European Journal of Nutrition

, Volume 57, Issue 6, pp 2133–2145 | Cite as

Serum antioxidant capacity, biochemical profile and body composition of breast cancer survivors in a randomized Mediterranean dietary intervention study

  • Maria SkouroliakouEmail author
  • D. Grosomanidis
  • P. Massara
  • C. Kostara
  • P. Papandreou
  • D. Ntountaniotis
  • G. Xepapadakis
Original Contribution



Increasing evidence suggests that Mediterranean Diet (MD) is correlated with reduced risk of breast cancer (BC) and cancer mortality, since it modifies patients’ serum antioxidant capacity, body composition and biochemical parameters. The aim of the study was to investigate whether a dietary intervention based on MD has a beneficial effect on these factors.


In this intervention study, seventy female BC survivors were randomly assigned to (1) the intervention group (personalized dietary intervention based on MD) and (2) the control group (received the updated American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and ad libitum diet). Both groups were assessed twice [beginning, end of study (after 6 months)] regarding their anthropometric and biochemical parameters, serum vitamin C, vitamin A, a-tocopherol and CoQ10 levels, dietary intake and adherence to MD. An additional intermediate analysis was conducted on participants’ body composition and biochemical profile.


Concerning the intervention group, body weight, body fat mass, waist circumference, body mass index as well as HDL-cholesterol were significantly decreased (P < 0.2%). An increase was observed in the vitamin C levels in blood (P < 0.2%). In the control group, body weight, body fat mass and serum total cholesterol rose (P < 0.2%). At the end of the study the two groups were significantly different considering blood glucose, vitamin C, polyunsaturated fatty acids, vitamin A and a-tocopherol levels.


This randomized dietary intervention based on MD managed to ameliorate serum antioxidant capacity, body composition, adherence to MD and glycemic profile of postmenopausal BC survivors.


Breast cancer survivors Mediterranean diet Dietary antioxidants Body composition Biochemical profile 



The authors would like to express their gratitude to all the volunteers who participated in the study. The authors would like also to express their very great appreciation to (1) Nikolaos Skourlis for his help in the Supplementary material and to (2) Anna Maria Maragaki for her help concerning data collection.

Compliance with ethical standards

Conflict of interest

M. Skouroliakou, D. Grosomanidis, P. Massara, C. Kostara, P. Papandreou, D. Ntountaniotis and G. Xepapadakis reported no conflict of interest related to the study.

Supplementary material

394_2017_1489_MOESM1_ESM.docx (28 kb)
Supplementary material 1 (DOCX 28 kb)


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Maria Skouroliakou
    • 1
    Email author
  • D. Grosomanidis
    • 2
  • P. Massara
    • 1
  • C. Kostara
    • 3
  • P. Papandreou
    • 3
  • D. Ntountaniotis
    • 4
  • G. Xepapadakis
    • 2
  1. 1.Department of Nutrition and DieteticsHarokopio University of AthensAthensGreece
  2. 2.“REA” HospitalPalaio FaliroGreece
  3. 3.“IASO” Maternity HospitalAthensGreece
  4. 4.Department of ChemistryNational and Kapodistrian University of AthensAthensGreece

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