Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old children
Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose–response investigation considering whether these cognitive benefits extend to children.
Using a double-blind cross-over design, on three occasions children (n = 21; 7–10 years) consumed placebo (vehicle) or blueberry drinks containing 15 or 30 g freeze-dried wild blueberry (WBB) powder. A cognitive battery including tests of verbal memory, word recognition, response interference, response inhibition and levels of processing was performed at baseline, and 1.15, 3 and 6 h following treatment.
Significant WBB-related improvements included final immediate recall at 1.15 h, delayed word recognition sustained over each period, and accuracy on cognitively demanding incongruent trials in the interference task at 3 h. Importantly, across all measures, cognitive performance improved, consistent with a dose–response model, with the best performance following 30 g WBB and the worst following vehicle.
Findings demonstrate WBB-related cognitive improvements in 7- to 10-year-old children. These effects would seem to be particularly sensitive to the cognitive demand of task.
KeywordsFlavonoid Children Anthocyanin Cognition Memory Executive function
Compliance with ethical standards
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
- 9.Kirby A, Woodward A, Jackson S, Wang Y, Crawford MA (2010) A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8–10 years from a mainstream school population. Res Dev Disabil 31:718–730. doi: 10.1016/j.ridd.2010.01.014 CrossRefGoogle Scholar
- 10.Vita JA (2005) Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 81:292S–297SGoogle Scholar
- 18.Williams CM, El Mohsen MA, Vauzour D et al (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 45:295–305. doi: 10.1016/j.freeradbiomed.2008.04.008 CrossRefGoogle Scholar
- 22.Ryan J, Croft K, Wesnes K et al (2008) An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocronological and oxidative stress biomarkers in an elderly population. J Psychopharmacol 5:553–562. doi: 10.1006/nimg.2000.0685 CrossRefGoogle Scholar
- 26.Lamport DJ, Pal D, Mousiana C, Field DT, Williams CM, Spencer JPE, Butler LT (2015) The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology 232:3227–3234. doi: 10.1007/s00213-015-3972-4 CrossRefGoogle Scholar
- 27.Dodd FD (2012) The acute effects of flavonoid-rich blueberries on cognitive function in healthy younger and older adults. Dissertation. University or ReadingGoogle Scholar
- 39.Lezak MD, Howieson DB, Loring DW (2004) Neuropsychological assessment. Oxford University Press, OxfordGoogle Scholar
- 46.Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23:6690–6694Google Scholar
- 48.Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Hiess C, Spencer JP (2013) Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98:1179–1191. doi: 10.3945/ajcn.113.066639 CrossRefGoogle Scholar