European Journal of Nutrition

, Volume 57, Issue 2, pp 607–615 | Cite as

Short-term effects of a green coffee extract-, Garcinia c ambogia- and l-carnitine-containing chewing gum on snack intake and appetite regulation

  • Cecilia Bobillo
  • Graham Finlayson
  • Ana Martínez
  • Daniela Fischman
  • Analisa Beneitez
  • Alejandro J. Ferrero
  • Belisario E. Fernández
  • Marcos A. MayerEmail author
Original Contribution



Different studies have assessed the influence of chewing gum to aid control of appetite and reduce food intake.


The aims of the present study were to evaluate the effects of chewing gum on satiety, food hedonics and snack intake and to explore the potential effects of the combination of Garcinia c ambogia, green coffee extract and l-carnitine on satiety, when administered in a gum format.


This was a prospective study in which 57 subjects randomly received three kinds of treatments, in a crossover design: (1) active gum; (2) placebo gum; and (3) no gum. Food preferences and appetite sensations were evaluated by means of the Leeds Food Preference Questionnaire and visual analog scales.


There was a significant reduction in low-fat sweet snack intake with placebo gum and the active gum compared to no gum and a reduction in high-fat sweet snack intake with the active gum compared to placebo gum and no gum. Total caloric intake was only reduced in the active gum condition. Both the active and placebo gum conditions significantly reduced hunger and prospective food consumption and increased fullness compared to no gum and were associated with a reduced wanting for sweet food in the LFPQ, consistent in a reduction in the relative preference for sweet snacks versus savoury snacks.


This study supports the notion that chewing gum containing nutraceutical products might aid in the control over snack intake and reduce hunger sensations.


Green coffee Garciniacambogia l-Carnitine Chewing gum Satiety 



This study was supported by grants from the University of La Pampa and from ELEA Laboratories S.A.C.I.F. Marcos A. Mayer, Cecilia Bobillo and Belisario E. Fernández are members of the Carrera del Investigador Científico y Tecnológico (CONICET) of Argentina.

Compliance with ethical standards

Conflict of interest

C. Bobillo, G. Finlayson, A. Martínez, D. Fischman, A. Beneitez, A.J. Ferrero, B.E. Fernández and M.A. Mayer have no conflicts of interest.

Supplementary material

394_2016_1347_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 15 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Cecilia Bobillo
    • 1
    • 2
    • 3
  • Graham Finlayson
    • 4
  • Ana Martínez
    • 1
  • Daniela Fischman
    • 1
  • Analisa Beneitez
    • 1
  • Alejandro J. Ferrero
    • 1
    • 2
  • Belisario E. Fernández
    • 3
    • 5
  • Marcos A. Mayer
    • 1
    • 2
    • 3
    Email author
  1. 1.CESIM FoundationSanta RosaArgentina
  2. 2.School of Natural SciencesUniversity of La PampaSanta RosaArgentina
  3. 3.National Council of Scientific and Technological Research (CONICET)Buenos AiresArgentina
  4. 4.School of PsychologyUniversity of LeedsLeedsUK
  5. 5.Department of Pathophysiology, School of Pharmacy and BiochemistryUniversity of Buenos AiresBuenos AiresArgentina

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