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Speicheldrüsenschwellung und Sicca-Symptomatik bei Morbus Kimura, einer seltenen rheumatologischen Differenzialdiagnose mit wegweisend hohem IgE-Serumspiegel – eine aktuelle Übersicht nach Literatursuche

Swelling of the salivary glands and sicca symptoms in Kimuraʼs disease, a rare rheumatological differential diagnosis with an indicatively high IgE serum level—A current overview after literature search

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Zusammenfassung

Rheumatische Erkrankungen des Bewegungsapparats umfassen verschiedene Erkrankungen mit zum Teil sehr unterschiedlichen Symptomen, von denen einige lokal begrenzt sind und andere systemische Merkmale aufweisen. Autoimmunphänomene wie z. B. beim Sjögren-Syndrom verursachen oft Symptome wie Xerostomie und Xerophthalmie im Zusammenhang mit Entzündungen in den Speicheldrüsen. Die Pathogenese dieser Erkrankungen ist nur zum Teil geklärt. Ähnlich verhält es sich mit allergischen Erkrankungen, die sich bezüglich der Symptome und Pathomechanismen sonst deutlich unterscheiden, aber auch hier können selten Schwellungen der Speicheldrüsen auftreten. Da es sich um eine mögliche Differenzialdiagnose des Sjögren-Syndroms oder auch von IgG4-assoziierten Erkrankungen handelt und ein solcher Fall kürzlich beschrieben wurde, wurde eine Literatursuche in PubMed gemacht, deren Ergebnisse hier präsentiert und in einer kurzen Übersicht im Folgenden zusammengestellt werden.

Abstract

Rheumatic and musculoskeletal diseases (RMD) include various diseases with sometimes rather different symptoms, some of which are locally confined and others show systemic features. Autoimmune phenomena, such as those occurring in Sjögrenʼs syndrome, often cause symptoms such as xerostomia and xerophthalmia in association with inflammation of the salivary glands. The pathogenesis of these diseases is only partly clarified. This is similar to allergic diseases, which are otherwise clearly different with respect to the symptoms and pathomechanisms but swelling of the salivary glands can also rarely occur here. As this is a possible differential diagnosis of Sjögrenʼs syndrome or also IgG4-associated diseases, and such a case was recently described, a literature search was carried out in PubMed, the results of which are presented here and summarized in this article in a brief overview.

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Literatur

  1. Knopf A, Bas M, Chaker A, Strassen U, Pickhard A, Stark T, Lahmer T, Thürmel K (2011) Rheumatic disorders affecting the head and neck: underestimated diseases. Rheumatology 50(11):2029–2034

    Article  PubMed  Google Scholar 

  2. Baldini C, Pepe P, Quartuccio L, Priori R, Bartoloni E, Alunno A, Gattamelata A, Maset M, Modesti M, Tavoni A, De Vita S, Gerli R, Valesini G, Bombardieri S (2014) Primary Sjögren’s syndrome as a multi-organ disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients. Rheumatology 53(5):839–844

    Article  PubMed  Google Scholar 

  3. Goules AV, Tzioufas AG (2017) Primary Sjögren’s syndrome: clinical phenotypes, outcome and the development of biomarkers. Immunol Res 65(1):331–344

    Article  CAS  PubMed  Google Scholar 

  4. Yamamoto M, Harada S, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, Takahashi H, Imai K (2005) Clinical and pathological differences between Mikulicz’s disease and Sjögren’s syndrome. Rheumatology 44(2):227–234

    Article  CAS  PubMed  Google Scholar 

  5. Kamisawa T, Zen Y, Pillai S, Stone JH (2015) IgG4-related disease. Lancet 385(9976):1460–1471

    Article  CAS  PubMed  Google Scholar 

  6. ACR/EULAR IgG4-RD Classification Criteria Committee, Wallace ZS, Zhang Y, Perugino CA, Naden R, Choi HK, Stone JH (2019) Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts. Ann Rheum Dis 78(3):406–412

