Lack of oxidative stress in a selenium deficient area in Ivory Coast
- 91 Downloads
Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast.
Aim of the study
To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region).
This study involved 57 subjects, 18 to 69 years old, living in the Glanle region and 56 healthy controls living in the southern coastal region (Bodou). In the Glanle region families consume basically a vegetarian and crude palm oil diet, whereas in the Bodou region, families eat a fish–based diet with principally refined palm oil. Fasting blood samples were collected to assess the following parameters: lipid status (plasma total lipids; total–, HDL and LDL–cholesterol; triglycerides; phospholipids; fatty acid composition), plasma protein status (total protein, albumin, transthyretin, orosomucoid, CRP, transferrin), antioxidant capacity (plasma selenium, uric acid, retinol, α–tocopherol and tocotrienols levels, plasma seleno–glutathione peroxidase (GSHPx) activity) and oxidative stress markers (malondialdehyde (MDA) and advanced oxidation protein products (AOPP)).
The mountain region samples (Glanle) were characterized by significantly lower plasma albumin, total–, HDL– and LDL–cholesterol, retinol and selenium levels, plasma PUFA content and GSHPx activity, but significantly higher alpha–tocopherol index and total tocotrienol level, than controls from the coastal area (Bodou). These results suggest a higher exposure risk to oxidative stress for the mountain region subjects. However, the absence of oxidative damage in this group provides evidence of a selenium independent protection mechanism against oxidative stress. This protection is related to lower plasma LDL cholesterol and PUFA content, and to higher α–tocopherol index, δ and total tocotrienols.
The long–term consumption of crude palm oil could be considered as an effective protective factor against oxidative stress.
Key wordsoxidative stress selenium palm oil Ivory Coast
Unable to display preview. Download preview PDF.
- 1.Betteridge DJ (2000) What is oxidative stress? Metabolism 49:3–4Google Scholar
- 7.Chen X, Jang G, Chen X, Wen Z, Ge K (1980) Studies on the relationship of selenium and Keshan disease. Biol Trace Elem Res 2:91–107Google Scholar
- 9.Kouame P (2000) Approche épidémiologique et anthropologique d’une population exposée à la carence en iode: exemple de Glanle en Côte d’Ivoire. University Thesis, BordeauxGoogle Scholar
- 10.Arnaud J, Malvy D, Richard MJ, Faure H, Chaventre A (2001) Selenium status in a deficient population of the west Ivory Coast. J Physiol Anthropo 20(2):81–84Google Scholar
- 11.WHO (World Health organization) (1995) Physical status: the use and interpretation of anthropometry. Geneva: WHO Technical Report SeriesGoogle Scholar
- 17.Witko-Sarsat V, Friedlande M, Capeillere-Blandin C, Nguyen-Koa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latsha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 45:1304–1313Google Scholar
- 20.Schemann J-F, Banou AA, Guindo A, Joret V, Traore L, Malvy D (2002) Prevalence of undernutrition and vitamin A deficiency in the Dogon region, Mali. J Am Coll Nutr 5:381–387Google Scholar
- 21.Tiahou G (1994) Evaluation du taux sérique de la lipoprotéine (a) chez l’ivoirien sain: dosage par immunonéphélémétrie. University Thesis, Abidjan. N° 1583Google Scholar
- 25.Glueck CJ, Kelley W, Gupta A, Fontaine RN, Wang P, Gartside PS (1997) Prospective 10 years evaluation of hypocholesterolemia in cohort of 772 firefighters and cross-sectional evaluation of hypocholesterolemia in 1479 men in the national health and nutrition examination survey. I Metabolism 6:625–633CrossRefGoogle Scholar
- 28.Hayes KC, Khosla P (1992) Dietary fatty acid thresholds and cholesterolemia FASEB J 6:2600–2607Google Scholar
- 30.Qureshi AA, Qureshi N, Wright JJK, et al. (1991a) Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am J Clin Nutr 53:1021s–1026sGoogle Scholar
- 31.Qureshi AA, Qureshi N, Hasler-Rapacz JO, et al. (1991b) Dietary tocotrienols reduce concentration of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. Am J Clin Nutr 53:1042s–1046sGoogle Scholar
- 35.Pauletto P, Puato M, Angeli MT, Pessiana AC, et al. (1996) Blood pressure, serum lipids, and fatty acids in a lakefish diet or on a vegetarian diet in Tanzania. Lipids 31:309s–312sGoogle Scholar
- 36.Adams-Campbell LL, Nwankwo MU, Ukoli FA, Omene JA, Kuller LH (1992) Serum retinol, carotenoid, vitamin E, and cholesterol in Nigerian women. J Nut Biochem 3:58–61Google Scholar
- 37.Gouado I, Mbiappo TF, Moundipa FP, Teugwa M (1998) Vitamine A and E status of some rural populations in the north of Cameroon. Int J Vit Nutr 68:21–25Google Scholar
- 38.Traber MG, Lane JC, Lagmay NR, Kayden HJ (1992) Studies on the transfer of tocopherol between lipoproteins. Lipids 27:659–663Google Scholar
- 40.Hayes KC, Pronczuk A, Liang JS (1993) Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters. Proc Soc Exp Biol Med 202–203Google Scholar
- 41.Noguchi N, Hanyu R, Nonaka A, Okimoto Y, Kodama T (2003) Inhibition of THP-1 cell adhesion to endothelial cells by alpha tocopherol and alpha tocotrienol is dependent on intracellular concentration of the antioxidants. Free Rad Biol Med 35 (in press)Google Scholar