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Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

European Journal of Nutrition volume 56, pages 1157–1168 (2017)Cite this article

Abstract

Purpose

Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods

Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th–75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8–53.1) pmol/g Hb and 34.2 (25.4–46.9) pmol/g Hb, respectively.

Results

The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively.

Conclusions

Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.

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Acknowledgments

This work was supported by the Wereld Kanker Onderzoek Fonds (WCRF NL) [Grant WCRF 2011/442] and by the Health Research Fund (FIS) of the Spanish Ministry of Health [Exp PI11/01473]. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Health Research Fund (FIS) of the Spanish Ministry of Health, Regional Governments of Andalucía, Asturias, Basque Country, Murcia [no. 6236], Navarra and the Catalan Institute of Oncology, La Caixa [BM 06-130], Red Temática de Investigación Cooperativa en Cáncer [RD12/0036/0018; RD06/0020/0091] (Spain); Danish Cancer Society (Denmark); Ligue contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro (AIRC) and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), the Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) and Statistics Netherlands (the Netherlands); Nordic Center of Excellence in Food, Nutrition and Health-Helga (Norway); Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skåne and Västerbotten (Sweden); Cancer Research UK, Medical Research Council (United Kingdom). MO-S is affiliated with the University of Barcelona.

Author information

Authors and Affiliations

  1. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, L’Hospitalet de Llobregat, 08908, Barcelona, Spain

    Mireia Obón-Santacana, Leila Lujan-Barroso & Eric J. Duell

  2. Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, France

    Heinz Freisling

  3. Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, Inserm, 94805, Villejuif, France

    Claire Cadeau, Guy Fagherazzi & Marie-Christine Boutron-Ruault

  4. UMRS 1018, Université Paris Sud, 94805, Villejuif, France

    Claire Cadeau, Guy Fagherazzi & Marie-Christine Boutron-Ruault

  5. Institut Gustave Roussy, 94805, Villejuif, France

    Claire Cadeau, Guy Fagherazzi & Marie-Christine Boutron-Ruault

  6. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

    Rudolf Kaaks & Renée T. Fortner

  7. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114/116, 14558, Nuthetal, Germany

    Heiner Boeing

  8. Public Health and Participation Directorate, Ciriaco Miguel Vigil 9, 33009, Asturias, Spain

    J. Ramón Quirós

  9. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs. GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Cuesta del Observatorio, 4, Campus Universitario de Cartuja, 18080, Granada, Spain

    Esther Molina-Montes

  10. CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, 28029, Madrid, Spain

    Esther Molina-Montes, José María Huerta Castaño & Eva Ardanaz

  11. Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Avda. Navarra, 4, 20013, San Sebastián, Spain

    Saioa Chamosa

  12. Department of Epidemiology, Murcia Regional Health Authority, Ronda de Levante, 11, 30008, Murcia, Spain

    José María Huerta Castaño

  13. Navarre Public Health Institute, Polígono de Landaben C/F, 31012, Pamplona, Spain

    Eva Ardanaz

  14. University of Cambridge School of Clinical Medicine, Robinson Way, Cambridge, CB2 0SR, UK

    Kay-Tee Khaw

  15. MRC Epidemiology Unit, University of Cambridge, 184 Hills Road, Cambridge, CB2 8PQ, UK

    Nick Wareham

  16. Cancer Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK

    Tim Key

  17. Hellenic Health Foundation, 13 Kaisareias Street, 115 27, Athens, Greece

    Antonia Trichopoulou & Androniki Naska

  18. Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, 115 27, Athens, Greece

    Antonia Trichopoulou

  19. Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, 115 27, Athens, Greece

    Pagona Lagiou & Androniki Naska

  20. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA

    Pagona Lagiou

  21. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Ponte Nuovo, Via delle Oblate n.2, 50141, Florence, Italy

    Domenico Palli

  22. Epidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133, Milan, Italy

    Sara Grioni

  23. Cancer Registry and Histopathology Unit, “Civic-M.P.Arezzo” Hospital, Via Civile, 97100, Ragusa, Italy

    Rosario Tumino

  24. Human Genetics Foundation (HuGeF), Via Nizza 52, 10126, Turin, Italy

    Paolo Vineis

  25. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK

    Paolo Vineis, H. B. Bueno-de-Mesquita, Petra H. Peeters & Elio Riboli

  26. Department of Clinical and Experimental Medicine, Federico II University, Corso Umberto I, 40bis, 80138, Naples, Italy

    Maria Santucci De Magistris

  27. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    H. B. Bueno-de-Mesquita

  28. Department of Gastroenterology and Hepatology, University Medical Centre, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

    H. B. Bueno-de-Mesquita

  29. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia

    H. B. Bueno-de-Mesquita

  30. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Huispost Str. 6.131, 3508GA, Utrecht, The Netherlands

    Petra H. Peeters

  31. Department of Public Health and Clinical Medicine, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, 901 85, Umeå, Sweden

    Maria Wennberg

  32. Department of Biobank Research, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, 901 85, Umeå, Sweden

    Ingvar A. Bergdahl

  33. Centers for Disease Control and Prevention, MS F25, 4770 Buford Hwy NE, Atlanta, GA, 30341, USA

    Hubert Vesper

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  1. Mireia Obón-Santacana
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Correspondence to Eric J. Duell.

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The authors declare that they have no conflict of interest. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

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Obón-Santacana, M., Lujan-Barroso, L., Freisling, H. et al. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort. Eur J Nutr 56, 1157–1168 (2017). https://doi.org/10.1007/s00394-016-1165-5

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Keywords

  • Acrylamide
  • Glycidamide
  • Hemoglobin adducts
  • Biomarkers
  • Diet
  • Nutrition