    Article  Google Scholar 

  7. James DG, Sharma OP (2000) Parotid gland sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 17(1):27–32

    CAS  PubMed  Google Scholar 

  8. Aravinthan M, Atukorala I, De Silva C (2022) A diagnostic conundrum; Kimura’s disease mimicking eosinophilic granulomatosis with polyangiitis. SAGE Open Med. https://doi.org/10.1177/2050313X211070522

    Article  Google Scholar 

  9. Braun J, Mairinger T, Kaschke O, Behrend K, Ramsbacher J, Karberg K (2023) Bilateral swelling of the salivary glands and sicca symptoms—an unusual differential diagnosis: Kimura’s disease, a rare allergic condition with a high IgE serum level—a case report and review of the literature. RMD. https://doi.org/10.1136/rmdopen-2023-003135 (in press)

    Article  Google Scholar 

  10. Sah P, Kamath A, Aramanadka C, Radhakrishnan R (2013) Kimura’s disease—An unusual presentation involving subcutaneous tissue, parotid gland and lymph node. J Oral Maxillofac Pathol 17(3):455–459

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kim HT (1937) Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz’s disease. Chin Med J 23:699–670

    Google Scholar 

  12. Kimura T, Yoshimura S, Ishikawa E (1948) Unusual granulation combined with hyperplastic changes of lymphatic tissue. Trans Soc Pathol Jpn 37:179–180

    Google Scholar 

  13. Mai Y, Wang Y, Sun P, Jing Z, Dong P, Liu J (2023) Kimura disease in children: a report of 11 cases and review of the literature. Front Pediatr 11:1131963

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zhang Y, Bao H, Zhang X, Yang F, Liu Y, Li H, Lu J, Liu Y (2022) Kimura’s disease: clinical characteristics, management and outcome of 20 cases from China. Clin Exp Rheumatol 40(3):532–538

    Article  PubMed  Google Scholar 

  15. Rael EL, Marshall RT, McClain JJ (2012) The hyper-IgE syndromes: lessons in nature, from bench to bedside. World Allergy Organ J 5(7):79–87

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Kim WJ, Kim HK (2022) Current concepts of Kimura disease: pathophysiology and evolution of treatment. Arch Craniofac Surg 23(6):249–255

    Article  PubMed  PubMed Central  Google Scholar 

  17. Sjögren H (1933) Zur Kenntnis der keratoconjunctivitis sicca. Keratitis filiformis bei Hypo-funktion der Tränendrüsen. Acta Ophthalmol 2:1–151

    Google Scholar 

  18. Chisholm DM, Mason DK (1968) Labial salivary gland biopsy in Sjögren’s disease. J Clin Pathol 21(5):656–660

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X, International Sjögren’s Syndrome Criteria Working Group (2017) 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for primary Sjögren’s syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 76(1):9–16

    Article  PubMed  Google Scholar 

  20. Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH, American College of Rheumatology, European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group (2020) The 2019 ACR/EULAR classification criteria for IgG4-related disease. Arthritis Rheumatol 72(1):7–19

    Article  PubMed  Google Scholar 

  21. Zhu WX, Zhang YY, Sun ZP, Gao Y, Chen Y, Yu GY (2021) Differential diagnosis of immune-globulin G4-related sialadenitis and Kimura’s disease of the salivary gland: a comparative case series. Int J Oral Maxillofac Surg 50(7):895–905

    Article  PubMed  Google Scholar 

  22. Kimura Y, Pawankar R, Aoki M, Niimi Y, Kawana S (2002) Mast cells and T cells in Kimura’s disease express increased levels of interleukin‑4, interleukin‑5, eotaxin and RANTES. Clin Exp Allergy 32(12):1787–1793 (Erratum in: Clin Exp Allergy 2003 Apr; 33(4): 538)

    Article  CAS  PubMed  Google Scholar 

  23. Maehara T, Munemura R, Shimizu M, Kakizoe N, Kaneko N, Murakami Y, Masafumi M, Kiyoshima T, Kawano S, Nakamura S (2019) Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: a case report. Medicine 98(50):e18300

