European Journal of Nutrition

, Volume 56, Issue 2, pp 819–830 | Cite as

Metabolic syndrome and selenium during gestation and lactation

  • Fátima Nogales
  • M. Luisa Ojeda
  • Paulina Muñoz del Valle
  • Alejandra Serrano
  • M. Luisa Murillo
  • Olimpia Carreras Sánchez
Original Contribution



Selenium (Se) has a dual role in metabolic syndrome (MS) development as it has an antioxidant action against both “good” and “bad” reactive oxygen species. This study evaluates Se body profile in dams which present MS during gestation and lactation, in order to elucidate a normal dietary Se’s implication in this pathology.


Rats were randomized into control (C) and fructose (F) groups. The rich fructose diet (65 %) during gestation and lactation periods induced MS in dams. Se body distribution was determined by atomic absorption spectrophotometry, and the hepatic activity of the four antioxidant enzymes and the bimolecular oxidation were determined by spectrophotometry. The cardiac activity was monitored using the indirect tail occlusion method. Lipid and glucidic profile was also analyzed.


Despite the fact that the diet supplied has 0.1 ppm of Se, the minimal dietary requirement for rats, F dams ate less amount of food, and therefore, they had lower Se retention. However, they had normal levels of Se in serum and milk. Dams with MS had Se depletion in heart and muscle joint to hypertension and a lower heart rate, and Se repletion in liver and kidney. Despite the increase in hepatic glutathione peroxidase (GPx) and catalase activity found, lipid oxidation occurred—probably because superoxide dismutase activity was diminished. In heart, the activity and expression of the selenoprotein GPx1 were decreased.


With these results, it is not possible to elucidate whether a dietary Se supplementation or a Se-restricted diet are good for MS; because despite the fact that GPx activity is increased in liver, it is also found, for the first time, that heart Se deposits are significantly decreased during MS.


Metabolic syndrome Selenium Gestation Lactation 



The authors acknowledge the grants from Andalusian Regional Government for its support to CTS-193 research group.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Fátima Nogales
    • 1
  • M. Luisa Ojeda
    • 1
  • Paulina Muñoz del Valle
    • 1
  • Alejandra Serrano
    • 1
  • M. Luisa Murillo
    • 1
  • Olimpia Carreras Sánchez
    • 1
  1. 1.Department of Physiology, Faculty of PharmacySeville UniversitySevilleSpain

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