The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women.
Materials and methods
A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76–1.42 μM) and 45 high (≥1.42 μM) urinary phytate concentrations. Densitometry values for neck were measured at enrollment and after 12 months (lumbar spine and femoral neck), and 10-year risk fracture was calculated using the tool FRAX®.
Individuals with low InsP6 levels had significantly greater bone mass loss in the lumbar spine (3.08 ± 0.65 % vs. 0.43 ± 0.55 %) than did those with high phytate levels. Moreover, a significantly greater percentage of women with low than with high InsP6 levels showed more than 2 % of bone mass loss in the lumbar spine (55.6 vs. 20.7 %). The 10-year fracture probability was also significantly higher in the low-phytate group compared to the high-phytate group, both in hip (0.37 ± 0.06 % vs 0.18 ± 0.04 %) and major osteoporotic fracture (2.45 ± 0.24 % vs 1.83 ± 0.11 %).
It can be concluded that high urinary phytate concentrations are correlated with reduced bone mass loss in lumbar spine over 12 months and with reduced 10-year probability of hip and major osteoporotic fracture, indicating that increased phytate consumption can prevent development of osteoporosis.
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Selective estrogen receptor modulators
US food and drug administration
Receptor activator for nuclear factor κ B ligand
Hormone replacement therapy
Myo-inositol hexaphosphate, phytate
Bone mineral density
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F.T. thanks the Ministerio de Ciencia e Innovación de España for a Torres Quevedo contract. This work was supported by the Conselleria d’Innovacio i Energia del Govern de les Illes Balears and by project grant no. CTQ2010-18271 from the Ministerio de Ciencia y Tecnologia de España.
Conflict of interest
F.G. and J.P. declare that they are inventors of a pending patent application based on some aspects of this work. F.T. is employee at Laboratoris Sanifit. J.P. is employee and stockholder at Laboratoris Sanifit.
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López-González, Á.A., Grases, F., Monroy, N. et al. Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women. Eur J Nutr 52, 717–726 (2013). https://doi.org/10.1007/s00394-012-0377-6
- Bone mass loss
- Bone mineral density
- Risk of fracture