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Freeze-dried powdered yacon: effects of FOS on serum glucose, lipids and intestinal transit in the elderly

Abstract

Background and aims

Freeze-dried powdered yacon (FDY) can be considered a prebiotic product due to its fructooligosaccharides (FOS) content. The effect of 9 weeks of daily intake of FDY containing 7.4 g of FOS on glucose, lipid metabolism and intestinal transit in a group of elderly people was investigated.

Methods

Seventy-two elderly (mean age 67.11 ± 6.11) men and women were studied for 9 weeks in a double-blind, placebo-controlled experiment. They were randomly assigned to the supplement group (which received 7.4 g of FOS as FDY) or the control group. At the beginning and end of the study, anthropometric measurements, blood sampling, clinical analyses and dietary intake were assessed.

Results

A daily intake of FDY containing 7.4 g of FOS for 9 weeks was associated with a mean decrease in serum glucose (p = 0.013), but supplementation did not reduce serum lipids in the study group. The administered dose did not adversely affect intestinal transit. It did not cause bloating, flatulence or intestinal discomfort.

Conclusion

Freeze-dried powdered yacon is a good source of FOS, and daily consumption can have a favourable effect on serum glucose in the elderly. It is also practical, easy and safe to use and store.

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References

  1. Yamori Y (2004) Nutrition and life-style related disease prevention in the future. Clin Exp Pharmacol Physiol 31(Suppl 2):65

    Article  Google Scholar 

  2. Genta S, Cabrera W, Habib N, Pons J, Carillo I, Grau A, Sánchez S (2009) Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clin Nutr 28(2):182–187

    Article  CAS  Google Scholar 

  3. Roberfroid MB, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D et al (2010) Prebiotics effects: metabolic and health benefits. Br J Nutr 104(2):1–63

    Article  Google Scholar 

  4. Reimer RA, Russell JC (2008) Glucose tolerance, lipids, and GLP-1 secretion in JCR:LA-cp rats fed a high protein fiber diet. Obesity (Silver Spring) 16:40–46

    Article  CAS  Google Scholar 

  5. Maurer AD, Chen Q, McPherson C et al (2009) Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood. J Physiol 587:679–691

    Article  CAS  Google Scholar 

  6. Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412

    CAS  Google Scholar 

  7. Cani PD, Neyrinck AM, Maton N, Delzenne NM (2005) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13:1000–1007

    Article  CAS  Google Scholar 

  8. Genta SB, Cabrera WM, Mercado MI, Grau A, Catalán CA, Sánchez SS (2010) Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: constituents of the most active fractions. Chem-Biol Interac 185:143–152

    Article  CAS  Google Scholar 

  9. Roberfroid MB, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D et al (2010) Prebiotics effects: metabolic and health benefits. Brit J Nutr 104(2):1–63

    Article  Google Scholar 

  10. Ouwehand AC, Maekelaëinen H, Tiihonen K, Rautonen N (2007) Digestive health. In: Mitchell H (ed) Sweeteners and sugar alternatives in food technology, 1st edn. Blackwell Publishing Ltd., Oxford, pp 44–53

    Google Scholar 

  11. Alles MS, Roos NM, Baks JC, Lisdonk E, Zock PL, Hautvast JGAJ (1999) Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentration in patients with type 2 diabetes. Am. J. Clin Nutr 69:64–69

    CAS  Google Scholar 

  12. Cummings JH, Pomare EW, Branch WJ, Naylor CPE, MacFarlane GT (1987) Short chain fatty acids in human large intertie, portal, hepatic and venous blood. Gut 28:1221–1227

    Article  CAS  Google Scholar 

  13. Moore N, Chao C, Yang L, Storm H, Oliver-Hemker M, Saavedra JM (2003) Effects of fructooligosaccharide-supplement infant cereal: a double-blind, randomized trial. Brit J Nutr 90:581–587

    Article  CAS  Google Scholar 

  14. Beylot M (2005) Effects of inulin-type fructans on lipid metabolism in man and in animal models. Br J Nutr 93(1):163–168

    Article  Google Scholar 

  15. Yamashita K, Kawai K, Itakura M (1984) Effect of fructooligosaccharides on blood glucose and serum lipids in diabetic subjects. Nutr Res 4:961–966

    Article  CAS  Google Scholar 

  16. Thorburn A, Muir J, Proietto J (1993) Carbohydrate fermentation decreases hepatic glucose output in healthy subjects. Metabolism 42(6):780–788

    Article  CAS  Google Scholar 

  17. Bhatia A, Rani U (2007) Prebiotics and health: clinical implications. J Clin Diagnost Res 6:546–554

    Google Scholar 

  18. Liber A, Szajewska H (2013) Effects of inulin-type fructans on appetite, energy intake, and body weight in children and adults: systematic review of randomized controlled trials. Ann Nut Metab 63:42–54

    Article  CAS  Google Scholar 

  19. Passos ML, Park YK (2003) Frutooligossacarídeos: implicações na saúde humana e utilização em alimentos. Ciência Rural 33(2):385–390

    Article  Google Scholar 

  20. Ojansivu I, Ferreira CL, Salminen S (2011) Yacon, a new source of prebiotic oligosaccharides with a history of safe use. Trends F Sci Technol 22:40–46

