Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status
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The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months.
The study was conducted in Halle (Saale), Germany (51o northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20–71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D3 dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes.
Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation, although serum 25-hydroxyvitamin D3 increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile.
Daily supplementation of 20 µg vitamin D3 during winter is unlikely to change cardiovascular risk profile.
KeywordsVitamin D3 Supplementation Cardiovascular risk Monocyte subsets Adults
Body mass index
Bone morphogenetic protein 2
Coefficient of variance
Dickkopf-related protein 1
Fluorescence-activated cell sorting
Mean corpuscular haemoglobin
Mean corpuscular haemoglobin concentration
Mean corpuscular volume
Major histocompatibility complex
Receptor activator of nuclear factor kappa-B ligand
Randomised controlled trial
Large ribosomal protein
Rate pressure product
Runt-related transcription factor 2
Tumour necrosis factor α
Toll-like receptor 2
Vitamin D receptor
This study was supported by a Grant from The Federal Ministry of Education and Research of Germany (01EA1323A). We thank B. Heinze and M. Hajri for their excellent technical assistance and record keeping. We thank Dr. B. Ludwig-Kraus and colleagues for determination of differential blood counts at the central laboratory unit of the University Hospital Halle (UKH, Ernst-Grube-Str. 40, 06120 Halle/Saale, Germany).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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