Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats



The objective of this study was to determine the effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats (SHRs).


The protein of foxtail millet after extruding or fermenting and the raw foxtail millet was extracted and hydrolyzed by digestive protease to generate angiotensin-converting enzyme (ACE) inhibitory peptides. The potential antihypertensive effect of protein hydrolysates from foxtail millet in SHRs was investigated.


After 4 weeks of treatment with 200 mg peptides/kg of body weight of protein hydrolysates, blood pressure was lowered significantly, and the raw and extruded samples were more effective than the fermented samples. The serum ACE activity and angiotensin II levels in the treatment groups were significantly lower than that of the control. The percent heart weight decreased in the treatment groups.


Thus, ingestion of foxtail millet protein hydrolysates especially for the raw and extruded hydrolysates may ameliorate hypertension and alleviate related cardiovascular diseases.

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This work was financially supported by the China Agricultural Research System (No. CARS-07-12.5).

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Correspondence to Qun Shen.

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Chen, J., Duan, W., Ren, X. et al. Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats. Eur J Nutr 56, 2129–2138 (2017). https://doi.org/10.1007/s00394-016-1252-7

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  • Angiotensin-converting enzyme
  • Angiotensin II
  • Antioxidant
  • Foxtail millet protein hydrolysates
  • Hypertension
  • Spontaneously hypertensive rats