    Article  CAS  Google Scholar 

  21. Ohyama T, Itoa O, Yasuyoshia S, Ikarashia T, Minamisawa K, Kubot M, Tsukihashia T, Asamia T (1990) Composition of storage carbohydrate in tubers of yacon (Polymnia sonchifolia). Jpn J Soil Sci Plant Nutr 36(1):167–171

    Article  CAS  Google Scholar 

  22. Hondo M, Nakano A, Okumura Y, Yamaki T (2000) Effects of activated carbon powder treatment on clarification, decolorization, deodorization and fructooligosaccharide content of yacon juice. Nippon Shokuhin Kagaku Kogaku Kaishi 47:148–154

    Article  CAS  Google Scholar 

  23. Bunout D, Barrera G, Hircg S, Gattas V, de la Maza MP, Haschke F, Steenhout P, Klassen P, Hager C (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. JPEN 28:348–354

    Article  CAS  Google Scholar 

  24. Guigoz Y, Rochat F, Perruisseau-Carrier G, Rochat I, Schiffrin EJ (2002) Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people. Nutr Res 22:13–25

    Article  CAS  Google Scholar 

  25. Bouhnik Y, Achour L, Paineau D, Riottot M, Attar A, Bornet F (2007) Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. J Nutr 6:42

    Article  Google Scholar 

  26. Wellman NS (1994) The nutrition screening initiative. Nutr Rev 52(8):44–47

    Article  Google Scholar 

  27. Durnin JVGA, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32:77–97

    Article  CAS  Google Scholar 

  28. Agachan F, Chent T, Pfeifer J, Reisseman P, Wexner DAS (1996) Constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum 39(6):681–685

    Article  CAS  Google Scholar 

  29. Institute of Medicine (2005) Dietary reference intakes for energy carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Food and nutrition board. National Academies Press, Washington

    Google Scholar 

  30. Grethel TCD, Tamashiro WMSs, Maróstica MR, Pstore GM (2013) Yacon (Smallanthus sonchifolius): a functional food. Plant Food Hum Nutr 68(3):222–228

    Article  Google Scholar 

  31. Habib NC, Honoré SM, Genta SB, Sánchez SS (2011) Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats Biochemical approach. Chem Biol Interact 194:31–39

    Article  CAS  Google Scholar 

  32. Neyrinck AM, Delzenne NM (2010) Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders. Curr Opin Clin Nutr Metab Care 13(6):722–728

    Article  CAS  Google Scholar 

  33. Habib NC, Honoré SM, Genta SB, Sánchez SS (2011) Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats: biochemical approach. Chem Biol Interact 194(1):31–39

    Article  CAS  Google Scholar 

  34. Daubioul C, Rousseau N, Demeure R, Gallez, Taper H, Declerck B, Delzenne N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 132:967–973

    CAS  Google Scholar 

  35. Cani PD, Dewever C, Delzenne NM (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like-peptide-1 and ghrelin) in rats. Brit J Nutr 92:521–526

    Article  CAS  Google Scholar 

  36. Baroni S, Suzuki-Kemmelmeier F, Caparroz-Assef SM, Cuman RKN, Bersani-Amado CA (2008) Effect of crude extracts of leaves of Smallanthus sonchifolius (yacon) on glycemia in diabetic rats. Rev Bras Cien Farm 44(3):521–530

    Article  Google Scholar 

  37. Valentová K, Stejskal D, Bartek J, Dvorácková S, Kren V, Ulrichova J, Simanek V (2008) Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment. Food Chem Toxicol 46:1006–1013

    Article  Google Scholar 

  38. Aybar MJ, Riera AAS, Grau A, Grau Sanches SS (2001) Hypoglicemic effect of the water extract of Smallanthus sonchifolius (Yacon) leaves in normal and diabetic rats. J Ethnopharmacol 74:125–132

    Article  CAS  Google Scholar 

  39. Negri G (2005) Diabetes melitos: plantas e princípios ativos naturais hipoglicemiantes. Rev Bras Cienc Farm 41:121–142

    Article  CAS  Google Scholar 

  40. Giacco R, Clemente G, Luongo D et al (2004) Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals. Clin Nutr 23:331–340

    Article  CAS  Google Scholar 

  41. Van Dokkum W, Wezendonk B, Srikumar TS, Van den Heuvel EG (1999) Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young health male subjects. Eur J Clin Nutr 53:1–7

    Article  Google Scholar 

  42. Cumming JH, Macfarlane GT (2002) Gastrointestinal effects of prebiotics. Brit J Nutr 87(2):145–151

    Article  Google Scholar 

  43. Geyer M, Manrique I, Degen L, Beglinger C (2008) Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers. Digestion 78:30–33

    Article  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo—São Paulo Research Foundation—Research Project 2010/50689-7) for financial support and Corn Products Brazil for the supply of maltodextrin.

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Correspondence to M. M. A. Scheid.

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Scheid, M.M.A., Genaro, P.S., Moreno, Y.M.F. et al. Freeze-dried powdered yacon: effects of FOS on serum glucose, lipids and intestinal transit in the elderly. Eur J Nutr 53, 1457–1464 (2014). https://doi.org/10.1007/s00394-013-0648-x

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  • DOI: https://doi.org/10.1007/s00394-013-0648-x

Keywords

  • Freeze-dried powdered yacon
  • Elderly
  • Serum glucose
  • Serum lipids
  • Intestinal transit
  • Fructooligosaccharides