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ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe–Diet Attica Investigation on childhood obesity

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Abstract

Background

Adiponectin, an adipose-derived hormone with central and peripheral actions, is involved in the regulation of energy homeostasis. Interactions between genetic and environmental factors have been associated with decrease in circulating adiponectin leading to obesity.

Aim

We investigated whether variants of the ADIPOQ gene encoding adiponectin interact with diet to predict serum adiponectin concentration.

Methods

A cross-sectional study of healthy school-aged children of Greek origin (n = 991), aged 11.2 ± 0.6 years was conducted in 2005–2006. DNA was genotyped for two SNPs [rs1501299 (n = 741) and rs17300539 (n = 713)] located in the ADIPOQ gene. Detailed dietary, behavioural, lifestyle, anthropometric and biochemical data were recorded for all participants.

Results

Both SNPs were in HWE. The rs1501299 (GG vs GT + TT) × fibre interaction was significantly associated with adiponectin concentration (P = 0.028). When fibre intake was low, GG homozygotes exhibited significantly higher adiponectin concentrations compared to T allele carriers (mean ± SD = 5.1 ± 2.7 vs 4.2 ± 2.3; P = 0.020).

Conclusions

In the present study, the rs1501299 × fibre interaction was significantly associated with adiponectin levels; in specific, GG homozygotes exhibited higher adiponectin levels compared to T carriers under conditions of lower fibre intake.

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Fig. 1

Abbreviations

BMI:

Body mass index

SNP:

Single nucleotide polymorphism

AMPK:

AMP-activated protein kinase

PUFA:

Polyunsaturated fatty acid

CVD:

Cardiovascular disease

EI:

Energy intake

BMR:

Basal metabolic rate

HWE:

Hardy–Weinberg equilibrium

SD:

Standard deviation

MET:

Metabolic cost of activity

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Acknowledgments

We would like to acknowledge Ioannis Alexandrou, Nektarios Lainakis, as well as all the undergraduate nutrition students, for their excellent assistance during data collection and management. This study was partially supported by a research grant from Coca-Cola Hellas. Melissa C. Smart was supported by a Unilever/BBSRC case studentship and Philippa J. Talmud was supported by the British Heart Foundation (PG2005/014).

Conflict of interest statement

We declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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Authors and Affiliations

  1. Department of Dietetics, Nutrition, Harokopio University, 70 El. Venizelou St., 17671, Athens, Greece

    Ioanna Ntalla, George Dedoussis, Mary Yannakoulia, Eirini Louizou & Constantina Papoutsakis

  2. Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK

    Melissa C. Smart & Philippa J. Talmud

  3. First Pediatric Department, Athens University Medical Clinic School, Athens, Greece

    Sophia D. Sakka

Authors
  1. Ioanna Ntalla
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  2. George Dedoussis
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  3. Mary Yannakoulia
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  4. Melissa C. Smart
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  5. Eirini Louizou
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  6. Sophia D. Sakka
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  7. Constantina Papoutsakis
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  8. Philippa J. Talmud
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Corresponding author

Correspondence to George Dedoussis.

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Ntalla, I., Dedoussis, G., Yannakoulia, M. et al. ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe–Diet Attica Investigation on childhood obesity. Eur J Nutr 48, 493–497 (2009). https://doi.org/10.1007/s00394-009-0034-x

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  • DOI: https://doi.org/10.1007/s00394-009-0034-x

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