    Article  PubMed  PubMed Central  Google Scholar 

  24. Munemura R, Maehara T, Murakami Y, Koga R, Aoyagi R, Kaneko N, Doi A, Perugino CA, Della-Torre E, Saeki T, Sato Y, Yamamoto H, Kiyoshima T, Stone JH, Pillai S, Nakamura S (2022) Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease. J Allergy Clin Immunol 150(2):440–455.e17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Chen H, Thompson LD, Aguilera NS, Abbondanzo SL (2004) Kimura disease: a clinicopatho-logic study of 21 cases. Am J Surg Pathol 28(4):505–513

    Article  PubMed  Google Scholar 

  26. Zhang G, Li X, Sun G, Cao Y, Gao N, Qi W (2020) Clinical analysis of Kimura’s disease in 24 cases from China. BMC Surg 20(1):1

    Article  PubMed  PubMed Central  Google Scholar 

  27. Zhuang S, Chen X, Chen W, Li C, Wang T, Lin Q, Wang D (2022) A retrospective study of 20 patients with Kimura’s disease from China. Acta Otolaryngol 142(3–4):357–362

    Article  CAS  PubMed  Google Scholar 

  28. Lee CC, Yu KH, Chan TM (2022) Kimura’s disease: a clinicopathological study of 23 cases. Front Med 9:1069102

    Article  Google Scholar 

  29. Sangwan A, Goyal A, Bhalla AS, Kumar A, Sharma R, Arava S, Dawar R (2022) Kimura disease: a case series and systematic review of clinico-radiological features. Curr Probl Diagn Radiol 51(1):130–142

    Article  PubMed  Google Scholar 

  30. Wang J, Tang Z, Feng X, Zeng W, Tang W, Wu L, Jin L (2014) Preliminary study of diffusion-weighted imaging and magnetic resonance spectroscopy imaging in Kimura disease. J Craniofac Surg 25(6):2147–2151

    Article  PubMed  Google Scholar 

  31. Zhang R, Ban XH, Mo YX, Lv MM, Duan XH, Shen J, Li JP, Liu XW, Xie CM (2011) Kimura’s disease: the CT and MRI characteristics in fifteen cases. Eur J Radiol 80(2):489–497

    Article  PubMed  Google Scholar 

  32. Gopinathan A, Tan TY (2009) Kimura’s disease: imaging patterns on computed tomography. Clin Radiol 64(10):994–999

    Article  PubMed  Google Scholar 

  33. Shahrul H, Baharudin A, Effat O (2007) Kimura’s disease in Malay patients. Med J Malaysia 62(3):263–264

    CAS  PubMed  Google Scholar 

  34. Chew YK, Noorizan Y, Khir A, Brito-Mutunayagam S (2007) Parotid mass: a 5-year review of parotid surgery. Med J Malaysia 62(5):388–389

    CAS  PubMed  Google Scholar 

  35. Iwai H, Nakae K, Ikeda K, Ogura M, Miyamoto M, Omae M, Kaneko T, Yamashita T (2007) Kimura disease: diagnosis and prognostic factors. Otolaryngol Head Neck Surg 137(2):306–311

    Article  PubMed  Google Scholar 

  36. Gao Y, Chen Y, Yu GY (2006) Clinicopathologic study of parotid involvement in 21 cases of eosinophilic hyperplastic lymphogranuloma (Kimura’s disease). Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102(5):651–658

    Article  PubMed  Google Scholar 

  37. Madhavan M, Othman NH, Singh MS, Indudharan R, Sharma HS, Shamsuddin AR (2000) Kimura’s disease: a report of three cases with a brief review of literature. Acta Otorhinolaryngol Ital 20(4):284–289

    CAS  PubMed  Google Scholar 

  38. Li TJ, Chen XM, Wang SZ, Fan MW, Semba I, Kitano M (1996) Kimura’s disease: a clinicopathologic study of 54 Chinese patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82(5):549–555

