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European Journal of Nutrition

, Volume 52, Issue 2, pp 513–525 | Cite as

Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health

  • Tuija Jääskeläinen
  • Paul KnektEmail author
  • Jukka Marniemi
  • Laura Sares-Jäske
  • Satu Männistö
  • Markku Heliövaara
  • Ritva Järvinen
Original Contribution

Abstract

Purpose

Low serum 25(OH)D concentration has been shown to predict the occurrence of several chronic diseases. It is, however, still unclear whether the associations are causal or due to confounding. The aim of this study was to investigate the associations between serum 25(OH)D concentration and sociodemographic, lifestyle and metabolic health-related factors.

Methods

The study population comprised 5,714 men and women, aged 30–79 years, from the Health 2000 Survey representing the Finnish population. Serum 25(OH)D concentration was determined by radioimmunoassay from serum samples frozen at −70 °C. Sociodemographic, lifestyle and metabolic factors were determined by questionnaires, interviews and measurements. Linear regression was used to assess the associations between serum 25(OH)D and the factors studied.

Results

The mean serum 25(OH)D concentration was 45.3 nmol/l and it varied between categories of sociodemographic, lifestyle and metabolic health variables. Older age, being married or cohabiting and higher education were related to higher serum 25(OH)D concentration. Those with the healthiest lifestyle estimated by a lifestyle index based on body mass index, physical activity, smoking, alcohol consumption and diet had 15.8 nmol/l higher serum 25(OH)D concentration compared to those with the unhealthiest lifestyle. Of the indicators of metabolic health, only waist circumference and HDL cholesterol were significantly associated with 25(OH)D after adjustment for sociodemographic, lifestyle and other metabolic health factors.

Conclusion

This study suggests that serum 25(OH)D concentration is associated with a multitude of sociodemographic, lifestyle and metabolic health factors. Thus, it is possible that such factors confound associations observed between serum 25(OH)D concentration and chronic diseases.

