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Dietary total antioxidant capacity and incidence of chronic kidney disease in subjects with dysglycemia: Tehran Lipid and Glucose Study

European Journal of Nutrition volume 57, pages 2377–2385 (2018)Cite this article

Abstract

Purpose

We aimed to investigate the association of dietary total antioxidant capacity (TAC) with incidence of CKD in subjects with dysglycemia.

Methods

We followed-up 1179 subjects aged ≥30 years with dysglycemia from the Tehran Lipid and Glucose Study (TLGS) for 3 years, who were initially free of CKD. Dietary intakes of TAC, vitamin C, vitamin E, and β-carotene were assessed by a food-frequency questionnaire at the baseline. Dietary TAC was estimated using the oxygen radical absorbance capacity method. Estimated glomerular filtration rate (eGFR) was calculated, using the Modification of Diet in Renal Disease Study equation and CKD was defined as eGFR <60 mL/min/1.73 m2. Odds ratios (ORs) using multivariable logistic regression were reported for the association of incident CKD with dietary TAC.

Results

A total of 197 (16.7%) cases of incident CKD were recorded after 3 years of follow-up. After adjustment for age, sex, smoking, physical activity, body mass index, hypertension, and total energy intake, the top tertile of dietary TAC compared to the bottom was associated with 39% [95% confidence interval (CI) = 0.40–0.93] lower risk of incident CKD (P for trend = 0.025). Furthermore, the highest tertile of vitamin C intake compared to the lowest risk of incident CKD was decreased (OR 0.60; 95% CI 0.38–0.93, P trend 0.023). Intakes of vitamin E and β-carotene were not significantly associated with incident CKD risk.

Conclusion

Our findings suggest that diets high in TAC are associated with a lower risk of incident CKD among subjects with hyperglycemia after 3 years of follow-up.

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Fig. 1

Abbreviations

TAC:

Total antioxidant capacity

CKD:

Chronic kidney disease

FCT:

Food composition table

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Acknowledgements

The authors express their appreciation to the participants in the Tehran Lipid and Glucose Study for their enthusiastic support, and the staff of the Tehran Lipid and Glucose Study Unit of the Research Institute for Endocrine Sciences, for their valuable help. We would like to acknowledge Ms. Niloofar Shiva for a critical edition of English grammar and syntax of the manuscript. This work was funded by a Grant from the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Affiliations

  1. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Golaleh Asghari, Emad Yuzbashian, Sahar Shahemi, Zahra Gaeini & Parvin Mirmiran

  2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, PO Box 19395-4763, Tehran, Iran

    Parvin Mirmiran

  3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fereidoun Azizi

Authors
  1. Golaleh Asghari
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  2. Emad Yuzbashian
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  3. Sahar Shahemi
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  4. Zahra Gaeini
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  5. Parvin Mirmiran
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Correspondence to Parvin Mirmiran.

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Asghari, G., Yuzbashian, E., Shahemi, S. et al. Dietary total antioxidant capacity and incidence of chronic kidney disease in subjects with dysglycemia: Tehran Lipid and Glucose Study. Eur J Nutr 57, 2377–2385 (2018). https://doi.org/10.1007/s00394-017-1511-2

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  • DOI: https://doi.org/10.1007/s00394-017-1511-2

Keywords

  • Total antioxidant capacity
  • Incident CKD
  • Vitamin C
  • Free radical
  • Oxidative stress