    Article  CAS  PubMed  Google Scholar 

  39. Chow LT, Yuen RW, Tsui WM, Ma TK, Chow WH, Chan SK (1994) Cytologic features of Kimura’s disease in fine-needle aspirates. A study of eight cases. Am J Clin Pathol 102(3):316–321

    Article  CAS  PubMed  Google Scholar 

  40. Lee CY, Su CY, Sheen-Chen SM, Eng HL, Chen WJ (1994) Kimura’s disease—report of four cases. Changgeng Yi Xue Za Zhi 17(2):153–157

    CAS  PubMed  Google Scholar 

  41. Chan JK, Hui PK, Ng CS, Yuen NW, Kung IT, Gwi E (1989) Epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia) and Kimura’s disease in Chinese. Histopathology 15(6):557–574

    Article  CAS  PubMed  Google Scholar 

  42. Kung IT, Gibson JB, Bannatyne PM (1984) Kimura’s disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology 16(1):39–44

    Article  CAS  PubMed  Google Scholar 

  43. Tham KT, Leung PC, Saw D, Gwi E (1981) Kimura’s disease with salivary gland involvement. Br J Surg 68(7):495–497

    Article  CAS  PubMed  Google Scholar 

  44. Almazyad A, Al Khudiri N, Alshieban SS, Pharaon MM (2023) Concurrent Warthin tumor and Kimura disease: a case report. J Med Case Rep 17(1):7

    Article  PubMed  PubMed Central  Google Scholar 

  45. Hu X, Li X, Yang C, Li D, Cai J, Wang P (2022) Kimura disease, a rare cause of inguinal lymphadenopathy: a case report. Front Med 9:1023804

    Article  Google Scholar 

  46. Teco-Cortes JA, Navarrete-Pérez JJ, Sánchez-Castro OE (2022) Enfermedad de Kimura simulando neoplasia primaria de glándula parótida: Reporte de caso [Kimura’s disease mimicking primary neoplasm of the parotid gland: A case report]. Rev Med Inst Mex Seguro Soc 60(4):460–465

    PubMed  PubMed Central  Google Scholar 

  47. Li W (2022) Kimura’s disease in soft palate with clinical and histopathological presentation: a case report. World J Clin Cases 10(12):3842–3848

    Article  PubMed  PubMed Central  Google Scholar 

  48. Yang B, Liao H, Wang M, Long Q, Zhong H, Luo L, Liu Z, Cheng X (2022) Kimura’s disease successively affecting multiple body parts: a case-based literature review. BMC Ophthalmol 22(1):154

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Hanafiah M, Misni MN, Kimura Disease MNA (2022) A rare cause of head and neck tumour in children—a case report. Curr Med Imaging 18(4):436–439

    Article  PubMed  Google Scholar 

  50. Xie F, Kou Y, Zhang S, Shi L, Han J, Zhou X (2021) Bilateral posterior auricular masses: a case of Kimura’s disease. Ear Nose Throat J 100(9):634–637

    Article  PubMed  Google Scholar 

  51. Ong HY, Esa ME, Ng JJ, Wahab SA, Kalimuthu S (2022) Kimura’s disease with bilateral parotid involvement: a common presentation with an uncommon diagnosis. Braz J Otorhinolaryngol 88(Suppl 4):S219–S222

    Article  PubMed  Google Scholar 

  52. Sinai Khandeparkar SG, Aphale V, Bharti N, Gogate BP, Solanke S (2021) A rare case of Kimura’s disease involving parotid gland, lymph nodes, skin, and subcutaneous tissue diagnosed on frozen section. Indian J Pathol Microbiol 64(2):428–429

    PubMed  Google Scholar 

  53. Ho J, Walter S, Harvey RJ (2021) Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab. BMJ Case Rep 14(1):e232627

    Article  PubMed  PubMed Central  Google Scholar 

  54. Sousa CP, Fonseca E, Viamonte B, Lobo JC, Madureira A (2020) Kimura’s disease: a rare cause of facial mass in a caucasian male patient. BJR Case Rep 6(4):20200099

