Early infant feeding and type 1 diabetes
- 508 Downloads
Infant feeding practices, particularly the type of milk feeding, have been associated with the development of type 1 diabetes.
Aim of the study
We studied the relationship between early infant feeding (during the first year of life) and diabetes in a large population-based cohort.
In 1994–1995, 6,209 healthy full-term newborns participated in a study examining the effect of supplementary feeding, on development of allergy to cow’s milk, in maternity hospitals. All supplements in the maternity hospitals were known. Mothers recorded the feeding of infants prospectively at home. In August 2006, from a nationwide diabetes registry, 45 children from our cohort were listed as having type 1 diabetes.
The distribution of cases was similar in the randomized feeding groups: 9/1,789 in the group that received adapted cow’s milk-based formula; 12/1,737 in those who received extensively hydrolyzed formula; 16/1,859 in those who received banked human milk; and 8 among those 824 exclusively breast-fed in the hospital. When children who had received cow’s milk-based formula in the maternity hospital were compared with those without such exposure, less number of children in the former group had diabetes by age 8 (P = 0.026), but by the end of the follow-up (11.5 years) the difference disappeared (P = 0.16). Length of breast-feeding and introduction of cereals and other solid foods were similar among those developing type 1 diabetes and those remaining healthy, while early regular daily feeding with cow’s milk-based formula tended to associate with lower risk for type 1 diabetes (OR 0.66; 95% confidence interval 0.38–1.13; P = 0.08).
In an extended, secondary analysis of a population-based cohort, very early exposure to cow’s milk is not a risk factor for type 1 diabetes; it may in fact diminish its appearance before age 8.
KeywordsType 1 diabetes Infant feeding Breast milk Infant formula
We thank Professor Seppo Sarna for his advice on survival analysis. Fund support was from the Sigrid Juselius Foundation and State Special Funds for Research at the University Central Hospital, Helsinki (EVO).
- 1.Akerblom HK, Virtanen SM, Ilonen J, Savilahti E, Vaarala O, Reunanen A, Teramo K, Hämäläinen AM, Paronen J, Riikjarv MA, Ormisson A, Ludvigsson J, Dosch HM, Hakulinen T, Knip M (2005) Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study. Diabetologia 48:829–837CrossRefGoogle Scholar
- 7.Hasunen K, Ryynänen S (2006) Infant feeding in Finland 2005. Reports of the Ministry of Social Affairs and Health, vol 19, pp 1–70Google Scholar
- 8.Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel DB, Steiner L, Walker K, Shult P, Gangnon RE, Gern JE, Martinez FD, Lemanske RF, Ober C (2005) Gene–environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet 76:696–704CrossRefGoogle Scholar
- 21.Saukkonen T, Virtanen SM, Karppinen M, Reijonen H, Ilonen J, Räsänen L, Åkerblom HK, Savilahti E (1998) Significance of cow’s milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow’s milk intake and HLA-DQB1 genotype: Childhood Diabetes in Finland Study Group. Diabetologia 41:72–78CrossRefGoogle Scholar
- 25.Virtanen SM, Räsänen L, Ylönen K, Aro A, Clayton D, Langholz B, Pitkäniemi J, Savilahti E, Lounamaa R, Tuomilehto J, Åkerblom HK (1993) Early introduction of dairy products is associated with increased risk of insulin-dependent diabetes mellitus in Finnish children. Diabetes 42:1786–1790CrossRefGoogle Scholar
- 26.Virtanen SM, Kenward MG, Erkkola M, Kautiainen S, Kronberg-Kippila C, Hakulinen T, Ahonen S, Uusitalo L, Niinisto S, Veijola R, Simell O, Ilonen J, Knip M (2006) Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 49:1512–1521CrossRefGoogle Scholar