Dietary magnesium intake and the risk of diabetes in the Japanese community: results from the Takayama study
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Several experimental studies showed that magnesium intake improved insulin resistance and glucose uptake in diabetes patients. However, epidemiological studies on the association between magnesium intake and diabetes risk have yielded inconsistent results. We investigated whether magnesium intake is related to the risk of developing diabetes in a population-based cohort study in Japan.
Study subjects were participants in the Takayama study. A total of 13,525 residents in Takayama City, Japan, responded to a self-administered questionnaire in 1992 and to a follow-up questionnaire seeking information about diabetes in 2002. Magnesium and other nutrient intakes were estimated from a validated food frequency questionnaire administered at the baseline.
During a follow-up of 10 years, 438 subjects reported diabetes newly diagnosed by physician. Compared with women in the low quartile of magnesium intake, women in the high quartile were at a significantly reduced risk of diabetes (HR 0.50; 95 % CI 0.30–0.84; P-trend 0.005) after adjustments for covariates. In men, there was no association between magnesium intake and the risk of diabetes.
These results suggest that diets with a high intake of magnesium may decrease the risk of diabetes in women.
KeywordsMagnesium Diabetes Prospective studies Diet The Japanese
Food frequency questionnaire
Our study has been financially supported by the National Cancer Center Research and Development Fund and the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The manuscript does not contain clinical studies or patient data.
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