Effect of macronutrient composition on meal-induced thermogenesis in adolescents with obesity

Abstract

Purpose

Manipulation of meal macronutrient may be a useful way to modulate meal-induced thermogenesis (MIT) to induce increases in energy expenditure. The objective of this study was to examine in adolescents with obesity and of healthy weight and the effect of a high protein and high carbohydrate meal on MIT.

Methods

An acute cross-over study with adolescents aged 11–19 years was undertaken. Participants consumed in random order, a high 79% carbohydrate (HCHO), and a high 55% protein (HP) meal (adjusted to 25% of energy requirements). MIT and subjective appetite were assessed for 4 h postprandial and an ad libitum lunch served. Data calculated as total AUC and expressed as mean ± SEM.

Results

Thirteen adolescents with obesity (mean BMI z score 2.3 ± 0.1) and 13 healthy weight (BMI z score 0.0 ± 0.2) participated. Mean MIT (% of energy intake) was greater after the HP (8.19 ± 0.709%) compared with the HCHO meal (4.36 ± 0.480%) (p < 0.001). The HP compared with the HCHO meal promoted greater fullness (12,994 ± 1208 vs 11,186 ± 1220 mm/4 h) (p = 0.016) and decreased hunger (8868 ± 1315 vs 10984 mm ± 1438 mm/4 h) (p = 0.007). These effects observed were independent of body weight.

Conclusions

High protein meals can increase MIT and fullness and reduce hunger compared with high carbohydrate meals in adolescents with obesity. Future research is warranted to determine if MIT can be targeted through manipulation of dietary choices to support weight management strategies.

Trial registration

This study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial ID: ACTRN12612001066875.

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References

  1. 1.

    (2013) Clinical practice guidelines for the management of overweight and obesity in adults, adolescents and children in Australia. Australian Government, National Health and Medical Research Council, Department of Health and Ageing, Canberra, Australia

  2. 2.

    Haby MM, Markwick A, Peeters A, Shaw J, Vos T (2012) Future predictions of body mass index and overweight prevalence in Australia, 2005–2025. Health Promot Int 27:250–260

    Article  PubMed  Google Scholar 

  3. 3.

    Tataranni PA, Larson DE, Snitker S, Ravussin E (1995) Thermic effect of food in humans: methods and results from use of a respiratory chamber. Am J Clin Nutr 61:1013–1019

    Article  CAS  PubMed  Google Scholar 

  4. 4.

    Halton TL, Hu FB (2004) The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 23:373–385

    Article  PubMed  Google Scholar 

  5. 5.

    Quatela A, Callister R, Patterson A, MacDonald-Wicks L (2016) The energy content and composition of meals consumed after an overnight fast and their effects on diet induced thermogenesis: a systematic review, meta-analyses and meta-regressions. Nutrients 8:E670

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Raben A, Agerholm-Larsen L, Flint A, Holst JJ, Astrup A (2003) Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake. Am J Clin Nutr 77:91–100

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Luscombe ND, Clifton PM, Noakes M, Parker B, Wittert G (2002) Effects of energy-restricted diets containing increased protein on weight loss, resting energy expenditure, and the thermic effect of feeding in type 2 diabetes. Diabetes Care 25:652–657

    Article  CAS  PubMed  Google Scholar 

  8. 8.

    Steiniger J, Karst H, Noack R, Steglich HD (1987) Diet-induced thermogenesis in man: thermic effects of single protein and carbohydrate test meals in lean and obese subjects. Ann Nutr Metab 31:117–125

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Marrades MP, Martinez JA, Moreno-Aliaga MJ (2007) Differences in short-term metabolic responses to a lipid load in lean (resistant) vs obese (susceptible) young male subjects with habitual high-fat consumption. Eur J Clin Nutr 61:166–174

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    D’Alessio DA, Kavle EC, Mozzoli MA, Smalley KJ, Polansky M, Kendrick ZV, Owen LR, Bushman MC, Boden G, Owen OE (1988) Thermic effect of food in lean and obese men. J Clin Investig 81:1781–1789

    Article  PubMed  Google Scholar 

  11. 11.

    Segal KR, Edano A, Blando L, Pi-Sunyer FX (1990) Comparison of thermic effects of constant and relative caloric loads in lean and obese men. Am J Clin Nutr 51:14–21

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Tentolouris N, Alexiadou K, Kokkinos A, Koukou E, Perrea D, Kyriaki D, Katsilambros N (2011) Meal-induced thermogenesis and macronutrient oxidation in lean and obese women after consumption of carbohydrate-rich and fat-rich meals. Nutrition 27:310–315

    Article  CAS  PubMed  Google Scholar 

  13. 13.

    Marques-Lopes I, Forga L, Martinez JA (2003) Thermogenesis induced by a high-carbohydrate meal in fasted lean and overweight young men: insulin, body fat, and sympathetic nervous system involvement. Nutrition 19:25–29

    Article  CAS  PubMed  Google Scholar 

  14. 14.

    Maffeis C, Schutz Y, Zoccante L, Pinelli L (1993) Meal-induced thermogenesis in obese children with or without familial history of obesity. Eur J Pediatr 152:128–131

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Maffeis C, Schutz Y, Zoccante L, Micciolo R, Pinelli L (1993) Meal-induced thermogenesis in lean and obese prepubertal children. Am J Clin Nutr 57:481–485

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Katch VL, Moorehead CP, Becque MD, Rocchini AP (1992) Reduced short-term thermic effects of a meal in obese adolescent girls. Eur J Appl Physiol Occup Physiol 65:535–540

    Article  CAS  PubMed  Google Scholar 

  17. 17.

