New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
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A metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. This study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated from the herb curcuma longa, known to possess anti-inflammatory activities. However, little is known about its exact underlying molecular mechanisms in the treatment of obesity and metabolic diseases. Furthermore, cell cultures, animal models of obesity, and few human clinical and epidemiological studies have added the promise for future therapeutic interventions of this dietary compound.
An electronic search was performed using Science finder, Medline, Scopus, Google scholar and collected English language articles from 2000 to 2010, relating to the role of curcumin in obesity and metabolic diseases.
Obesity has been classified as a growing epidemic and its associated metabolic disorders are considered a major risk to the health system. Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/β-catenin and activates PPAR-γ, Nrf2 cell signaling pathway. In addition, curcumin downregulates the inflammatory cytokines, resistin and leptin, and upregulates adiponectin as well as other associated proteins. The interactions of curcumin with several signal transduction pathways reverse insulin resistance, hyperglycemia, hyperlipidemia, and other inflammatory symptoms associated with obesity and metabolic diseases.
The modulation of several cellular transduction pathways by curcumin has recently been extended to elucidate the molecular basis for obesity and obesity-related metabolic diseases. These findings might enable novel phytochemical treatment strategies as well as curcumin translation to the clinical practice for the treatment and prevention of obesity-related chronic diseases. Furthermore, the relatively low cost of curcumin, safety and proven efficacy make it advisable to include curcumin as part of healthy diet.
KeywordsCurcumin Obesity Inflammation Adipocytes Adiponectin
This work was supported by Nuclear Research and Development Program of National Research Foundation of Korea funded by Ministry of Education, Science and Technology (grant code: 2010-0017517).
- 1.DC C (2005) State-specific prevalence of obesity among adults—United States. MMWR 55:985–988Google Scholar
- 2.Health Survey for England (2007) http://www.ic.nhs.uk/statistics-and-datacollections/health-and-lifestyles-related-surveys/health-survey-forengland/health-survey for england-2007-latest-trends-%5Bns%5D
- 4.Spiegelman BM, Flier JS (2001)Obesity and the regulation of energy balance. Cell 104(4):531–543Google Scholar
- 5.Friedman JM (2000) Obesity in the new millennium. Nature 404(6778):632–634Google Scholar
- 6.Barsh GS, Farooqi IS, O’Rahilly S (2000) Genetics of body-weight regulation. Nature 404(6778):644–651Google Scholar
- 7.Luchsinger JA (2006) A work in progress: the metabolic syndrome. Sci Aging Knowl Environ (10):pe19Google Scholar
- 9.IARC handbooks of cancer prevention (2002) Weight control and physical activity, international agency for research on cancer, Lyon. France 6:1–315Google Scholar
- 10.Shehzad A, Lee YS (2010) Curcumin: multiple molecular targets mediate multiple pharmacological actions. Drugs Future 35(2):113–119Google Scholar
- 17.Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN (2010) Regulation of adiponectin production by insulin: Interactions with tumor necrosis factor-alpha and interleukin-6. Am J Physiol Endocrinol Metab, doi: 10.1152/ajpendo.00307
- 26.Shoelson SE, Lee J, Yuan M (2003) Inflammation and the IKKβ/Iκβ/NF-κB axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord (Suppl 3):S49–S52Google Scholar
- 31.Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson RS, Rosenfeld MG, Glass CK (2004) A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci USA 101(40):14461–14466CrossRefGoogle Scholar
- 35.Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821–1830Google Scholar
- 38.Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S (2006) Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc 34(1–2):109–115Google Scholar
- 39.Woo HM, Kang JH, Kawada T, Yoo H, Sung MK, Yu R (2007) Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci 80(10):926–931CrossRefGoogle Scholar
- 42.Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T (2001) Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr 131(8):2090–2095Google Scholar
- 60.Karthikesan K, Pari L, Menon VP (2010) Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys 29(1):23–30Google Scholar
- 62.Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K (2008) The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 118(3):868–878Google Scholar
- 71.Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S (2008) The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 40(4):201–210Google Scholar
- 73.Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N (2008) Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D 9(4):243–250CrossRefGoogle Scholar
- 75.Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G (2010) Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 52(2 Suppl 1):55–62Google Scholar
- 76.Allegri P, Mastromarino A, Neri P (2010) Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol 4:1201–1206Google Scholar
- 78.Evaluation of Certain Food Additives (2000) WHO technical report series. WHO, Geneva, p 891Google Scholar