    PubMed  PubMed Central  Google Scholar 

  55. Wang X, Ma Y, Wang Z (2019) Kimura’s disease. J Craniofac Surg 30(5):e415–e418

    Article  PubMed  Google Scholar 

  56. Syed M, Bhattacharya D, Parida B, Sharma A (2017) Detailed imaging findings in a rare case of Kimura disease, with special mention on diffusion weighted imaging. Pol J Radiol 82:607–611

    Article  PubMed  PubMed Central  Google Scholar 

  57. Sharma R (2017) Superficial parotidectomy plane for debulking surgery in Kimura disease. J Craniofac Surg 28(3):e207–e208

    Article  PubMed  Google Scholar 

  58. Baba A, Ojiri H, Dogru M, Tanaka Y, Takahashi S, Mogami T, Kobashi Y, Yamazoe S, Nozawa Y, Ogino N, Yamauchi H, Aoyagi Y (2016) An unusual clinical presentation of Kimura disease manifesting with a typical cephalocervical lesion and an atypical subcutaneous hip mass lesion. Intern Med 55(8):1017–1020

    Article  CAS  PubMed  Google Scholar 

  59. Chaudhary R, Elhence P, Porwal P (2016) Kimura’s disease revisited: report of a case with a clinical and cytohistological correlation. BMJ Case Rep. https://doi.org/10.1136/bcr-2016-214410

    Article  PubMed  PubMed Central  Google Scholar 

  60. Luo G, Gu F, Liu T, Huang Y (2016) Kimura’s disease of the right cheek: a case report. Exp Ther Med 11(1):218–220

    Article  CAS  PubMed  Google Scholar 

  61. Sakitani E, Nonaka M, Shibata N, Furukawa T, Yoshihara T (2015) Increased expression of thymic stromal lymphopoietin and its receptor in Kimura’s disease. Orl J Otorhinolaryngol Relat Spec 77(1):44–54

    Article  CAS  PubMed  Google Scholar 

  62. Chopinaud M, Morice C, Comoz F, Petit A, Battistella M, Stefan A, Verneuil L (2013) Un cas de maladie de Kimura dans une forme atypique [An atypical form of Kimura’s disease. Ann Dermatol Venereol 140(11):699–703

    Article  CAS  PubMed  Google Scholar 

  63. Da-Long S, Wei R, Bing G, Yun-Yan Z, Xiang-Zhen L, Xin L (2014) Tacrolimus on Kimura’s disease: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 117(2):e74–e78

    Article  PubMed  Google Scholar 

  64. Dik VK, van de Wiel BA, Vasmel WL (2010) Kimura’s disease of the parotid glands and multiple cervical lymph nodes. Neth J Med 68(4):175–177

    CAS  PubMed  Google Scholar 

  65. Milentijeví MJ, Basić M, Petrović A (2009) Kimura’s disease in a young Balkan male. Vojnosanit Pregl 66(1):66–68

    Article  PubMed  Google Scholar 

  66. Bağdatli D, Kara IG, Bir F (2008) Kimura disease in the parotid gland region. J Otolaryngol Head Neck Surg 37(3):E76–E79

    PubMed  Google Scholar 

  67. Dave B, Desai S, Ramadwar M (2007) Kimura disease with proliferative squamous metaplasia: an unusual finding and a potential diagnostic pitfall. Indian J Pathol Microbiol 50(4):771–773

    PubMed  Google Scholar 

  68. Meningaud JP, Pitak-Arnnop P, Fouret P, Bertrand JC (2007) Kimura’s disease of the parotid region: report of 2 cases and review of the literature. J Oral Maxillofac Surg 65(1):134–140

