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Associations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury with heart rate-corrected QT and JT intervals in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

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Abstract

Purpose

Long-chain omega-3 polyunsaturated fatty acids (PUFA) from fish have been associated with risk of cardiovascular diseases (CVD), especially sudden cardiac death (SCD). Mercury exposure, mainly due fish consumption, has been associated with higher risk. However, the impact of PUFAs or mercury on the ventricular cardiac arrhythmias, which often precede SCD, is not completely known. We investigated the associations of the serum long-chain omega-3 PUFAs and hair mercury with ventricular repolarization, measured by heart rate-corrected QT and JT intervals (QTc and JTc, respectively).

Methods

A total of 1411 men from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study, aged 42–60 years and free of CVD in 1984–1989, were studied.

Results

Serum long-chain omega-3 PUFA concentrations were inversely associated with QTc and JTc (multivariate-adjusted P trend across quartiles = 0.02 and 0.002, respectively) and, during the mean 22.9-year follow-up, with lower SCD risk. However, further adjustments for QTc, JTc or hair mercury did not attenuate the associations with SCD. Hair mercury was not associated with QTc, JTc or SCD risk, but it slightly attenuated the associations of the serum long-chain omega-3 PUFA with QTc and JTc.

Conclusions

Higher serum long-chain omega-3 PUFA concentrations, mainly a marker for fish consumption, were inversely associated with QTc and JTc in middle-aged and older men from Eastern Finland, but QTc or JTc did not attenuate the inverse associations of the long-chain omega-3 PUFA with SCD risk. This suggests that prevention of prolonged ventricular repolarization may not explain the inverse association of the long-chain omega-3 PUFA with SCD risk.

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References

  1. Mozaffarian D, Wu JH (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58:2047–2067

    Article  CAS  Google Scholar 

  2. Billman GE (2013) The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: a critical reassessment. Pharmacol Ther 140:53–80

    Article  CAS  Google Scholar 

  3. Rautaharju PM, Surawicz B, Gettes LS (2009) AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 53:982–991

    Article  Google Scholar 

  4. Crow RS, Hannan PJ, Folsom AR (2003) Prognostic significance of corrected QT and corrected JT interval for incident coronary heart disease in a general population sample stratified by presence or absence of wide QRS complex: the ARIC Study with 13 years of follow-up. Circulation 108:1985–1989

    Article  Google Scholar 

  5. Rautaharju PM, Zhang Z, Prineas R, Heiss G (2004) Assessment of prolonged QT and JT intervals in ventricular conduction defects. Am J Cardiol 93:1017–1021

    Article  Google Scholar 

  6. Morita H, Wu J, Zipes DP (2008) The QT syndromes: long and short. Lancet 372:750–763

    Article  CAS  Google Scholar 

  7. De Bruyne M, Hoes A, Kors J, Hofman A, Van Bemmel J, Grobbee D (1999) Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. Eur Heart J 20:278–284

    Article  Google Scholar 

  8. Billman GE, Kang JX, Leaf A (1997) Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs. Lipids 32:1161–1168

    Article  CAS  Google Scholar 

  9. Mozaffarian D, Prineas RJ, Stein PK, Siscovick DS (2006) Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. J Am Coll Cardiol 48:478–484

    Article  CAS  Google Scholar 

  10. Chrysohoou C, Panagiotakos DB, Pitsavos C, Skoumas J, Krinos X, Chloptsios Y, Nikolaou V, Stefanadis C (2007) Long-term fish consumption is associated with protection against arrhythmia in healthy persons in a Mediterranean region–the ATTICA study. Am J Clin Nutr 85:1385–1391

    CAS  Google Scholar 

  11. Brouwer IA, Zock PL, van Amelsvoort LG, Katan MB, Schouten EG (2002) Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. Am J Cardiol 89:629–631

    Article  CAS  Google Scholar 

  12. Geelen A, Brouwer IA, Zock PL, Kors JA, Swenne CA, Katan MB, Schouten EG (2002) (N-3) fatty acids do not affect electrocardiographic characteristics of healthy men and women. J Nutr 132:3051–3054

    CAS  Google Scholar 

  13. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen T (2012) Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. PLoS One 7:e41046

    Article  CAS  Google Scholar 

  14. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppanen K, Laukkanen JA, Salonen JT (2005) Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 25:228–233

