Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
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Dietary flavonoids, including anthocyanins, may positively influence cognition and may be beneficial for the prevention and treatment of dementia. We aimed to assess whether daily consumption of anthocyanin-rich cherry juice changed cognitive function in older adults with dementia. Blood pressure and anti-inflammatory effects were examined as secondary outcomes.
A 12-week randomised controlled trial assessed cognitive outcomes in older adults (+70 year) with mild-to-moderate dementia (n = 49) after consumption of 200 ml/day of either a cherry juice or a control juice with negligible anthocyanin content. Blood pressure and inflammatory markers (CRP and IL-6) were measured at 6 and 12 weeks. ANCOVA controlling for baseline and RMANOVA assessed change in cognition and blood pressure.
Improvements in verbal fluency (p = 0.014), short-term memory (p = 0.014) and long-term memory (p ≤ 0.001) were found in the cherry juice group. A significant reduction in systolic (p = 0.038) blood pressure and a trend for diastolic (p = 0.160) blood pressure reduction was evident in the intervention group. Markers of inflammation (CRP and IL-6) were not altered.
Inclusion of an anthocyanin-rich beverage may be a practical and feasible way to improve total anthocyanin consumption in older adults with mild-to-moderate dementia, with potential to improve specific cognitive outcomes.
KeywordsCherry Cognition Anthocyanin Dementia
Agritechnology Pty Ltd for producing and supplying in kind the juice utilised in this research.
This work was supported by the Illawarra Health and Medical Research Institute (IHMRI).
- 1.Leather S (1995) Fruit and vegetables: consumption patterns and health consequences. Food J Hyg Rev 97:10Google Scholar
- 6.Notas G, Nifli AP, Castanas E, Kampa M (2007) Polyphenols and cancer cell growth, vol 159. Springer, Berlin, Heidelberg, pp 79–113Google Scholar
- 7.Vauzour D, Rendeiro C, Spencer JPE (2009) Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys 492(1–2):1–9Google Scholar
- 14.USDA (2013) United States Department of Agriculture Database for the flavonoid content of selected foods. Release 3:1Google Scholar
- 16.Bondonno CP, Swinny E, Mubarak A, Hodgson JM, Downey LA, Croft KD, Scholey A, Stough C, Yang X, Considine MJ, Ward NC, Puddey IB (2014) The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women. Food Funct 5(5):849–858. doi: 10.1039/c3fo60590f CrossRefGoogle Scholar
- 31.Cohen J (1988) Statistical power analysis for the behavioral sciences. Erlbaum Associates, HillsdaleGoogle Scholar