    Article  PubMed  Google Scholar 

  69. Hood GKC, Pang KP, Teng PW (2006) Kimura’s disease of the parapharyngeal space. Ear Nose Throat J 85(2):106–108

    Article  Google Scholar 

  70. Kurukahvecioğlu S, Yardimci S, Kurukahvecioğlu O, Yilmaz E (2003) Kimura’s disease in the parotid and submandibular regions: two case reports. Kulak Burun Bogaz Ihtis Derg 11(5):157–160

    PubMed  Google Scholar 

  71. von Sivers K, Kettis AA, Svedhem V, Sandstedt B, Garmelius B, Jacobsson H (2000) Uptake of 111In-pentetreotide and 99mTc-labeled autologous granulocytes in Kimura’s disease. Eur Radiol 10(6):1026–1028

    Article  Google Scholar 

  72. Karavattathayyil SJ, Krause JR (2000) Kimura’s disease: a case report. Ear Nose Throat J 79(3):195–196 (Erratum in: Ear Nose Throat J 2000 Apr;79(4):248)

    Article  CAS  PubMed  Google Scholar 

  73. Boccato P, Mannarà GM, Rinaldo A, La Rosa F, Ferlito A (1999) Kimura’s disease of the intraparotid lymph nodes: fine needle aspiration biopsy findings. Orl J Otorhinolaryngol Relat Spec 61(4):227–231

    Article  CAS  PubMed  Google Scholar 

  74. Wade B, Arteaga C, Kraemer P, Duboscq JC, Molinier S, Perret JL (1998) Le granulome eosinophile des tissues mous ou maladie de Kimura: a propos d’un cas [Soft tissue eosinophilic granuloma or Kimura’s disease: a case report. Med Trop 58(4 Suppl):482–484 (French)

    CAS  Google Scholar 

  75. Woldag K, Bootz F, Weidenbach H, Parotistumor FT (1997) Morbus Kimura of the Glandula Parotis [Parotid tumor. Kimura disease of the parotid gland]. HNO 45(6):466–467 (German)

    CAS  PubMed  Google Scholar 

  76. Goldenberg D, Gatot A, Barki Y, Leiberman A, Fliss DM (1997) Computerized tomographic and ultrasonographic features of Kimura’s disease. J Laryngol Otol 111(4):389–391

    Article  CAS  PubMed  Google Scholar 

  77. Lim WE, Tan NG, Tan KP (1997) Radiological features in a patient with Kimura’s disease. Singap Med J 38(3):125–128

    Article  CAS  Google Scholar 

  78. Ussmüller J, Donath K, Shimizu M, Bergmann I (1997) Zur Differentialdiagnose tumoröser Raumforderungen der Gl. parotis: Angiolymphoide Hyperplasie mit Eosinophilie und Kimura’s disease [Differential diagnosis of tumorous space-occupying lesions of the parotid gland: angiolymphoid hyperplasia with eosinophilia and Kimura disease]. Laryngorhinootologie 76(2):110–115 (German)

    Article  PubMed  Google Scholar 

  79. Jani A, Coulson M (1997) Kimura’s disease. A typical case of a rare disorder. West J Med 166(2):142–144

    CAS  PubMed  PubMed Central  Google Scholar 

  80. Takahashi S, Ueda J, Furukawa T, Tsuda M, Nishimura M, Orita H, Tsujimura T, Araki Y (1996) Kimura disease: CT and MR findings. AJNR Am J Neuroradiol 17(2):382–385

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Nagamachi S, Hoshi H, Ohnishi T, Jinnouchi S, Flores LG 2nd, Futami S, Watanabe K, Tsuboi Y, Miyanaga S, Morimitsu T (1996) Tl-201 SPECT in Kimura’s disease involving the parotid glands and cervical nodes. Clin Nucl Med 21(2):125–128

