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Dietary patterns and risk of urinary tract tumors: a multilevel analysis of individuals in rural and urban contexts

European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Introduction

Bladder cancer is the fourth most frequently diagnosed malignancy in males in Córdoba, Argentina. The evidence regarding an association between urinary tract tumors and dietary factors still remains controversial. Argentina has particular dietary habits, which have already been associated with cancer occurrence.

Purposes

(a) To estimate the association of typical dietary patterns in Argentina on the occurrence of urinary tract tumors and (b) to assess the urban–rural context of residence and cancer occurrence dependency.

Methods

A case–control study of urinary tract tumors (n = 123, 41/82 cases/controls) was performed in Córdoba Province (Argentina), 2006–2011. A two-level logistic regression model was fitted, taking into account rural–urban residence. An exhaustive probabilistic sensitivity analysis (bias analysis) was performed.

Results

Southern Cone pattern, characterized by red meat, starchy vegetables and wine consumptions (OR 1.75 high versus low level of adherence to the pattern), and a medium adherence to a high-sugar drinks pattern, with high loadings for soft drinks (OR 2.55), were associated with increasing risk of urinary tract tumors. High adherence to the latter pattern was inversely associated (OR 0.72). The occurrence of urinary tract tumors was also linked to place of residence (urban–rural), explaining more than 20 % of outcome variability and improving the above risk estimations.

Conclusions

A high intake of red meat, starchy vegetables and wine, and a moderate intake of high-sugar drinks seem to be associated with increased risk of urinary tract tumors, with differences related to the context of residence.

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Acknowledgments

We would like to thank the National Science and Technology Agency (ANCyT), the Science and Technical Secretary of the University of Córdoba (SECyT-UNC) for financial support (grants PICT 2008-1814, PICT-O 2005-36035 FONCyT and 05/H207 SECyT) and the National Scientific and Technical Research Council (CONICET) for SAP and CN fellowships. Special thanks to Córdoba Cancer Registry (Córdoba, Argentina) and the physicians who participated in this study.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. National Scientific and Technical Research Council (CONICET), Biostatistics Unit, School of Nutrition, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina

    Sonia Alejandra Pou & Camila Niclis

  2. National Institute of Health Science Research (INICSA), National Scientific and Technical Research Council (CONICET-UNC), Cellular Biology, Histology and Embryology Unit, Cellular Biology Institute, Faculty of Medical Sciences, University of Córdoba, Córdoba, Argentina

    Aldo Renato Eynard

  3. Biostatistics Unit, School of Nutrition, Faculty of Medical Sciences and INICSA-CONICET, University of Córdoba, Córdoba, Argentina

    María del Pilar Díaz

  4. Ciudad Universitaria, Av. Enrique Barros s/n, CP 5000, Córdoba, Argentina

    María del Pilar Díaz

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  1. Sonia Alejandra Pou
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  2. Camila Niclis
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  4. María del Pilar Díaz
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Correspondence to María del Pilar Díaz.

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Pou, S.A., Niclis, C., Eynard, A.R. et al. Dietary patterns and risk of urinary tract tumors: a multilevel analysis of individuals in rural and urban contexts. Eur J Nutr 53, 1247–1253 (2014). https://doi.org/10.1007/s00394-013-0627-2

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  • DOI: https://doi.org/10.1007/s00394-013-0627-2

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