Keywords

Vitamin D status Serum 25(OH)D Sociodemographic factors Lifestyle Metabolic health Cross-sectional study 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Grant WB (2006) Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol 92:65–79CrossRefGoogle Scholar
  2. 2.
    Mattila C, Knekt P, Männistö S, Rissanen H, Laaksonen MA, Montonen J, Reunanen A (2007) Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 30:2569–2570CrossRefGoogle Scholar
  3. 3.
    Giovannucci E, Liu Y, Hollis BW, Rimm EB (2008) 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168:1174–1180CrossRefGoogle Scholar
  4. 4.
    Bertone-Johnson ER, Chen WY, Holick MF, Hollis BW, Colditz GA, Willett WC, Hankinson SE (2005) Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 14:1991–1997CrossRefGoogle Scholar
  5. 5.
    Kilkkinen A, Knekt P, Heliövaara M, Rissanen H, Marniemi J, Hakulinen T, Aromaa A (2008) Vitamin D status and the risk of lung cancer: a cohort study in Finland. Cancer Epidemiol Biomarkers Prev 17:3274–3278CrossRefGoogle Scholar
  6. 6.
    Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M (2010) Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67:808–811CrossRefGoogle Scholar
  7. 7.
    Maestro B, Campion J, Davila N, Calle C (2000) Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 47:383–391CrossRefGoogle Scholar
  8. 8.
    Cohen-Lahav M, Douvdevani A, Chaimovitz C, Shany S (2007) The anti-inflammatory activity of 1,25-dihydroxyvitamin D3 in macrophages. J Steroid Biochem Mol Biol 103:558–562CrossRefGoogle Scholar
  9. 9.
    DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80:1689S–1696SGoogle Scholar
  10. 10.
    Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110:229–238Google Scholar
  11. 11.
    Yang ES, Burnstein KL (2003) Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. J Biol Chem 278:46862–46868CrossRefGoogle Scholar
  12. 12.
    Newmark HL, Newmark J (2007) Vitamin D and Parkinson’s disease—a hypothesis. Mov Disord 22:461–468CrossRefGoogle Scholar
  13. 13.
    Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G (2010) Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromso study. Eur J Nutr 49:401–407CrossRefGoogle Scholar
  14. 14.
    Hintzpeter B, Mensink GB, Thierfelder W, Muller MJ, Scheidt-Nave C (2008) Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62:1079–1089CrossRefGoogle Scholar
  15. 15.
    Melamed ML, Michos ED, Post W, Astor B (2008) 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 168:1629–1637CrossRefGoogle Scholar
  16. 16.
    Scragg R, Camargo CA Jr (2008) Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 168:577–586CrossRefGoogle Scholar
  17. 17.
    Scragg R, Sowers M, Bell C (2007) Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 20:713–719CrossRefGoogle Scholar
  18. 18.
    Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G (2010) High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr 64:1457–1464CrossRefGoogle Scholar
  19. 19.
    Heistaro S (ed) (2008) Methodology report. Health 2000 Survey. National Public Health Institute, HelsinkiGoogle Scholar
  20. 20.
    Männistö S, Virtanen M, Mikkonen T, Pietinen P (1996) Reproducibility and validity of a food frequency questionnaire in a case-control study on breast cancer. J Clin Epidemiol 49:401–409CrossRefGoogle Scholar
  21. 21.
    Paalanen L, Männistö S, Virtanen MJ, Knekt P, Räsänen L, Montonen J, Pietinen P (2006) Validity of a food frequency questionnaire varied by age and body mass index. J Clin Epidemiol 59:994–1001CrossRefGoogle Scholar
  22. 22.
    Reinivuo H, Hirvonen T, Ovaskainen ML, Korhonen T, Valsta LM (2010) Dietary survey methodology of FINDIET 2007 with a risk assessment perspective. Public Health Nutr 13:915–919CrossRefGoogle Scholar
  23. 23.
    McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB, Spiegelman D, Hunter DJ, Colditz GA, Willett WC (2002) Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr 76:1261–1271Google Scholar
  24. 24.
    Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790–797CrossRefGoogle Scholar
  25. 25.
    Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645CrossRefGoogle Scholar
  26. 26.
    Searle S (1971) Linear models. Wiley, New YorkGoogle Scholar
  27. 27.
    Lee J (1981) Covariance adjustment of rates based on the multiple logistic regression model. J Chronic Dis 34:415–426CrossRefGoogle Scholar
  28. 28.
    Kimlin MG (2008) Geographic location and vitamin D synthesis. Mol Aspects Med 29:453–461CrossRefGoogle Scholar
  29. 29.
    MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–1538CrossRefGoogle Scholar
  30. 30.
    Montonen J, Männistö S, Sarkkola C, Järvinen R, Hakala P, Sääksjärvi K, Pietinen P, Reinivuo H, Korhonen T, Virtala E, Knekt P (2008) Socio-demographic differences in diet. Health 2000 Survey. National Public Health Institute, Finland, Helsinki (In Finnish with English summary)Google Scholar
  31. 31.
    Aromaa A, Koskinen S (eds) (2004) Health and functional capacity in Finland: Baseline Results of the Health 2000 Health Examination Survey. National Public Health Institute, HelsinkiGoogle Scholar
  32. 32.
    Joung IM, Stronks K, van de Mheen H, Mackenbach JP (1995) Health behaviours explain part of the differences in self reported health associated with partner/marital status in The Netherlands. J Epidemiol Community Health 49:482–488CrossRefGoogle Scholar
  33. 33.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690–693Google Scholar
  34. 34.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S (1985) Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 76:370–373CrossRefGoogle Scholar
  35. 35.
    Kamycheva E, Joakimsen RM, Jorde R (2003) Intakes of calcium and vitamin d predict body mass index in the population of Northern Norway. J Nutr 133:102–106Google Scholar
  36. 36.
    Looker AC (2007) Do body fat and exercise modulate vitamin D status? Nutr Rev 65:124–126CrossRefGoogle Scholar
  37. 37.
    Hirani V, Mosdol A, Mishra G (2009) Predictors of 25-hydroxyvitamin D status among adults in two British national surveys. Br J Nutr 101:760–764CrossRefGoogle Scholar
  38. 38.
    Brock K, Huang WY, Fraser DR, Ke L, Tseng M, Stolzenberg-Solomon R, Peters U, Ahn J, Purdue M, Mason RS, McCarty C, Ziegler RG, Graubard B (2010) Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J Steroid Biochem Mol Biol 121:462–466CrossRefGoogle Scholar
  39. 39.
    Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC (1996) Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 275:447–451CrossRefGoogle Scholar
  40. 40.
    Montonen J, Knekt P, Järvinen R, Aromaa A, Reunanen A (2003) Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 77:622–629Google Scholar
  41. 41.
    Shi H, Norman AW, Okamura WH, Sen A, Zemel MB (2001) 1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J 15:2751–2753Google Scholar
  42. 42.
    Holick MF (2009) Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 19:73–78CrossRefGoogle Scholar
  43. 43.
    Platz EA, Leitzmann MF, Hollis BW, Willett WC, Giovannucci E (2004) Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer. Cancer Causes Control 15:255–265CrossRefGoogle Scholar
  44. 44.
    Lips P, Chapuy MC, Dawson-Hughes B, Pols HA, Holick MF (1999) An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos Int 9:394–397CrossRefGoogle Scholar
  45. 45.
    Antoniucci DM, Black DM, Sellmeyer DE (2005) Serum 25-hydroxyvitamin D is unaffected by multiple freeze-thaw cycles. Clin Chem 51:258–261CrossRefGoogle Scholar
  46. 46.
    Ockè MC, Schrijver J, Obermann-de Boer GL, Bloemberg BP, Haenen GR, Kromhout D (1995) Stability of blood (pro)vitamins during four years of storage at -20 degrees C: consequences for epidemiologic research. J Clin Epidemiol 48:1077–1085CrossRefGoogle Scholar
  47. 47.
    Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA (2008) Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004. Am J Clin Nutr 88:1519–1527CrossRefGoogle Scholar
  48. 48.
    Langlois K, Greene-Finestone L, Little J, Hidiroglou N, Whiting S (2010) Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Rep 21:47–55Google Scholar
  49. 49.
    McGrath JJ, Saha S, Burne TH, Eyles DW (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 121:471–477CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Tuija Jääskeläinen
    • 1
  • Paul Knekt
    • 1
    Email author
  • Jukka Marniemi
    • 2
  • Laura Sares-Jäske
    • 1
  • Satu Männistö
    • 1
  • Markku Heliövaara
    • 1
  • Ritva Järvinen
    • 3
  1. 1.National Institute for Health and WelfareHelsinkiFinland
  2. 2.National Institute for Health and WelfareTurkuFinland
  3. 3.University of Eastern FinlandKuopioFinland

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