Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men
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Serum γ-glutamyltransferase (GGT) has been proposed as a marker of oxidative stress. Here, we examined the association between serum GGT and the dietary intake of polyphenols, which have antioxidant properties.
A cross-sectional survey including 7960 apparently healthy Japanese men (aged 22–86 years) who participated in health checkups was conducted in Shizuoka, Japan. We analyzed these subjects’ clinical serum parameters and lifestyle factors, including dietary polyphenol intake, which was evaluated by a self-administered questionnaire and by matching the subjects’ food consumption data with our original polyphenol content database.
The average intake of polyphenols was 1157 ± 471 mg/day, and green tea was the largest source of polyphenols at 40%, followed by coffee at 36%. Dividing the population according to quintiles of total polyphenol intake, the difference in polyphenol intake from coffee between the groups was much greater than the difference in polyphenol intake from green tea. The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake. The GGT levels were inversely associated with the polyphenol intake from coffee, but not with that from green tea. Multivariable linear regression analyses demonstrated that the subjects’ GGT levels were negatively and independently associated with their polyphenol intake.
The intake of total polyphenol including coffee as a major contributor is inversely associated with the serum GGT concentration in Japanese males.
KeywordsPolyphenol intake Gamma-glutamyltransferase Green tea Coffee GGT
This study was financially supported by a Grant-in-Aid for Scientific Research (26282027) and the Global COE Program of the Center of Excellence for Innovation in Human Health Sciences from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest associated with this manuscript.
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