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The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis

European Journal of Nutrition volume 55, pages 2163–2176 (2016)Cite this article

Abstract

Purpose

The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.

Methods

The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle–Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed.

Results

The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27–0.04; p = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38–0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43–0.63; p = 0.71).

Conclusions

This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.

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Author contributions

MJ and MSM designed the study, searched databases, performed the selection of studies and wrote the manuscript. MSM analysed the data; JW contributed to writing the manuscript and commented on it. MW and PB searched databases and commented on the manuscript. JJ commented on the manuscript. All authors reviewed and approved the final manuscript.

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Authors and Affiliations

  1. Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624, Poznan, Poland

    Małgorzata Jamka, Małgorzata Woźniewicz & Jan Jeszka

  2. Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 27/33 Szpitalna Str., 60-572, Poznan, Poland

    Jarosław Walkowiak & Marta Stelmach-Mardas

  3. Department of Education and Obesity Treatment and Metabolic Disorders, Poznan University of Medical Sciences, 84 Szamarzewskiego Str., 60-596, Poznan, Poland

    Paweł Bogdański

  4. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, 114-116 Arthur-Scheunert-Allee, 14558, Nuthetal, Germany

    Marta Stelmach-Mardas

Authors
  1. Małgorzata Jamka
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  2. Małgorzata Woźniewicz
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  3. Jarosław Walkowiak
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  6. Marta Stelmach-Mardas
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Correspondence to Marta Stelmach-Mardas.

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Jamka, M., Woźniewicz, M., Walkowiak, J. et al. The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis. Eur J Nutr 55, 2163–2176 (2016). https://doi.org/10.1007/s00394-015-1089-5

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Keywords

  • Vitamin D
  • Adipokines
  • C-reactive protein
  • Cytokines
  • Dietary supplements
  • Obesity

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