Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia
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Green tea may have a beneficial role of inhibiting leukemia. Glutathione S-transferases (GSTs) are known to detoxify certain carcinogens. We investigated the roles of green tea consumption and polymorphisms of GSTM1, GSTT1 and GSTP1 on the risk of adult leukemia, and to determine whether the associations varied within GSTs genotypes.
A multicenter case–control study was conducted in China, 2008–2013. It comprised 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium and study site. Data were collected by face-to-face interview using a validated questionnaire. Genetic polymorphisms were assayed by PCR.
An inverse association between green tea consumption and adult leukemia risk was observed. Compared with non-tea drinkers, the adjusted odds ratios (95 % confidence intervals) were 0.50 (0.27–0.93), 0.31 (0.17–0.55) and 0.53 (0.29–0.99) for those who, respectively, consumed green tea >20 years, ≥2 cups daily and dried tea leaves >1000 g annually. In assessing the associations by GSTs genotypes, risk reduction associated with green tea consumption was stronger in individuals with the GSTT1-null genotype (OR 0.24; 95 % CI 0.11–0.53) than GSTT1-normal carriers (OR 0.67; 95 % CI 0.42–1.05; P interaction = 0.02). GSTM1 and GSTP1 did not significantly modify the inverse association of leukemia with green tea.
The results suggest that regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype and highlights further study.
KeywordsGreen tea Adult leukemia GST Genetic polymorphism Gene–diet interaction
The authors are grateful to the participants in this study for their cooperation. The authors would also like to thank the staff from the three participating hospitals and Zhejiang University Women’s Hospital for their kind assistance with fieldwork. The first author was supported by the Scholarship for International Research Fees and the University Postgraduate Award of The University of Western Australia.
This work was funded by the National Health and Medical Research Council (Australia) Project Grant (Grant Number 572542).
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Conflict of interest
- 2.Strange RC, Fryer AA (1999) The glutathione S-transferases: influence of polymorphism on cancer susceptibility. In: Vineis P, Malats N, Lang M, d’Errico A, Caporaso N, Cuzick J, Boffetta P (eds) Metabolic polymorphisms and susceptibility to cancer. IARC Scientific Publications, Lyon, pp 231–249Google Scholar
- 6.Sonoda J, Koriyama C, Yamamoto S, Kozako T, Li HC, Lema C, Yashiki S, Fujiyoshi T, Yoshinaga M, Nagata Y, Akiba S, Takezaki T, Yamada K, Sonoda S (2004) HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. Cancer Sci 95:596–601CrossRefGoogle Scholar
- 13.Gao CM, Takezaki T, Wu JZ, Li ZY, Liu YT, Li SP, Ding JH, Su P, Hu X, Xu TL, Sugimura H, Tajima K (2002) Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case–control study of a high-incidence area in Jiangsu Province, China. Cancer Lett 188:95–102CrossRefGoogle Scholar
- 17.Zhang ZN, Shen D (2007) The standards of diagnosis and treatment in haematology, 3rd edn. Science Press, BeijingGoogle Scholar
- 18.Zhang M, Binns CW, Lee AH (2002) Tea consumption and ovarian cancer risk: a case–control study in China. Cancer Epidemiol Biomarkers Prev 11:713–718Google Scholar
- 23.Breslow NE, Day NE (1980) Volume 1—the analysis of case–control studies. In: Davis W (ed) Statistical method in cancer research. IARC Scientific Publications, Lyon, pp 162–191Google Scholar
- 24.Rothman KJ, Greenland S, Lash TL (2008) Modern epidemiology, 3rd edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
- 34.International Agency for Research on Cancer (2012) IARC monographs on the evaluation of carcinogenic risks to humans. Benzene. In: Chemical agents and related occupations, vol 100F. WHO, LyonGoogle Scholar
- 35.International Agency for Research on Cancer (2001) IARC monographs on the evaluation of carcinogenic risks to humans. Ionizing radiation. In: Some internally deposited radionuclides, vol 78. WHO, LyonGoogle Scholar