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A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile

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Abstract

Purpose

The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels.

Methods

Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included.

Results

M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD −1.04, 95 % CI −1.36, −0.73), 60 min (MD −0.87, 95 % CI −1.27, −0.48) and 90 min (MD −0.55, 95 % CI −0.87, −0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba.

Conclusion

Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.

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Abbreviations

MD:

Mean difference

CI:

Confidence interval

PPG:

Postprandial glucose

FBS:

Fasting blood sugar

HbA1C:

Hemoglobin A1C

HOMA-IR:

Homeostatic model assessment insulin resistance

TC:

Total cholesterol

TG:

Triglyceride

LDL:

Low density lipoprotein cholesterol

HDL:

High-density lipoprotein cholesterol

PRISMA:

Preferred reporting items for systematic reviews and meta-analyses

SE:

Standard error

RCT:

Randomized control trial

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Acknowledgments

The authors wish to thank Dr. Pamela Voulalas, School of Pharmacy, University of Maryland for language editorial assistance.

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Correspondence to Wiraphol Phimarn.

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Phimarn, W., Wichaiyo, K., Silpsavikul, K. et al. A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile. Eur J Nutr 56, 1509–1521 (2017). https://doi.org/10.1007/s00394-016-1197-x

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