    Maffeis C, Schutz Y, Grezzani A, Provera S, Piacentini G, Tato L (2001) Meal-induced thermogenesis and obesity: is a fat meal a risk factor for fat gain in children? J Clin Endocrinol Metab 86:214–219

    CAS  PubMed  Google Scholar 

  18. 18.

    Nagai N, Sakane N, Hamada T, Kimura T, Moritani T (2005) The effect of a high-carbohydrate meal on postprandial thermogenesis and sympathetic nervous system activity in boys with a recent onset of obesity. Metab Clin Exp 54:430–438

    Article  CAS  PubMed  Google Scholar 

  19. 19.

    Baum JI, Gray M, Binns A (2015) Breakfasts higher in protein increase postprandial energy expenditure, increase fat oxidation, and reduce hunger in overweight children from 8 to 12 years of age. J Nutr 145:2229–2235

    Article  CAS  PubMed  Google Scholar 

  20. 20.

    Portney LGWM (2009) Foundations of clinical research applications to practice, 3rd edn. Pearson Education, New Jersey

    Google Scholar 

  21. 21.

    Flint A, Raben A, Blundell JE, Astrup A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24:38–48

    Article  CAS  PubMed  Google Scholar 

  22. 22.

    (2004) Dietitian’s pocket book. School of Public Health, Department of Nutrition, Dietetics and Food Science, Curtin University of Technology

  23. 23.

    Kowalski KC, Crocker PR, Donen RM (2004) The physical activity questionnaire for older children (PAQ-C) and adolescents (PAQ-A) manual. College of Kinesiology, University of Saskatchewan, Saskatoon, p 87

    Google Scholar 

  24. 24.

    Houtkooper LB, Going SB, Lohman TG, Roche AF, Van Loan M (1992) Bioelectrical impedance estimation of fat-free body mass in children and youth: a cross-validation study. J Appl Physiol (1985) 72:366–373

    Article  CAS  Google Scholar 

  25. 25.

    Haroun D, Croker H, Viner RM, Williams JE, Darch TS, Fewtrell MS, Eaton S, Wells JC (2009) Validation of BIA in obese children and adolescents and re-evaluation in a longitudinal study. Obesity (Silver Spring) 17:2245–2250

    Article  Google Scholar 

  26. 26.

    Weir JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109:1–9

    Article  PubMed  PubMed Central  Google Scholar 

  27. 27.

    Segal KR, Edano A, Tomas MB (1990) Thermic effect of a meal over 3 and 6 hours in lean and obese men. Metab Clin Exp 39:985–992

    Article  CAS  PubMed  Google Scholar 

  28. 28.

    Westerterp-Plantenga MS, Lemmens SG, Westerterp KR (2012) Dietary protein - its role in satiety, energetics, weight loss and health. Br J Nutr 108(Suppl 2):S105–S112

    Article  CAS  PubMed  Google Scholar 

  29. 29.

    Lean ME, Malkova D (2016) Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence? Int J Obes (Lond) 40:622–632

    Article  CAS  Google Scholar 

  30. 30.

    Tounian P, Girardet JP, Carlier L, Frelut ML, Veinberg F, Fontaine JL (1993) Resting energy expenditure and food-induced thermogenesis in obese children. J Pediatr Gastroenterol Nutr 16:451–457

    Article  CAS  PubMed  Google Scholar 

  31. 31.

    Granata GP, Brandon LJ (2002) The thermic effect of food and obesity: discrepant results and methodological variations. Nutr Rev 60:223–233

    Article  PubMed  Google Scholar 

  32. 32.

    Westerterp-Plantenga MS, Rolland V, Wilson SA, Westerterp KR (1999) Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur J Clin Nutr 53:495–502

    Article  CAS  PubMed  Google Scholar 

  33. 33.

    Mattes R (1990) Hunger ratings are not a valid proxy measure of reported food intake in humans. Appetite 15:103–113

    Article  CAS  PubMed  Google Scholar 

  34. 34.

    Walston J, Andersen RE, Seibert M, Hilfiker H, Beamer B, Blumenthal J, Poehlman ET (2003) Arg64 beta3-adrenoceptor variant and the components of energy expenditure. Obes Res 11:509–511

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Ms. Rachel Clarke for her assistance with the clinical trial. We gratefully acknowledge and thank the study participants and their families for their time and contribution to the study. This study was funded by the Monash University Faculty of Medicine, Nursing and Health Science Strategic Grant.

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Authors

Contributions

KN contributed to the design of the study, drafted the initial manuscript, designed the data collection instruments, recruited participants, coordinated and supervised data collection, and analysed the data. MPB, HT, and CEH contributed to the conceptualisation and design of the study, supervised data collection, and analysed the data. JB contributed to the conceptualisation and design of the study and recruited participants. All authors reviewed and revised the manuscript, and approved the final manuscript as submitted.

Corresponding author

Correspondence to Kay Nguo.

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The authors declare that they have no conflict of interest.

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Nguo, K., Huggins, C.E., Truby, H. et al. Effect of macronutrient composition on meal-induced thermogenesis in adolescents with obesity. Eur J Nutr 58, 2327–2333 (2019). https://doi.org/10.1007/s00394-018-1783-1

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Keywords

  • Obesity
  • Adolescent
  • Acute feeding
  • Meal-induced thermogenesis
  • Macronutrients