European Journal of Nutrition

, Volume 56, Issue 2, pp 621–634 | Cite as

Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status

  • Eric Seibert
  • Ulrike Lehmann
  • Annett Riedel
  • Christof Ulrich
  • Frank Hirche
  • Corinna Brandsch
  • Jutta Dierkes
  • Matthias Girndt
  • Gabriele I. Stangl
Original Contribution

Abstract

Purpose

The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months.

Methods

The study was conducted in Halle (Saale), Germany (51o northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20–71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D3 dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes.

Results

Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation, although serum 25-hydroxyvitamin D3 increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile.

Conclusion

Daily supplementation of 20 µg vitamin D3 during winter is unlikely to change cardiovascular risk profile.

Keywords

Vitamin D3 Supplementation Cardiovascular risk Monocyte subsets Adults 

Abbreviations

BMI

Body mass index

BMP2

Bone morphogenetic protein 2

BP

Blood pressure

CV

Cardiovascular

COV

Coefficient of variance

DKK1

Dickkopf-related protein 1

FACS

Fluorescence-activated cell sorting

HDL

High-density lipoprotein

IL-10

Interleukin 10

LDL

Low-density lipoprotein

MCH

Mean corpuscular haemoglobin

MCHC

Mean corpuscular haemoglobin concentration

MCV

Mean corpuscular volume

MCH

Major histocompatibility complex

OPG

Osteoprotegerin

RANKL

Receptor activator of nuclear factor kappa-B ligand

RCT

Randomised controlled trial

RPLP0

Large ribosomal protein

RPP

Rate pressure product

RUNX2

Runt-related transcription factor 2

TNFα

Tumour necrosis factor α

TLR2

Toll-like receptor 2

VDR

Vitamin D receptor

25(OH)D

25-Hydroxyvitamin D

Notes

Acknowledgments

This study was supported by a Grant from The Federal Ministry of Education and Research of Germany (01EA1323A). We thank B. Heinze and M. Hajri for their excellent technical assistance and record keeping. We thank Dr. B. Ludwig-Kraus and colleagues for determination of differential blood counts at the central laboratory unit of the University Hospital Halle (UKH, Ernst-Grube-Str. 40, 06120 Halle/Saale, Germany).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

394_2015_1106_MOESM1_ESM.pdf (105 kb)
Supplementary material 1 (PDF 104 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Eric Seibert
    • 1
  • Ulrike Lehmann
    • 2
  • Annett Riedel
    • 2
  • Christof Ulrich
    • 1
  • Frank Hirche
    • 2
  • Corinna Brandsch
    • 2
  • Jutta Dierkes
    • 3
  • Matthias Girndt
    • 1
  • Gabriele I. Stangl
    • 2
  1. 1.Department of Internal Medicine IIMartin Luther University Halle-WittenbergHalle/SaaleGermany
  2. 2.Institute of Agricultural and Nutritional SciencesMartin Luther University Halle-WittenbergHalle/SaaleGermany
  3. 3.Department of Clinical MedicineUniversity of BergenBergenNorway

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