    CAS  Google Scholar 

  15. Wennberg M, Bergdahl IA, Hallmans G, Norberg M, Lundh T, Skerfving S, Stromberg U, Vessby B, Jansson JH (2011) Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden. Am J Clin Nutr 93:27–36

    Article  CAS  Google Scholar 

  16. Roman HA, Walsh TL, Coull BA, Dewailly E, Guallar E, Hattis D, Marien K, Schwartz J, Stern AH, Virtanen JK, Rice G (2011) Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis. Environ Health Perspect 119:607–614

    Article  CAS  Google Scholar 

  17. Houston MC (2011) Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens 13:621–627

    Article  CAS  Google Scholar 

  18. Salonen JT (1988) Is there a continuing need for longitudinal epidemiologic research? The Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Clin Res 20:46–50

    CAS  Google Scholar 

  19. Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R (1992) High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86:803–811

    Article  CAS  Google Scholar 

  20. Lakka TA, Venalainen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT (1994) Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men. N Engl J Med 330:1549–1554

    Article  CAS  Google Scholar 

  21. Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT, Kuopio Ischemic Heart Disease Risk Factor Study (2001) Low dietary folate intake is associated with an excess incidence of acute coronary events: the Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 103:2674–2680

    Article  CAS  Google Scholar 

  22. Laaksonen D, Lakka T, Lakka H, Nyyssönen K, Rissanen T, Niskanen L, Salonen J (2002) Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 19:456–464

    Article  CAS  Google Scholar 

  23. Salonen JT, Seppanen K, Nyyssonen K, Korpela H, Kauhanen J, Kantola M, Tuomilehto J, Esterbauer H, Tatzber F, Salonen R (1995) Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 91:645–655

    Article  CAS  Google Scholar 

  24. Furberg CD, Manolio TA, Psaty BM, Bild DE, Borhani NO, Newman A, Tabatznik B, Rautaharju PM, Cardiovascular Health Study Collaborative Research Group (1992) Major electrocardiographic abnormalities in persons aged 65 years and older (the Cardiovascular Health Study). Am J Cardiol 69:1329–1335

    Article  CAS  Google Scholar 

  25. Statters DJ, Malik M, Ward DE, Camm A (1994) QT dispersion: problems of methodology and clinical significance. J Cardiovasc Electrophysiol 5:672–685

    Article  CAS  Google Scholar 

  26. Ahnve S (1985) Correction of the QT interval for heart rate: review of different formulas and the use of Bazett’s formula in myocardial infarction. Am Heart J 109:568–574

    Article  CAS  Google Scholar 

  27. Butrous GS, Schwartz PJ (1989) Clinical aspects of ventricular repolarization. Farrand Press, London

    Google Scholar 

  28. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A (1994) Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 90:583–612

    Article  CAS  Google Scholar 

  29. IHT Guideline (2005) The non-clinical evaluation of the potential for delayed ventricular repolarization (Qt interval prolongation) by human pharmaceuticals. The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), Geneva, Switzerland. S7B (http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html ). Accessed 6 Dec 2015

  30. Endo J, Arita M (2016) Cardioprotective mechanism of omega-3 polyunsaturated fatty acids. J Cardiol 67:22–27

    Article  Google Scholar 

  31. Zhang Y, Post WS, Dalal D, Bansal S, Blasco-Colmenares E, Jan De Beur S, Alonso A, Soliman EZ, Whitsel EA, Brugada R (2011) Serum 25-hydroxyvitamin D, calcium, phosphorus, and electrocardiographic QT interval duration: findings from NHANES III and ARIC. J Clin Endocrinol Metab 96:1873–1882

    Article  CAS  Google Scholar 

  32. Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47:348–380

    Article  CAS  Google Scholar 

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Acknowledgments

The study was supported by the University of Eastern Finland.

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Authors and Affiliations

  1. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, 70211, Kuopio, Finland

    Behnam Tajik, Sudhir Kurl, Tomi-Pekka Tuomainen & Jyrki K. Virtanen

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  1. Behnam Tajik
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  2. Sudhir Kurl
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  3. Tomi-Pekka Tuomainen
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  4. Jyrki K. Virtanen
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Correspondence to Jyrki K. Virtanen.

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Tajik, B., Kurl, S., Tuomainen, TP. et al. Associations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury with heart rate-corrected QT and JT intervals in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Nutr 56, 2319–2327 (2017). https://doi.org/10.1007/s00394-016-1272-3

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  • DOI: https://doi.org/10.1007/s00394-016-1272-3

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