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Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection


Background & Aims

The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infected patients was examined.


Dietary record and blood levels of B vitamins and oxidative stress–associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV patients.


HBV-infected patients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients had significantly higher Ishak inflammation score and lactate dehydrogenase activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC) vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2 and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity (p < 0.05), but HCV patients had significantly lower superoxide dismutase and catalase activities (p < 0.05).


HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infected patients.

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Fig. 1



Alanine aminotransferase


Aspartate aminotransferase


Glutathione peroxidase




Oxidized glutathione




Hepatitis B virus


Hepatitis C virus


High density lipoprotein


Lactate dehydrogenase


Low density lipoprotein




Superoxide dismutase


Xanthine oxidase


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Authors, Lin CC, Liu WH, Wang ZH and Yin MC, would like to thank all subjects participated in this study.

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Correspondence to Mei-chin Yin.

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Lin, Cc., Liu, Wh., Wang, Zh. et al. Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection. Eur J Nutr 50, 499–506 (2011).

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