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Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults

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Summary.

Background:

High intake of soy products has been suggested to prevent breast cancer, osteoporosis, and cardiovascular diseases.

Aim of the study:

To investigate the effects of isoflavone-containing soy on circulating sex hormones, biomarkers of bone turnover, and lipoprotein profiles.

Methods:

Fourteen young women received in a randomized crossover design 5 soy cookies (52 mg isoflavones) or 5 soy-free cookies (no isoflavones) per day for one menstrual cycle starting one week before menstruation. Serum and urine analyses were performed on day 3 after onset of menstruation (t1), 3 days before ovulation (t2), 3 days after ovulation (t3), during the midluteal phase (t4), and again 3 days after onset of the next menstruation (t5).

Results:

With the exception of higher progesterone levels at t2, soy supplementation did not affect the physiologic fluctuations in circulating sex hormones. The ratio of C-telopeptide (a bone resorption marker) to osteocalcin (a bone formation marker) was slightly higher at t4 during the soy period compared to t4 during the control period (P < 0.05), indicating an uncoupling of bone resorption and formation processes. Serum levels of total cholesterol, LDL cholesterol, and HDL cholesterol were not influenced by soy intake.

Conclusions:

High short-term isoflavone-containing soy intake slightly affects physiologic fluctuations in bone turnover, but has no significant effects on most circulating sex hormones and on lipoprotein parameters in young healthy women.

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Correspondence to Armin Zittermann PhD.

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Zittermann, A., Geppert, J., Baier, S. et al. Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults. Eur J Nutr 43, 100–108 (2004). https://doi.org/10.1007/s00394-004-0447-5

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  • DOI: https://doi.org/10.1007/s00394-004-0447-5

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