein
  • Milk