    Article  CAS  PubMed  Google Scholar 

  82. Ahuja AT, Loke TK, Mok CO, Chow LT, Metreweli C (1995) Ultrasound of Kimura’s disease. Clin Radiol 50(3):170–173

    Article  CAS  PubMed  Google Scholar 

  83. Nyrop M (1994) Kimura’s disease: case report and brief review of the literature. J Laryngol Otol 108(11):1005–1007

    Article  CAS  PubMed  Google Scholar 

  84. Som PM, Biller HF (1992) Kimura disease involving parotid gland and cervical nodes: CT and MR findings. J Comput Assist Tomogr 16(2):320–322

    Article  CAS  PubMed  Google Scholar 

  85. Baretton G, Uthgenannt D, Löhrs U (1991) Kimura-Erkrankung (eosinophiles lymphofolli-kuläres Granulom), assoziiert mit minimal proliferierender Glomerulonephritis und nephrotischem Syndrom [Kimura disease (eosinophilic lymphofollicular granuloma), associated with minimal proliferative glomerulo-nephritis and nephrotic syndrome]. Pathologe 12(4):221–225 (German)

    CAS  PubMed  Google Scholar 

  86. Kuo TT, Shih LY, Chan HL (1988) Kimura’s disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol 12(11):843–854

    Article  CAS  PubMed  Google Scholar 

  87. Rudwaleit M, Andermann B, Alten R, Sörensen H, Listing J, Zink A, Sieper J, Braun J (2002) Atopic disorders in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 61(11):968–974

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Vitte J, Vibhushan S, Bratti M, Montero-Hernandez JE, Blank U (2022) Allergy, anaphylaxis, and nonallergic hypersensitivity: IgE, mast cells, and beyond. Med Princ Pract 31(6):501–515

    Article  PubMed  PubMed Central  Google Scholar 

  89. Ishizaka K, Ishizaka T (1967) Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol 99(6):1187–1198

    Article  CAS  PubMed  Google Scholar 

  90. Smith SA, Chruszcz M, Chapman MD, Pomés A (2023) Human monoclonal IgE antibodies—a major milestone in allergy. Curr Allergy Asthma Rep 23(1):53–65

    Article  CAS  PubMed  Google Scholar 

  91. Hrubisko M, Danis R, Huorka M, Wawruch M (2021) Histamine intolerance—the more we know the less we know. A review. Nutrients 13(7):2228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Abuel-Haija M, Hurford MT (2007) Kimura disease. Arch Pathol Lab Med 131(4):650–651

    Article  PubMed  Google Scholar 

  93. Ye P, Ma DQ, Yu GY, Gao Y, Peng X (2017) Comparison of the efficacy of different treatment modalities for Kimura’s disease. Int J Oral Maxillofac Surg 46(3):350–354

    Article  CAS  PubMed  Google Scholar 

  94. Lee CC, Feng IJ, Chen YT, Weng SF, Chan LP, Lai CS, Lin SD, Kuo YR (2022) Treatment algorithm for Kimura’s disease: a systematic review and meta-analysis of treatment modalities and prognostic predictors. Int J Surg 100:106591

    Article  PubMed  Google Scholar 

  95. Kottler D, Barète S, Quéreux G, Ingen-Housz-Oro S, Fraitag S, Ortonne N, Deschamps L, Rybojad M, Flageul B, Crickx B, Janin A, Bagot M, Battistella M (2015) Retrospective multicentric study of 25 Kimura disease patients: emphasis on therapeutics and shared features with cutaneous IgG4-related disease. Dermatology 231(4):367–377

    Article  CAS  PubMed  Google Scholar 

  96. Nonaka M, Sakitani E, Yoshihara T (2014) Anti-IgE therapy to Kimura’s disease: a pilot study. Auris Nasus Larynx 41(4):384–388

    Article  PubMed  Google Scholar 

  97. Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara T (2017) Basophils are increased and express increased levels of interleukin‑4 in the parotid lesions of Kimura disease. Asia Pac Allergy 7(4):221–226

    Article  PubMed  PubMed Central  Google Scholar 

  98. Yang B, Yu H, Jia M, Yao W, Diao R, Li B, Wang Y, Li T, Ge L, Wang H (2022) Successful treatment of dupilumab in Kimura disease independent of IgE: A case report with literature review. Front Immunol 13:1084879

