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Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study

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Abstract

Purpose

Coffee and green tea consumption may be associated with circulating adipokines, but data are inconsistent, scarce or lacking. We examined the association of coffee and green tea consumption with serum adiponectin, leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1) among a Japanese working population.

Methods

The authors analyzed data (n = 509) from a cross-sectional survey among Japanese workers aged 20–68 years. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Coffee and green tea consumption was assessed using a validated diet history questionnaire, and caffeine consumption from these beverages was estimated. Multiple regression analysis was performed with adjustment for potential confounding variables.

Results

Coffee consumption was significantly, inversely associated with leptin and PAI-1 (P for trend = 0.007 and 0.02, respectively); compared with subjects consuming <1 cup per day, those consuming ≥4 cups per day had 13 and 10 % lower means of leptin and PAI-1, respectively. Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1). Additionally, we noted a significant positive association between coffee consumption and adiponectin in men (P for trend = 0.046), but not in women (P for trend = 0.43, P for interaction = 0.11). Moreover, there was a positive association between coffee consumption and resistin in current male smokers (P for trend = 0.01), but not in male non-smokers (P for trend = 0.35, P for interaction = 0.11). Green tea consumption was not associated with any adipokine.

Conclusions

Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.

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Acknowledgments

We are grateful to the study participants for their cooperation and participation. We also thank Seiko Miyazaki and Yasutaka Horiuchi (Kyushu University); Emi Tanaka, Youko Tsuruda, Misaki Hirose, Meishu Sai, Miho Isayama, Midori Sasaki, Mie Shimomura and Azumi Uehara (Fukuoka Women’s University); Yaeko Nagano (retired nurse); and Akiko Hayashi, Yu Teruyama, Kae Saito, Kayoko Washizuka and Yuho Mizoue (National Center for Global Health and Medicine) for their help in data collection. We extend our thanks to Kazuko Nagase and Dai Suzuki (Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine) for their contributions to measurements of serum adipokines. This study was supported by a Grant-in-Aid for Scientific Research (B) (21390213) from the Japan Society for the Promotion of Science (To Dr Mizoue), a Grant-in-Aid for Young Scientists (B) (21790598) from the Ministry of Education, Culture, Sports, Science and Technology and a Grant of National Center for Global Health and Medicine (To Dr Nanri).

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Authors and Affiliations

  1. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Toyama 1-21-1, Shinjuku-ku, Tokyo, 162-8655, Japan

    Ngoc Minh Pham, Akiko Nanri, Kayo Kurotani, Keisuke Kuwahara, Shamima Akter & Tetsuya Mizoue

  2. Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan

    Kazuki Yasuda

  3. Department of Applied Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan

    Masao Sato

  4. Graduate School of Nutrition and Health Science, Fukuoka Women’s University, Fukuoka, Japan

    Hitomi Hayabuchi

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  1. Ngoc Minh Pham
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  2. Akiko Nanri
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  3. Kazuki Yasuda
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  4. Kayo Kurotani
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  5. Keisuke Kuwahara
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  7. Masao Sato
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  8. Hitomi Hayabuchi
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  9. Tetsuya Mizoue
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Correspondence to Ngoc Minh Pham.

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Pham, N.M., Nanri, A., Yasuda, K. et al. Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study. Eur J Nutr 54, 205–214 (2015). https://doi.org/10.1007/s00394-014-0701-4

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