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Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study

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Abstract

Purpose

Some researchers found decreased levels of plasma taurine in obese subjects and animals, and reduced expression of an important enzyme of taurine synthesis. These evidences, coupled with the metabolic imbalance of obesity and the possible anti-inflammatory and antioxidant effects of taurine, highlighted the use of taurine as a supplement in obesity treatment. The aim of the present study was to investigate whether taurine supplementation, associated with nutritional counseling, modulates oxidative stress, inflammatory response, and glucose homeostasis in obese women.

Methods

A randomized double-blind placebo-controlled study was conducted with 16 women with obesity diagnosis and 8 women in the normal weight range. The obese volunteers were matched by age and body mass index and randomly assigned to either the placebo (3 g/day starch flour) or taurine (3 g/day taurine) group. The study lasted 8 weeks, and the experimental protocol included nutritional assessment and determination of plasma sulfur amino acids, insulin, and adiponectin, serum glycemia, and markers of inflammatory response and oxidative stress.

Results

Plasma taurine levels were significantly decreased (41 %) in the obese volunteers. Both the placebo and taurine groups showed significant reduction in weight (3 %), with no differences between groups. Different from placebo, taurine-supplemented group showed significant increase in plasma taurine (97 %) and adiponectin (12 %) and significant reduction in the inflammatory marker hs-C-reactive protein (29 %) and in the lipid peroxidation marker thiobarbituric acid reactive substances (TBARS) (20 %).

Conclusions

Eight weeks of taurine supplementation associated with nutritional counseling is able to increase adiponectin levels and to decrease markers of inflammation (high-sensitivity C-reactive protein) and lipid peroxidation (TBARS) in obese women.

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Acknowledgments

The authors acknowledge Gilberto João Padovan for technical support on taurine assay. This study was funded by the National Council of Scientific and Technological Development (CNPq) and the State of São Paulo Research Foundation (FAPESP).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, CEP 14049-900, Brazil

    Flávia Troncon Rosa, Alceu Afonso Jordão & Julio Sérgio Marchini

  2. School of Physical Education and Sports of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, CEP 14040-907, Brazil

    Ellen Cristini Freitas

  3. Institute of Physical Education and Sport, State University of Londrina, Rodovia Celso Garcia Cid, Pr 445 Km 380, Campus Universitário, Londrina, PR, CEP 86051-980, Brazil

    Rafael Deminice

Authors
  1. Flávia Troncon Rosa
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  2. Ellen Cristini Freitas
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  3. Rafael Deminice
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  4. Alceu Afonso Jordão
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  5. Julio Sérgio Marchini
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Correspondence to Flávia Troncon Rosa.

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Rosa, F.T., Freitas, E.C., Deminice, R. et al. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study. Eur J Nutr 53, 823–830 (2014). https://doi.org/10.1007/s00394-013-0586-7

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  • DOI: https://doi.org/10.1007/s00394-013-0586-7

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