    Article  PubMed  PubMed Central  Google Scholar 

  99. Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suárez-Fariñas M, Hager MD, Stahl N, Yancopoulos GD, Radin AR (2014) Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med 371(2):130–139

    Article  PubMed  Google Scholar 

  100. Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, Schwartz LB, Rosenwasser LJ, Ring J, Griffin EF, Haig AE, Frewer PI, Parkin JM, Gleich GJ, Mepolizumab HES Study Group (2008) Treatment of patients with the hyper-eosinophilic syndrome with mepolizumab. N Engl J Med 358(12):1215–1228 (Erratum in: N Engl J Med. 2008 Jun 5;358(23): 2530)

    Article  CAS  PubMed  Google Scholar 

  101. Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN, Mason J, Sattar N, McMurray JJV, McInnes IB, Khunti K, Cambridge G (2023) Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. Lancet 401(10391):1878–1890

    Article  PubMed  Google Scholar 

  102. Adler BL, Krausz AE, Minuti A, Silverberg JI, Lev-Tov H (2016) Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): a systematic review. J Am Acad Dermatol 74(3):506–12.e11

    Article  PubMed  Google Scholar 

  103. Wallace ZS, Miles G, Smolkina E, Petruski-Ivleva N, Madziva D, Cook C, Fu X, Zhang Y, Stone JH, Choi HK (2023) Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults. Ann Rheum Dis. https://doi.org/10.1136/ard-2023-223950

    Article  PubMed  Google Scholar 

  104. Albrecht K, Binder S, Minden K, Poddubnyy D, Regierer AC, Strangfeld A, Callhoff J (2023) Systematic review to estimate the prevalence of inflammatory rheumatic diseases in Germany. Z Rheumatol. https://doi.org/10.1007/s00393-022-01302-5

    Article  PubMed  PubMed Central  Google Scholar 

  105. Kakehi E, Kotani K, Otsuka Y, Fukuyasu Y, Hashimoto Y, Sakurai S, Hirotani A, Simizu K, Fujita R, Shoji K, Adachi S, Matsumura M (2020) Kimura’s disease: effects of age on clinical presentation. QJM 113(5):336–345

    Article  CAS  PubMed  Google Scholar 

  106. Glibbery N et al (2018) Kimura’s disease of the parotid gland with cutaneous features in a Caucasian female patient. J Surg Case Rep 2018(4):rjy67. https://doi.org/10.1093/jscr/rjy067

    Article  PubMed  PubMed Central  Google Scholar 

  107. Djawari DJ, Rumpelt HJ (2001) Angiolymphoid hyperplasia with eosinophilia. Akt Dermatol 27(12):414–416. https://doi.org/10.1055/s-2001-19627

    Article  Google Scholar 

  108. Kroese FGM, Haacke EA, Bombardieri M (2018) The role of salivary gland histopathology in primary Sjögren’s syndrome: promises and pitfalls. Clin Exp Rheumatol 36(Suppl 112(3)):222–233

    PubMed  Google Scholar 

  109. Deshpande V et al (2012) Consensus statement on the pathology of IgG4-related disease. Mod Pathol 25:1181–1192. https://doi.org/10.1038/modpathol.2012.72

    Article  PubMed  Google Scholar 

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  1. Rheumapraxis Berlin, Schlossstr. 110, 12163, Berlin, Deutschland

    Jürgen Braun & Kirsten Karberg

  2. Ruhr Universität Bochum, Bochum, Deutschland

    Jürgen Braun

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Braun, J., Karberg, K. Speicheldrüsenschwellung und Sicca-Symptomatik bei Morbus Kimura, einer seltenen rheumatologischen Differenzialdiagnose mit wegweisend hohem IgE-Serumspiegel – eine aktuelle Übersicht nach Literatursuche. Z Rheumatol (2023). https://doi.org/10.1007/s00393-023-01411-9

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